Cancer Diagnosis With Positron Computed Tomography and Carbon-11-Labelled L-Methionine

Kubota, Keiichi; Ito, M.; Abe, Yoshinao; Fujiwara, Takehiko; Hatazawa, Jun; Iwata, Ren; Ishiwata, Kiichiro; Fukuda, Hiroshi; Ito, Kengo; Yoshioka, Seiro; Matsuzawa, Taiju; Watanuki, S.; Ido, Tatsuo

doi:10.1016/s0140-6736(83)91235-7

Cited by 20 publications

(8 citation statements)

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“…Since almost all neoplastic cells show alterations in their methionine metabolism due to (1) their inability to synthesize it, (2) increased transport and (3) altered DNA methylation patterns, [ 11 C]methionine-PET could be useful in giving information on protein metabolism and possibly on tumour proliferation. Methionine has proved useful diagnostic agent in a number of malignancies, including lung cancer [16][17][18][19][20]. In addition, a relationship between methionine uptake and histological subtype has been demonstrated in primary lung cancer [21].…”

Section: Discussionmentioning

confidence: 99%

“…Due to a metabolic defect, almost all tumour cells share a 'methionine dependence' [15], supporting the use of radiolabelled methionine in PET imaging. Several studies demonstrated that methionine is able to detect various malignancies [16][17][18]. Specifically, Kubota et al [19], comparing the uptake of This study has been designed to compare the radiolabelled deoxyglucose and methionine uptake in non-smallcell lung cancer cell lines and to look for a correlation between these tracers and a standard indicator of proliferation, tritiated thymidine.…”

Section: Introductionmentioning

confidence: 99%

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Uptake of Tritiated Thymidine, Deoxyglucose and Methionine in Three Lung Cancer Cell Lines: Deoxyglucose Uptake Mirrors Tritiated Thymidine Uptake

et al. 2001

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[¹⁸F]-fluorodeoxyglucose and [¹¹C]-methionine are tracers which are widely used in oncological positron emission tomography. This study has been designed to assess the deoxyglucose and methionine uptake behaviour in three cell lines from different lung cancer histotypes. Tracer uptake was compared with proliferative activity as determined by growth curves and tritiated thymidine uptake. Deoxyglucose paralleled thymidine in all cell lines, peaking in the lag phase, decreasing throughout the exponential phase, and reaching its minimum in the plateau phase. The correlation was statistically verified and Spearman’s ρ ranged from 0.79 to 0.99. The absolute methionine uptake was always highest and always peaked on day 2, followed by a quite rapid decrease. However, besides the delay in maximum uptake, methionine incorporation was also related to proliferation, although the statistical correlations were weaker. These results show for the first time a clear correlation between deoxyglucose uptake and cell proliferation in a model comparing tracer uptake in different growth phases. Although delayed, methionine uptake was also related to cell growth and its greater intensity could be of interest for clinical use.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Uptake of Tritiated Thymidine, Deoxyglucose and Methionine in Three Lung Cancer Cell Lines: Deoxyglucose Uptake Mirrors Tritiated Thymidine Uptake

et al. 2001

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“…Soon, the first report by Fukuda and colleagues regarding the applicability of FDG PET for diagnosing metastatic liver cancer was published in 1982 [2]. Later, [ 11 C]methionine was proved to be useful for lung cancer detection in 1983 [3], while [ 18 F]fluorodeoxygalactose was demonstrated to be useful for cancer imaging in 1986 [4]. In the same year, FDG PET was reported to be useful for evaluating the efficacy of therapy against an experimental tumor [5].…”

