Cancer Control and Complications of Salvage Local Therapy After Failure of Radiotherapy for Prostate Cancer: A Systematic Review

Parekh, Arti; Graham, Powell L.; Nguyen, Paul L.

doi:10.1016/j.semradonc.2013.01.006

Cited by 55 publications

(44 citation statements)

References 73 publications

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“…Increasing surgical experience has resulted in a decrease in the rate of surgical complications. In addition, biochemical outcomes reported in recent series suggest a superiority of SRP over other salvage treatment modalities, such as cryotherapy, high-intensity focused ultrasound, or brachytherapy [4]. …”

Section: Introductionmentioning

confidence: 99%

Salvage Radical Prostatectomy after External Beam Radiation Therapy: A Systematic Review of Current Approaches

Matei¹,

Ferro²,

Jereczek‐Fossa

et al. 2015

Urol Int

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Background: Radical external beam radiotherapy (EBRT) is a standard treatment for prostate cancer patients. Despite this, the rate of intraprostatic relapses after primary EBRT is still not negligible. There is no consensus on the most appropriate management of these patients after EBRT failure. For these patients, local salvage therapy such as radical prostatectomy, cryotherapy, and brachytherapy may be indicated. Objective: The objectives of this review were to analyze the eligibility criteria for careful selection of appropriate patients and to evaluate the oncological results and complications for each method. Methods: A review of the literature was performed to identify studies of local salvage therapy for patients who had failed primary EBRT for localized prostate cancer. Results: Most studies demonstrated that local salvage therapy after EBRT may provide long-term local control in appropriately selected patients, although toxicity is often significant. Conclusions: Our results suggest that for localized prostate cancer recurrence after EBRT, the selection of a local treatment modality should be made on a patient-by-patient basis. An improvement in selection criteria and an integrated definition of biochemical failure for all salvage methods are required to determine which provides the best oncological outcome and least comorbidity.

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Section: Introductionmentioning

confidence: 99%

Salvage Radical Prostatectomy after External Beam Radiation Therapy: A Systematic Review of Current Approaches

Matei¹,

Ferro²,

Jereczek‐Fossa

et al. 2015

Urol Int

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“…Patients with a PSADT <20 months require at least additional follow-up after salvage to assess disease progression or salvage should be offered earlier or perhaps not at all. Furthermore, the benefits of treatment regarding cancer control/survival need to be weighed against the exacerbated toxicity after whole-gland salvage I-125-brachytherapy, as was observed in this and previous series 5,6 .…”

Section: Discussionmentioning

confidence: 80%

“…Local salvage therapy is a potentially curative treatment for these prostate-confined recurrences. Whole-gland salvage can be performed using different techniques and is able to achieve long term biochemical control and survival and thereby postpone the use of androgen deprivation therapy (ADT) in carefully selected patient groups [5][6][7][8][9] . Risk factors for failure and mortality for salvage brachytherapy have not been comprehensively defined, because of small series with often limited events 5,9,10 .…”

Section: Introductionmentioning

confidence: 99%

Multivariable model development and internal validation for prostate cancer specific survival and overall survival after whole-gland salvage Iodine-125 prostate brachytherapy

Peters

Zyp

Moerland

et al. 2016

Radiotherapy and Oncology

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Background: Whole-gland salvage Iodine-125-brachytherapy is a potentially curative treatment strategy for localised prostate cancer (PCa) recurrences after radiotherapy. Prognostic factors influencing PCa-specific and overall survival (PCaSS & OS) are not known. The objective of this study was to develop a multivariable, internally validated prognostic model for survival after whole-gland salvage I-125-brachytherapy.

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“…In general, the frequency of serious adverse events following postradiotherapy salvage treatments is significantly greater than in the upfront setting. 5 No OAR dosimetric constraints have been established in the salvage reirradiation setting, and therefore, following the principle of "as low as reasonably achievable" with respect to OAR sparing is reasonable. This, in turn, would support using a focal approach, as long as it is oncologically isoeffective to a WG approach.…”

Section: Discussionmentioning

confidence: 99%

“…This may be particularly important in the context of salvage therapy for a local failure after definitive external beam radiotherapy (EBRT). In this setting, studies 2,4,5 suggest that the most common site of recurrence is at the site of the "index lesion" and whole-gland (WG) retreatment series report rates of incontinence and fistula ranging from 6.2% to 49.7% and from 1.6% to 3.6%, respectively.…”

Section: Introductionmentioning

confidence: 99%

Dosimetric benefits of hemigland stereotactic body radiotherapy for prostate cancer: implications for focal therapy

Kishan

Park

King

et al. 2015

BJR

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Objective: Compared with standard, whole-gland (WG) therapies for prostate cancer, focal approaches may provide equivalent oncologic outcomes with fewer adverse effects. The purpose of this study was to compare organ-at-risk (OAR) dosimetry between hemigland (HG) and WG stereotactic body radiotherapy (SBRT) plans. Methods: Volumetric-modulated arc radiotherapy-based SBRT plans were designed to treat the left HG, right HG and WG in eight patients, using five fractions of 8 Gy. OARs of interest included the contralateral HG, rectum, urinary bladder, urethra, penile bulb and contralateral neurovascular bundle. Results: Rectal V 80% (the percentage of a normal structure receiving a dose of 80%) and V 90% were significantly lower with HG plans than with WG plans (median values of 4.4 vs 2.5 cm 3 and 2.1 vs 1.1 cm 3 , respectively, p , 0.05 by Student's t-test). Bladder V 50% was also reduced significantly in HG plans (32.3 vs 17.4 cm 3 , p , 0.05), with a trend towards reduction of V 100% (3.4 vs 1.3 cm 3

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Cancer Control and Complications of Salvage Local Therapy After Failure of Radiotherapy for Prostate Cancer: A Systematic Review

Cited by 55 publications

References 73 publications

Salvage Radical Prostatectomy after External Beam Radiation Therapy: A Systematic Review of Current Approaches

Salvage Radical Prostatectomy after External Beam Radiation Therapy: A Systematic Review of Current Approaches

Multivariable model development and internal validation for prostate cancer specific survival and overall survival after whole-gland salvage Iodine-125 prostate brachytherapy

Dosimetric benefits of hemigland stereotactic body radiotherapy for prostate cancer: implications for focal therapy

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