Cáncer de próstata: la revolución de los genes de fusión

Fernández-Serra, Antonio; Rubio‐Briones, J.; García-Casado, Zaida; Solsona, E.; Löpez‐Guerrero, José Antonio

doi:10.4321/s0210-48062011000700008

Cited by 5 publications

(4 citation statements)

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“…The recent literature has described ERG positivity in~50% CaP [5,9,11]. Our patient group showed ERG positivity in 94% of CaP and in 77% of adjacent BPH/PIN.…”

Section: Discussionsupporting

confidence: 59%

“…In ERG-positive CaP, high expression of Wnt signal pathway effectors like FZD4 was also detected, which can contribute to cellular phenotype leading to the development of EMT (epithelial-mesenchymal transition) [7,8]. There is evidence supporting the hypothesis that the presence of the fusion gene, differentiates two molecular groups within prostate cancer with different behaviour, making the fusion gene a potential therapeutic target [9]. We deduce that parallel examination of TMPRSS2-ERG gene rearrangement and expression of AR, TOP2B and ERG in relation to clinicopathological status can contribute to better tumor specification.…”

Section: Relation Of Ets Transcription Factor Family Member Erg Andrmentioning

confidence: 99%

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Relation of ETS transcription factor family member ERG, androgen receptor and topoisomerase 2β expression to TMPRSS2-ERG fusion status in prostate cancer

Kolář¹,

Burdova²,

Jamaspishvili³

et al. 2014

neo

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Fusion of TMPRSS2 with ERG in prostate cells is determined by double-strand DNA breaks induced by androgen signaling and transcription stress. The enzyme topoisomerase 2β (TOP2B) mediating DNA processing, plays an important role in DNA cleavage. The aim of this study was to analyse expression of AR, TOP2B and ERG in relation to TMPRSS2-ERG gene rearrangement and relevant clinicopathological characteristics in prostate cancer (CaP). Immunohistochemical staining and FISH were used for investigation. ERG expression in prostate cell lesions positively correlated with levels of TMPRSS2-ERG fusion gene (p<0.0001). The most significant co-expression of ERG was found with AR in CaP (p=0.001). Significantly more frequent co-expression of ERG was also revealed with TOP2B (p=0.028). ERG protein expression did not correlate with CaP differentiation status as we found no significant differences in ERG expression for different Gleason categories. We demonstrated a statistically significant positive correlation between the percentage of cells with fusion gene TMPRSS2-ERG in CaP and metastatic potential of tumors (p=0.011). Besides these positive corelations of AR with ERG (p=0.001) and TOP2B with ERG (p=0.028), we also demonstrated a significant co-expression of AR with TOP2B (p=0.007) in CaP. There was a statistically significant increase in the TOP2B H-index in locally advanced CaP in comparison with localized tumors (p=0.046). ERG expression correlates with occurrence of TMPRSS2-ERG fusion and with AR-driven malignant transformation. The results indicate that detection of the TMPRSS2-ERG fusion gene and parallel immunohistochemical examination of AR, TOP2B and ERG has diagnostic significance and may be useful in assessing the biological character of the prostate cancer as well as selecting the best treatment.

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“…The recent literature has described ERG positivity in~50% CaP [5,9,11]. Our patient group showed ERG positivity in 94% of CaP and in 77% of adjacent BPH/PIN.…”

Section: Discussionsupporting

confidence: 59%

Section: Relation Of Ets Transcription Factor Family Member Erg Andrmentioning

confidence: 99%

Relation of ETS transcription factor family member ERG, androgen receptor and topoisomerase 2β expression to TMPRSS2-ERG fusion status in prostate cancer

Kolář¹,

Burdova²,

Jamaspishvili³

et al. 2014

neo

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“…Numerous authors have conducted studies over the past decades in an attempt to link the presence of the TMPRSS2 gene with the frequency of cancer and its prognosis. 16 Although there are studies that have found that the TM-PRSS2 gene does not represent a worse prognosis for prostate cancer, 17 an important fusion of that gene with the ERG gene was described, with an increasing relation to the diagnosis and aggressiveness of prostate cancer (present in 50% of high-risk prostate cancers). [18][19] We found a low frequency of the allelic variant associated with the TMPRSS2:ERG fusion gene in our cancer-free population from Southwestern Colombia.…”

