Cancer de vessie inhabituel : carcinome neuroendocrine à petites cellules pur de la vessie : à propos d’une observation et revue de la littérature

Primary Small-Cell Carcinoma of the Urinary Bladder: A Case Report and Literature Review

“…From the 286 reported cases of SCCB, the prevalence in male patients is estimated to be 84% [ 9 ]. Gross hematuria has been the most prominent symptom in around 90% of these patients; other symptoms, such as dysuria, pelvic pain, or even paraneoplastic syndromes, are less frequent [ 7 , 9 ].…”

“…Gross hematuria has been the most prominent symptom in around 90% of these patients; other symptoms, such as dysuria, pelvic pain, or even paraneoplastic syndromes, are less frequent [ 7 , 9 ]. It is estimated in some series that 94% of the cases had muscle invasion when the diagnosis was made [ 9 ], whereas metastatic diseases range, depending on the bibliography, from 67% [ 9 ] to 28-50% [ 7 ] during the disease course. The most common sites of metastatic disease are the lymph nodes, liver, bone, lung, and brain [ 7 , 9 ].…”

“…It is estimated in some series that 94% of the cases had muscle invasion when the diagnosis was made [ 9 ], whereas metastatic diseases range, depending on the bibliography, from 67% [ 9 ] to 28-50% [ 7 ] during the disease course. The most common sites of metastatic disease are the lymph nodes, liver, bone, lung, and brain [ 7 , 9 ].…”

“…First described by Koss in 1975 [6], the SCCB is described by the literature as a very uncommon BCa type, with an overall prevalence of 0.5-0.7% [1,2,7]. Despite its prevalence, it is reported to be an aggressive malignancy because of its high metastatic potential even when the bladder lesion appears as a "small lesion" [7][8][9]. Usually, the image found on the mucosa of the bladder is described as a necrotic ulcerated lesion of around 4-10 cm and has been difficult to differentiate from a transitional cell carcinoma (TCC) [7,9].…”

“…Despite its prevalence, it is reported to be an aggressive malignancy because of its high metastatic potential even when the bladder lesion appears as a "small lesion" [7][8][9]. Usually, the image found on the mucosa of the bladder is described as a necrotic ulcerated lesion of around 4-10 cm and has been difficult to differentiate from a transitional cell carcinoma (TCC) [7,9]. The most commonly described location in the bladder is the lateral wall (54%), followed by the posterior wall, trigone, dome, and anterior wall (20%, 10%, 8%, and 8%, respectively) [7,9].…”