Cancer Detecting Nanobot Using Positron Emission Tomography

Maheswari, R. Uma; Gnanamalar, S.Sheeba Rani; Gomathy, V.; Sharmila, P.

doi:10.2139/ssrn.3227782

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…The study on tumor-killing nanorobots keeps moving forward, accompanied by increasingly mature designs of nanorobots, leading to more effective and accurate earlystage clinical cancer diagnosis [185][186][187][188]. Maheswari et al [189] proposed another tumor-detecting nanorobot that could examine tumor cell growth in vivo using positron emission topography. In the meanwhile, an embedded system was embedded so that the nanorobot could be controlled through pre-programmed procedures on the Arduino software platform.…”

Section: Cancer Detection and Diagnosismentioning

confidence: 99%

Advances of medical nanorobots for future cancer treatments

et al. 2023

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Early detection and diagnosis of many cancers is very challenging. Late stage detection of a cancer always leads to high mortality rates. It is imperative to develop novel and more sensitive and effective diagnosis and therapeutic methods for cancer treatments. The development of new cancer treatments has become a crucial aspect of medical advancements. Nanobots, as one of the most promising applications of nanomedicines, are at the forefront of multidisciplinary research. With the progress of nanotechnology, nanobots enable the assembly and deployment of functional molecular/nanosized machines and are increasingly being utilized in cancer diagnosis and therapeutic treatment. In recent years, various practical applications of nanobots for cancer treatments have transitioned from theory to practice, from in vitro experiments to in vivo applications. In this paper, we review and analyze the recent advancements of nanobots in cancer treatments, with a particular emphasis on their key fundamental features and their applications in drug delivery, tumor sensing and diagnosis, targeted therapy, minimally invasive surgery, and other comprehensive treatments. At the same time, we discuss the challenges and the potential research opportunities for nanobots in revolutionizing cancer treatments. In the future, medical nanobots are expected to become more sophisticated and capable of performing multiple medical functions and tasks, ultimately becoming true nanosubmarines in the bloodstream. Graphical abstract

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Section: Cancer Detection and Diagnosismentioning

confidence: 99%

Advances of medical nanorobots for future cancer treatments

et al. 2023

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“…Through the use of drug-loaded micro/nanorobots, the some drugs can be effectively tracted and penetrated into the relevant tissues. Nanotechnology has opened up new possibilities for drug delivery ( Maheswari et al, 2018 ). In recent years, a large number of drug delivery systems have been developed, including liposomes composed of phospholipid bilayers ( Liu Y. et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The application of nanomedicine in clinical settings

Zhao

Cheng

Sun

et al. 2023

Front. Bioeng. Biotechnol.

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As nanotechnology develops in the fields of mechanical engineering, electrical engineering, information and communication, and medical care, it has shown great promises. In recent years, medical nanorobots have made significant progress in terms of the selection of materials, fabrication methods, driving force sources, and clinical applications, such as nanomedicine. It involves bypassing biological tissues and delivering drugs directly to lesions and target cells using nanorobots, thus increasing concentration. It has also proved useful for monitoring disease progression, complementary diagnosis, and minimally invasive surgery. Also, we examine the development of nanomedicine and its applications in medicine, focusing on the use of nanomedicine in the treatment of various major diseases, including how they are generalized and how they are modified. The purpose of this review is to provide a summary and discussion of current research for the future development in nanomedicine.

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“…Self-replicating nanoscale robots which can be used to repair, detect, deliver, or destroy bacteria, cancer cells, toxins, or the like would be a technological revolution in science and medicine. Although the popular depictions of mechanical nanobots are still in the distant future, scientists have proposed many versions of nanobots which can perform tasks such as deliver drugs, , detect cancer, and move within cells . The nanobots to date have typically been biological in nature, such as DNA structures, or inorganic such as nanocoils.…”

Section: Introductionmentioning

confidence: 99%

Engineering Biorthogonal Phage-Based Nanobots for Ultrasensitive, In Situ Bacteria Detection

Zurier

Duong

Goddard

et al. 2020

ACS Appl. Bio Mater.

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Advances in synthetic biology, nanotechnology, and genetic engineering are allowing parallel advances in areas such as drug delivery and rapid diagnostics. Although our current visions of nanobots may be far off, a generation of nanobots synthesized by engineering viruses is approaching. Such tools can be used to solve complex problems where current methods do not meet current demands. Assuring safe drinking water is crucial for minimizing the spread of waterborne illnesses. Although extremely low levels of fecal contamination in drinking water are sufficient to cause a public health risk, it remains challenging to rapidly detect Escherichia coli, the standard fecal indicator organism. Current methods sensitive enough to meet regulatory standards suffer from either prohibitively long incubation times or requirement of expensive, impractical equipment. Bacteriophages, tuned by billions of years of evolution to bind viable bacteria and readily engineered to produce custom proteins, are uniquely suited to bacterial detection. We have developed a biosensor platform based on magnetized phages encoding luminescent reporter enzymes. This system utilizes bio-orthogonally functionalized phages to enable site-specific conjugation to magnetic nanoparticles. The resulting phage-based nanobots, when combined with standard, portable field equipment, allow for detection of <10 cfu/100 mL of viable E. coli within 7 h, faster than any methods published to date.

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Cancer Detecting Nanobot Using Positron Emission Tomography

Cited by 4 publications

References 11 publications

Advances of medical nanorobots for future cancer treatments

Advances of medical nanorobots for future cancer treatments

The application of nanomedicine in clinical settings

Engineering Biorthogonal Phage-Based Nanobots for Ultrasensitive, In Situ Bacteria Detection

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