Section: History Of Molecular Imaging In Oncologymentioning

confidence: 99%

Molecular Imaging at Tohoku University: From Cancer to Neuroreceptors

Tashiro¹,

Fukuda²,

Itoh³

et al. 2008

CMIR

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Tohoku University has nearly a 30-year-long history of basic and clinical research in molecular imaging using radiopharmaceuticals. This article briefly overviews the various achievements of Tohoku University in the fields of oncology and neuroscience. It is noteworthy that most of the early data regarding oncology diagnosis using positron emission tomography (PET) were produced at the Cyclotron and Radioisotope Center of the university. Also, the center has various academic contributions to the filed of neuroscience. One of its major contributions is molecular imaging of histamine H1 receptors, and recent achievements in this topic are summarized in this paper. The histaminergic neuronal system is associated with various functions such as wakefulness, the sleep-wake cycle, appetite control, learning, memory and emotion. Using [ 11 C]doxepin and PET, various studies have been conducted regarding physiological changes such as aging and pathological changes such as Alzheimer's disease, depression, and schizophrenia. In addition, histamine H1 receptor antagonists (antihistamines) are frequently used for the treatment of allergic disorders. These compounds can induce sedative side effects that can cause serious traffic accidents. Objective measurement of the sedative property of antihistamines was started in the early 1980s and was established at Tohoku University using H1 receptor occupancy as an index. In the future, PET will undoubtedly be used more frequently in drug development.

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“…The faster uptake of 1 8~~~ by lung tumors compared with that by normal tissue observed by PET could help in the disease assessment and therapeutic decisions (Nolop et al, 1987). The uptake of [ll~l-methionine into malignant tissue appears a promising technique for differentiating between malignant and nonmalignant solitary pulmonary nodules (Kubota et al, 1985(Kubota et al, ,1988Fujiwara et al, 1989). Waxman (1987) assessed recent developments and some likely future contributions of nuclear medicine to the diagnosis of pulmonary neoplasia.…”

Section: Some Opportunities For Improvement Of Diagnostic Radioaerosolsmentioning

confidence: 99%

Diagnostic Aerosols: Current Status and Future Prospects

Gonda

1993

Aerosol Science and Technology

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The inhalation of diagnostic aerosols directly into the respiratory tract (RT) can mimic the entry of air, inhaled allergens, and toxins. Such inhalation has also the advantage for diagnosis of diseases of the RT in that the active ingredient has, at least initially, a high ratio of local/systemic concentration. Nonradioactive aerosols have been used in the bronchial reactivity testing and as contrast media in bronchography. More recent developments include the assessment of airway dimensions and presence of airway diseases by means of the aerosol bolus technique. Radiolabeled aerosols have been used for anatomical (static) imaging of RT and in the kinetic mode to follow the clearance processes. Gamma scintigraphy has been used extensively in the differential diagnosis of pulmonary embolism and ventilation defects. Detection and localization of airway obstruction are also possible using radioaerosols. Transport processes in the RT can be followed by delivering radiolabeled soluble probes by inhalation to study pulmonary and mucosal permeability, or by employing insoluble carriers to investigate mucociliary clearance. The three-dimensional functional heterogeneily of RT makes the use of three---dimensional imaging desirable in order to improve the anatomical resolution and the signal/noise ratio. Regional, rather than whole lung, measurements are preferable for similar reasons. It is envisaged that a wider availability of multiple-detector single photon emission computerized tomography and positron emission tomography cameras will enhance the spatial and temporal resolution of these diagnostic modalities. The specificity of the tests used in anatomical (static) imaging may be improved using immunoscintigraphic methods. The differential diagnosis based on measurement -of permeability may be advanced in the future by selection of more appropriate carriers of the radiolabels. It should be remembered that these advanced methods will not yield reproducible results without paying attention to the fundamental properties of aerosols, in particular, their instability to evaporation /condensation and deposition before entry to the patient's RT. Design of appropriate aerosol technology for use in diagnostic procedures poses an interesting challenge to aerosol scientists.

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Cancer Diagnosis With Positron Computed Tomography and Carbon-11-Labelled L-Methionine

Cited by 20 publications

References 5 publications

Uptake of Tritiated Thymidine, Deoxyglucose and Methionine in Three Lung Cancer Cell Lines: Deoxyglucose Uptake Mirrors Tritiated Thymidine Uptake

Uptake of Tritiated Thymidine, Deoxyglucose and Methionine in Three Lung Cancer Cell Lines: Deoxyglucose Uptake Mirrors Tritiated Thymidine Uptake

Molecular Imaging at Tohoku University: From Cancer to Neuroreceptors

Diagnostic Aerosols: Current Status and Future Prospects

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