Cancer Dissemination During Laparoscopic Surgery: Tubes, Gas, and Cells

Targarona, E. M.; Martínez, J.; Nadal, Alfons; Balagué, Carmen; Cardesa, Antonio; Pascual, Salvador; Trías, Manuel

doi:10.1016/s0022-5347(05)68661-2

Cited by 5 publications

(7 citation statements)

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“…13,14 The pneumoperitoneum in itself seems to affect local immune reactions, facilitating the growth and hematogenous spread of tumor cells. 15,16 On the other hand, animal studies 17 have shown laparotomy to induce more tumor growth than laparoscopy, probably owing to a better preservation of immune function in case of laparoscopy.…”

mentioning

confidence: 99%

Open Versus Laparoscopic Pelvic Lymph Node Dissection in Early Stage Cervical Cancer: No Difference in Surgical or Disease Outcome

Lande

Mensdorff‐Pouilly

Lettinga

et al. 2012

Int J Gynecol Cancer

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mentioning

confidence: 99%

Open Versus Laparoscopic Pelvic Lymph Node Dissection in Early Stage Cervical Cancer: No Difference in Surgical or Disease Outcome

Lande

Mensdorff‐Pouilly

Lettinga

et al. 2012

Int J Gynecol Cancer

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“…Tierexperimentell wurden von mehreren Arbeitsgruppen [3,14,20,21,22,23] unabhängig voneinander verschiedene Modelle etabliert, bei denen es allerdings zu einem extrem unterschiedlichen Verhalten der Portmetastasierungstendenz kam.Von einigen Autoren [14,16] wurde ein sehr ausgeprägtes Portmetasierungsverhalten, insbesondere unter CO 2 -Anwendung berichtet, während von anderen Arbeitsgruppen [23,24] das Phänomen der Portmetastasierung als irrelevant beschrieben wurde.…”

Section: Gynäkologische Und Urologische Datenunclassified

Portmetastasen: Fakt oder Fiktion?

Fornara

2002

Urologe [A]

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In the early 1990s, the first reports appeared indicating a disturbingly high incidence (20%) of port site metastases following laparoscopic procedures for visceral and gynecological malignancies. At the same time, animal experiments were performed to investigate the phenomenon of port site metastases. The results were independently and repeatedly verified by different groups. In view of these distressing facts, a controversial, at times emotional discussion arose that evolved at least in part without strict regard to the available data. In the recent past, reports on increased incidence of port site metastases after laparoscopic interventions have completely vanished from the literature. Figures on incidence reported by various authors range between 0.5% and 1.3% and thus are comparable to the rate for surgical wound metastases (0.8-1.6%) as known from open conventional methods. Prospective studies have even shown that the survival rate in comparison to conventional techniques is 20% better, at least for laparoscopically treated stage I-III colorectal carcinomas. At present the discussion on the phenomenon of port site metastases can be considered closed. Port site metastases are thus no longer a fact, but also not fiction, since this phenomenon does occur in a small percentage of patients after laparoscopy just as after open surgery.

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“…Mathew et al and Jones et al found that the use of CO 2 favours scar tumour implantation 4,10 . In a general way, cellular implantations are favoured by postoperative immunosuppression, the mobilization and exfoliation of tumour cells, cellular adhesion, notably at the level of wounds, and the nature of the tumour (ability to spread naturally) 11,12 . Several mechanisms could be postulated for the formation of scar implants during laparoscopy: direct or indirect contamination, 13,14 aerosolization of tumour cells because of leaks around the trocar 15 or exsufflation after retraction of the trocar.…”

Section: Introductionmentioning

confidence: 99%

No difference found in survival using carbon dioxide laparoscopy, helium laparoscopy, or laparotomy in an adenocarcinoma nude mouse model

Narducci¹,

Lanvin²,

Occelli³

et al. 2000

Gynaecol Endoscopy

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Objective To evaluate the impact of surgical approach on tumour growth and survival of xenografted nude mice. Materials and methods 237 mice which had received 106 SKOV‐3 (human ovarian adenocarcinoma) cells subcutaneously and intraperitoneally, were anaesthetized for 60 min. The animals were randomly allocated to one of four groups: control group (n = 57), laparotomy (n = 61), CO2 laparoscopy (n = 62), or He laparoscopy (n = 57). Results Scar tumour grafts were found in 83.6% in the laparotomy group and in 64.5% in the group which underwent CO2 laparoscopy (P = 0.02). No significant differences were observed between any of the groups in relation to subcutaneous tumour volume at day 30 (P = 0.95), the intraperitoneal tumour volume (P = 0.70), the frequency of peritoneal carcinomatosis (P = 0.55), mesocolic and submesocolic tumour location (P = 0.52) or diaphragmatic metastases (P = 0.97). Moreover, no effect was found on the period of survival of the animals (P = 0.83). The average duration of survival was 63.4 ± 18.2 days (control), 64.2 ± 13.2 (laparotomy), 65.2 ± 16.9 (CO2) and 64.9 ± 16.5 (helium). Conclusion In the model used, CO2 laparoscopy is not associated with increased risk of tumour dissemination, scar implantation or death.

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Cancer Dissemination During Laparoscopic Surgery: Tubes, Gas, and Cells

Cited by 5 publications

References 0 publications

Open Versus Laparoscopic Pelvic Lymph Node Dissection in Early Stage Cervical Cancer: No Difference in Surgical or Disease Outcome

Open Versus Laparoscopic Pelvic Lymph Node Dissection in Early Stage Cervical Cancer: No Difference in Surgical or Disease Outcome

Portmetastasen: Fakt oder Fiktion?

No difference found in survival using carbon dioxide laparoscopy, helium laparoscopy, or laparotomy in an adenocarcinoma nude mouse model

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