Cancer disparities in Southeast Asia: intersectionality and a call to action

Feliciano, Erin Jay G.; Ho, Frances Dominique V.; Yee, Kaisin; Paguio, Joseph A.; Eala, Michelle Ann B.; Robredo, Janine Patricia G.; Ng, Kenrick; Lim, Jasmine; Pyone, Khin Thuzar; Peralta, Catherine A.; Flores, Jerickson Abbie; Yao, J. Seth; Santos, Patricia Mae G.; Ang, Christian Daniel U.; Lasco, Gideon; Chan, Jeffrey Shi Kai; Tse, Gary; Tangco, Enrico D.; Kingham, T. Peter; Chitapanarux, Imjai; Bhoo-Pathy, Nirmala; Legaspi, Gerardo D.; Dee, Edward Christopher

doi:10.1016/j.lanwpc.2023.100971

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…Another factor that adds complexity in analysing Asian healthcare standards is that breast cancer data is not available for many healthcare systems in poorer Asian countries. However, previous large cohort studies have reported worse breast cancer outcomes amongst less affluent Asian ethnicities, especially amongst minority groups, suggesting significant discrepancies in treatments provided between regions exist [64].…”

Section: Asiamentioning

confidence: 94%

Screening and Testing for Homologous Recombination Repair Deficiency (HRD) in Breast Cancer: an Overview of the Current Global Landscape

Daly,

Naidoo,

Alabdulrahman

et al. 2024

Curr Oncol Rep

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Purpose of Review Homologous recombination repair deficiency (HRD) increases breast cancer susceptibility and influences both prophylactic and active management of breast cancer. This review evaluates HRD testing and the therapeutic implications of HRD in a global context. Recent Findings Ongoing research efforts have highlighted the importance of HRD beyond BRCA1/2 as a potential therapeutic target in breast cancer. However, despite the improved affordability of next-generation sequencing (NGS) and the discovery of PARP inhibitors, economic and geographical barriers in access to HRD testing and breast cancer screening do not allow all patients to benefit from the personalized treatment approach they provide. Summary Advancements in HRD testing modalities and targeted therapeutics enable tailored breast cancer management. However, inequalities in access to testing and optimized treatments are contributing to widening health disparities globally.

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Section: Asiamentioning

confidence: 94%

Screening and Testing for Homologous Recombination Repair Deficiency (HRD) in Breast Cancer: an Overview of the Current Global Landscape

Daly,

Naidoo,

Alabdulrahman

et al. 2024

Curr Oncol Rep

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“…Whether the observed SDOHmortality associations differ by race/ethnicity also warrants further research. 1,10 Notwithstanding this study's nationally representative nature, it was limited by NHIS' self-reported nature, and the lack of individual data adjudication potentially predisposing to mortality data miscoding. Low event rates precluded subgroup/exploratory analyses, and the observational nature precluded causal inferences.…”

Section: Introductionmentioning

confidence: 99%

“…Whether the observed SDOH-mortality associations differ by race/ethnicity also warrants further research. 1,10…”

mentioning

confidence: 99%

Association between social determinants of health and cardiovascular and cancer mortality in cancer survivors: a nationally representative cohort study

Chan,

Satti,

Ching

et al. 2024

Preprint

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Although it is known that social deprivation is associated with higher risks of cardiovascular and cancer mortality in the general population, these associations may not be directly applicable to cancer survivors. Using data from the National Health Interview Survey (NHIS) 2013-2017 with follow-up till the end of 2019, we examined the associations between social determinants of health (SDOH) and the risk of all-cause, cardiovascular, and cancer mortality in cancer survivors, with separate modelling in individuals without cancer for comparison. Two Cox regression models were fitted for each outcome, the first being adjusted for demographics and the second being additionally adjusted for comorbidities and risk factors. Altogether, 37,882 individuals were analysed (representing a weighted population of 57,696,771), including 4179 cancer survivors and 33,703 individuals without cancer. Amongst cancer survivors, worse SDOH was associated with higher all-cause, cardiovascular, and cancer mortality when adjusted for demographics, which were attenuated but remained significant when further adjusted for comorbidities and risk factors. Amongst individuals without cancer, worse SDOH was associated with higher all-cause and cardiovascular mortality only when adjusted for demographics, but not when further adjusted for comorbidities and risk factors. These suggested that in cancer survivors, associations between SDOH and cardiovascular/cancer mortality may be driven by factors beyond comorbidities and risk factors, contrasting individuals without cancer in whom similar associations were probably driven mostly by comorbidities and risk factors.

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Processes of Creating a National Cancer Registry System in the Philippines

Tan,

Feliciano,

Habaluyas

et al. 2024

E J Info Sys Dev Countries

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As a new entrant in the Philippine Cancer Health Information Network, the Philippine Cancer Center (PCC) was pushed to establish the National Cancer Registry as mandated by the National Integrated Cancer Control Act (NICCA). The researchers used a rapid review and rapid realist review approaches which made use of evidence from literature and data from 43 key informant interviews and FGDs to create the National Cancer Registry Development Plan. The results were summarized using a cancer data process flow diagram, context‐view system architecture model, and logic models detailing the roadmap plans for the next 10 years. The study was able to show how the development of a national cancer registry plan that seeks to unite existing population‐based cancer registries (PBCRs) and hospital‐based cancer registries (HBCRs) is only possible through extensive collaboration and effective stakeholder engagement. Using an evidence‐based approach with expert knowledge and validation, the Philippine National Cancer Registry Development Plan was created, an example of an e‐health policy making process from which other developing countries can learn from.

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Cancer disparities in Southeast Asia: intersectionality and a call to action

Cited by 3 publications

References 29 publications

Screening and Testing for Homologous Recombination Repair Deficiency (HRD) in Breast Cancer: an Overview of the Current Global Landscape

Screening and Testing for Homologous Recombination Repair Deficiency (HRD) in Breast Cancer: an Overview of the Current Global Landscape

Association between social determinants of health and cardiovascular and cancer mortality in cancer survivors: a nationally representative cohort study

Processes of Creating a National Cancer Registry System in the Philippines

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