Cáncer de hipofaringe

Carrasco-Llatas, Marina; Mollá, C. López; García, Ramón Balaguer; Ramı́rez, Marı́a José; Doménech, Fernando; Ferriol, José Enrique Estellés; Martínez, Sergio Fernández; Galofre, José Dalmau

doi:10.1016/s0001-6519(09)70311-5

Cited by 4 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have reported that 60-80% of these patients had ipsilateral lymph node metastases and ≤40% of these patients have contralateral occult lymph node tumor deposits ( 1 - 3 ). Thus, the majority of patients with hypopharyngeal cancer have a poor prognosis and low survival rate ( 4 ). Therefore, identifying early stage indicators or biomarkers to improve patient survival is urgent.…”

Section: Introductionmentioning

confidence: 99%

CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer

Feng

Lin

et al. 2018

Int J Mol Med

View full text Add to dashboard Cite

Accumulating evidence has suggested that circular RNAs (circRNAs), a novel class of non-coding RNAs, have crucial roles in tumor progression. However, the significance of circRNAs in hypopharyngeal cancer (HCa) remains to be investigated. The present study has identified aberrantly expressed circRNAs by performing circRNA sequencing analyses of three pairs of tumor and adjacent normal samples from patients with HCa. The results demonstrated that 173 circRNAs were differentially expressed (DE), including 71 upregulated and 102 downregulated circRNAs (FDR<0.05 and fold changes of ≥2 or ≤0.5 by Mann-Whitney U test followed by Benjamini-Hochberg correction for multiple testing). Pathway analyses of the genes producing DE circRNAs revealed that many of them were involved in cancer-related pathways. To further illustrate the roles of circRNAs in HCa progression, a competing endogenous RNA (ceRNAs) network was constructed, consisting of circRNAs, miRNA, and miRNA targeted genes. The results demonstrated that multiple cancer-related pathways were affected by performing enrichment analyses of the targeted genes. Of note, a ceRNA subnetwork was isolated, consisting of two circRNAs (hsa_circ_0008287 and hsa_circ_0005027) and one miRNA (hsa-miR-548c-3p), which significantly affect both ErbB and Hippo signaling pathways. In conclusion, the present study identified a set of circRNAs that are potentially implicated in the tumorigenesis of HCa and may serve as potential biomarkers for the diagnosis of HCa.

show abstract

Section: Introductionmentioning

confidence: 99%

CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer

Feng

Lin

et al. 2018

Int J Mol Med

View full text Add to dashboard Cite

show abstract

“…Among all head and neck malignancies, hypopharyngeal cancer is associated with a poor prognosis due to its typical advanced stage at presentation and a high rate of metastasis to cervical lymph nodes 1 . Furthermore, the reconstruction process is exceptionally challenging due to difficulties in monitoring flap perfusion, the elevated risk of carotid vessel blowout, and the potential hazards of anastomosis strictures 2‐4 .…”

mentioning

confidence: 99%

Diet Outcome in Patients With Hypopharyngeal Defects Repaired With Different Reconstruction Flaps: A Comparative Study

Shih,

Chen,

Morrison

et al. 2024

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

ObjectivesTo assess potential risk factors influencing diet outcomes after reconstruction of subtotal hypopharyngeal defects using free patch‐ or tube‐shaped anterolateral thigh (ALT) fasciocutaneous flaps.Study DesignRetrospective cohort study.SettingFirst‐level referral hospital.MethodsBetween January 2011 and December 2020, we studied hypopharyngeal cancer patients who underwent the reconstruction of hypopharyngeal defects using free patch‐ or tube‐shaped ALT fasciocutaneous flaps. The choice between patch‐ or tube‐shaped ALT flaps depended on the defect's nature, favoring patch‐shaped for subtotal defects and tube‐shaped for circumferential defects. A restricted diet was characterized by a history of enterostomy or endoscopic esophageal dilation treatment postreconstruction. We analyzed patients with restricted diets at 1‐ and 3‐year follow‐up visits.ResultsNinety‐eight patients were enrolled; 39 patch‐shaped flaps, and 59 tube‐shaped flaps. No significances were noted in demographics, postoperative radiotherapy (RT) or chemotherapy, rates of free flap reoperation/salvage, or complications. However, a significant difference emerged in diet outcomes at the 1‐year follow‐up (P = .005). The rate of a restricted diet was 6.08 times higher in patients with tube‐shaped flaps compared to patch‐shaped flaps (95% confidence interval [CI]: 1.95‐18.94). Stratifying based on postoperative RT revealed a 5.47 times higher rate of a restricted diet in tube‐shaped flap recipients compared to patch‐shaped flap recipients (95% CI: 1.44‐20.48). No significances were observed in 5‐year survival rates.ConclusionConcerning postoperative RT, patch‐shaped flaps exhibited a lower incidence of a restricted diet compared to tube‐shaped flaps. Preservation of the posterior mucosa may play a crucial role in preventing RT‐induced esophageal stricture.

show abstract

Analysis of lymph nodes metastasis in hypopharyngeal squamous cell carcinoma based on contrast‐enhanced computed tomography imaging

Wang

Zhang

et al. 2021

Precision Radiation Oncology

View full text Add to dashboard Cite

Objective To investigate the frequency, distribution, and potential factors of lymphatic metastasis at each nodal level, and stratify the risk of lymph node metastasis in hypopharyngeal squamous cell carcinoma based on computed tomography. Methods Contrast‐enhanced computed tomography images of 176 patients with pathologically confirmed hypopharyngeal squamous cell carcinoma without any cancer‐related therapeutic history were analyzed retrospectively. The lymphatic metastasis ratio at each nodal level was determined. Potential factors that correlated with lymph node metastasis were identified using univariate and multivariate analyses. Results Metastatic lymph nodes were found in 145 (82.4%) of 176 patients. The lymphatic metastasis ratio was 0.6% (Ia), 4.0% (Ib), 67.6% (IIa), 43.8% (IIb), 45.5% (III), 13.1% (IV), 5.1% (Va), 1.7% (Vb), 1.7% (VIa), 12.5% (VIb), and 15.9% (VII) for each nodal level in the ipsilateral neck. In contrast, a lower lymphatic metastasis ratio was observed in the contralateral neck, with the highest measuring 18.2% at level IIa. Esophageal invasion was highly correlated with an increased risk of developing level VIb metastasis (P = 0.019). Furthermore, posterior pharyngeal wall invasion was highly correlated with an increased risk of level VII metastasis (P = 0.014). Conclusion In general, nodal levels IIa, III, and IIb were highly susceptible to metastasis in the ipsilateral neck. Nodal levels IV, VIb, and VII in the ipsilateral neck, and IIa in the contralateral neck showed a moderate risk of metastasis. Levels I and V were considered low risk. The anatomical characteristics and infiltration of tumors in different subsites should also be considered in the delineation of the clinical target volume.

show abstract

Cáncer de hipofaringe

Cited by 4 publications

References 21 publications

CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer

CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer

Diet Outcome in Patients With Hypopharyngeal Defects Repaired With Different Reconstruction Flaps: A Comparative Study

Analysis of lymph nodes metastasis in hypopharyngeal squamous cell carcinoma based on contrast‐enhanced computed tomography imaging

Contact Info

Product

Resources

About