Section: Discussionmentioning

confidence: 99%

Frequency of allelic variants of the TMPRSS2 gene in a prostate cancer-free Southwestern Colombian population

2018

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OBJECTIVE: To describe the frequency of the TMPRSS2 gene and its variants in a prostate cancer-free Southwestern Colombian population.MATERIALS AND METHODS: An observational study was conducted that included cancer-free persons, regardless of age, from Southwestern Colombia. Blood samples were drawn from the patients for DNA extraction. Blood drops were collected and dried on filters and immersed in phosphate buffer, utilizing the DNeasy kit. The preparation process was carried out using the TruSeq Exome Library Prep® kit and the resulting libraries were normalized with the TruSeq Rapid Exome® kit. The commercial kits were provided by Illumina®. We sequenced the full exome and identified the variants associated with the TMPRSS2 gene. Descriptive statistics were employed for the data analysis.RESULTS: The study population was made up of 162 persons from whom 7,315,466 sequence data were obtained. The TMPRSS2 gene was found in 414 data (4.3%). The most common SNP was rs140530035 (32.1%) and the most relevant SNP sequenced was rs12329760 (10.6%).CONCLUSION: TMPRSS2 was not frequent in the population studied. The most important polymorphism associated with the TMPRSS2 gene was rs12329760.KEYWORDS: Gene; Prostate cancer; TMPRSS2; Polymorphism.

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“…Para el ingreso del coronavirus a la célula diana, es necesaria la unión de la subunidad S1 de la glucoproteína de la superficie de la espiga viral (S) con los receptores de la ECA-2, al igual que lo hace el virus del SARS-CoV (39,40) . Por otro lado, la proteína S viral es acoplada a una proteína transmembrana con actividad serina proteasa tipo II codificada por el gen TMPRSS2, que está conformada por tres dominios: el dominio proteasa de S1, que permite la entrada y activación viral, el dominio LDLRA, que se une al calcio, y el dominio transmembrana (41) . La actividad del receptor de andrógenos (AR) es requerida para la transcripción del gen TMPRSS2 (42) .…”

Section: Covid-19 E Interacción Con Los Receptoresunclassified

COVID-19 y salud reproductiva

Gómez-Tabares

Barraza-Gerardino²

2020

Rev.ACE

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El comportamiento de las enfermedades microbianas, ya sea por virus, bacterias o protozoos, y su respuesta inflamatoria son diferentes entre hombres y mujeres. Esta diferencia se hace notoria en la pandemia derivada por la enfermedad por coronavirus (COVID-19). Desde el reporte del primer caso de neumonía en diciembre de 2019, en Wuhan, China, la COVID-19 se ha diseminado a 212 países y territorios y, a la fecha, se ha confirmado más de 3,5 millones de casos, con una mortalidad mundial del 7%, lo que la convierte en una emergencia sanitaria internacional (1). Hasta ahora, en Colombia, hay más de 7000 casos confirmados, con más de 300 defunciones, de los cuales, más del 60% pertenecen al sexo masculino. Hasta el momento, la literatura científica disponible relacionada con la COVID-19 solo abarca ciertos aspectos de la salud reproductiva, tanto femenina como masculina, mientras se continúa recopilando más información que nos permita conocer y realizar un análisis más detallado de su impacto real en humanos durante el proceso infeccioso y las secuelas derivadas de este. Está confirmado que las condiciones médicas relacionadas con el síndrome metabólico y los estados de insulinorresistencia en hombres y mujeres agravan la presentación clínica y el pronóstico (2). La presente revisión pretende ilustrar los mecanismos relacionados con la respuesta inmunitaria diversa frente a las infecciones virales según el sexo del individuo, su compromiso gonadal y los efectos relacionados con la salud reproductiva masculina y femenina, que incluye la maternofetal y la posible transmisión vertical.

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Cáncer de próstata: la revolución de los genes de fusión

Cited by 5 publications

References 0 publications

Relation of ETS transcription factor family member ERG, androgen receptor and topoisomerase 2β expression to TMPRSS2-ERG fusion status in prostate cancer

Relation of ETS transcription factor family member ERG, androgen receptor and topoisomerase 2β expression to TMPRSS2-ERG fusion status in prostate cancer

Frequency of allelic variants of the TMPRSS2 gene in a prostate cancer-free Southwestern Colombian population

COVID-19 y salud reproductiva

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