Cancer diagnosis and suicide outcomes: Umbrella review and methodological considerations

Calati, Raffaella; Filipponi, Chiara; Mansi, William; Casu, Diego; Peviani, Giulia; Gentile, Guendalina; Tambuzzi, Stefano; Zoja, Riccardo; Fornaro, Michele; López-Castromán, Jorge; Madeddu, Fabio

doi:10.1016/j.jad.2021.08.131

Cited by 18 publications

(14 citation statements)

References 29 publications

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“…Decades between 25 and 41 years old were the least represented. These findings are consistent with the data reported in a recent literature review [ 45 ]. In our cases, we have not recorded suicides of pediatric cancer patients, although this phenomenon is well documented in the literature even in cancers with long-term survival [ 46 ].…”

Section: Discussionsupporting

confidence: 93%

A Descriptive Cohort of Suicidal Cancer Patients: Analysis of the Autopsy Case Series from 1993 to 2019 in Milan (Italy)

Gentile

Tambuzzi

Calati

et al. 2022

IJERPH

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Suicide in cancer patients has always been a subject of clinical studies, but the contribution of forensic pathology to this phenomenon is poorly reported. With the aim of at least partially filling this gap in information, at the Institute of Forensic Medicine of Milan, Italy, we assessed all suicides that occurred in cancer patients. A descriptive and retrospective analysis was carried out by examining the database of the Institute and autopsy reports. We included 288 suicide cases with proven cancer diseases. For each suicide, sex, age, country of origin, body area affected by cancer, further pathological history, medications, previous suicide attempts and suicidal communications, as well as the place where the suicide occurred, were assessed. Furthermore, from a forensic point of view, we considered the chosen suicide method and any involved means. The majority of cases were male older adults affected by lung, colon and prostate cancer. Violent suicide methods were prevalent, and the most represented suicide method was falling from height regardless of the body area affected by cancer. Such data may be of clinical use for clinicians engaged in the front lines in order to address suicide risk prevention strategies among cancer patients.

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Section: Discussionsupporting

confidence: 93%

A Descriptive Cohort of Suicidal Cancer Patients: Analysis of the Autopsy Case Series from 1993 to 2019 in Milan (Italy)

Gentile

Tambuzzi

Calati

et al. 2022

IJERPH

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“…Suicidal thoughts and suicide determined by cancer is an important clinical area in psychosocial oncology, 29 since a 2-2.5 higher rate of suicide has been found among the oncology population in comparison with the general population. 30,31 Several factors have been indicated as a risk for the increase of suicide such as; depression, male gender, loneliness and social isolation, advanced stage of cancer, first year after diagnosis and type of cancer (e.g., pancreas, head and neck cancer). 32 In this issue, an Egyptian study of 59,580 patients with gastric cancer confirmed a higher suicide mortality risk in divorced patients, patients not recommended for surgery because of an advanced stage of illness, and those who were males.…”

Section: The Problem Of Suicidal Thoughts and Suicidementioning

confidence: 99%

“…Suicidal thoughts and suicide determined by cancer is an important clinical area in psychosocial oncology, 29 since a 2–2.5 higher rate of suicide has been found among the oncology population in comparison with the general population 30,31 . Several factors have been indicated as a risk for the increase of suicide such as; depression, male gender, loneliness and social isolation, advanced stage of cancer, first year after diagnosis and type of cancer (e.g., pancreas, head and neck cancer) 32 .…”

Section: Overview Of the Special Issue Contentmentioning

confidence: 99%

Disparities and inequalities in cancer care and outcomes in patients with severe mental illness: Call to action

Grassi

Riba

2021

Psycho-Oncology

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Objectives: People with severe mental illness (SMI) are at extreme risk of being stigmatized and to receive poor quality physical care. It has been demonstrated that they have higher morbidity and poorer prognosis of several medical diseases than the general population, with an at least 10-20-year reduction in life expectancy. Methods: A special issue of Psycho-Oncology focusing on cancer care among patients affected by SMI was called by the Editorial Board of the journal, with the aim to explore cancer health disparities and inequalities among people with SMI, mortality from cancer, problems of communication between multidisciplinary oncology and psychiatric teams and need for more structured intervention (i.e., screening, prevention, treatment). Results: Authors from eight countries contributed. The problem of stigma and barriers to cancer care provision for patients with SMI were studied (e.g., the complex nature of SMI and healthcare providers' misunderstanding of SMI). Key barriers were related to both patients, clinicians and institutional problems, such as fragmentation of care. A higher mortality from cancer and poor knowledge about cancer risk-factors was shown in patients with SMI. Models of intervention were also proposed. Conclusions: Several conclusions have been recommended by the authors, such as the need for guidelines and clinical procedures specific for cancer care in mental health settings; large-scale studies to address the disparities of care in people with SMI; a larger vision of psychosocial oncology as the facilitator of the liaison between oncology and psychiatry.

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“…However, although AMSTAR-2 was considered most suitable among existing quality appraisal tools for our review [ 12 ], it has been previously found to set very high standards for its quality classifications [ 14 , 45 , 46 , 47 ]. A different quality appraisal tool may have yielded different results.…”

Section: Discussionmentioning

confidence: 99%

Health Effects of Electronic Cigarettes: An Umbrella Review and Methodological Considerations

Travis

Knoll

Cadham

et al. 2022

IJERPH

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E-cigarettes are often marketed as a safer alternative to combustible cigarettes. However, their health effects, especially those associated with long-term use, remain largely uncertain. We conducted an umbrella review of the cardiopulmonary and carcinogenic risks of e-cigarette use, distinguishing between short-term and long-term health effects. The search for systematic reviews was conducted across four electronic databases through 25 January 2022. Methodological quality was assessed using the AMSTAR-2 quality appraisal tool. Seventeen systematic reviews, including five meta-analyses, were included in our umbrella review. There was a clear underreporting of e-cigarette devices and e-liquid types, e-cigarette and cigarette exposure, and the health and smoking status of study participants. Overall, the findings suggest that short-term use of e-cigarettes may be associated with acute cardiopulmonary risks, although to a lesser extent than cigarette use. Long-term e-cigarette use may have pulmonary/respiratory benefits in those who switch from chronic cigarette smoking, particularly in individuals with asthma and chronic obstructive pulmonary disease (COPD). Evidence on intermediate and long-term carcinogenic effects is lacking. This umbrella review underscores the urgent need for systematic reviews with better adherence to established reporting guidelines, consistent definitions of duration of e-cigarette use, a focus on newer devices, and accounting for the impacts of former or current smoking.

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Cancer diagnosis and suicide outcomes: Umbrella review and methodological considerations

Cited by 18 publications

References 29 publications

A Descriptive Cohort of Suicidal Cancer Patients: Analysis of the Autopsy Case Series from 1993 to 2019 in Milan (Italy)

A Descriptive Cohort of Suicidal Cancer Patients: Analysis of the Autopsy Case Series from 1993 to 2019 in Milan (Italy)

Disparities and inequalities in cancer care and outcomes in patients with severe mental illness: Call to action

Health Effects of Electronic Cigarettes: An Umbrella Review and Methodological Considerations

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