Cancer clinical trials in Central and Eastern Europe: historical review

Jassem, Jacek; Schoket, Zsófia; Krzakowski, Maciej

doi:10.1016/s1040-8428(01)00170-6

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…However, the doctors who ask such questions to all patients are definitely less common (about one-third of them). As for mammography, the limitation in the group of patients who are asked about the examination may result from age limits for free breast screening under population prevention programs [26].…”

Section: Discussionmentioning

confidence: 99%

The role of occupational health services in cancer prevention – which factors determine the implementation of preventive measures?

Wiszniewska¹,

Marcinkiewicz²,

Lipińska‐Ojrzanowska³

et al. 2021

Int J Occup Med Environ Health

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Objectives: Epidemiological data on cancer diseases are alarming. The workplace has become an increasingly important site for disseminating health information and implementing health promotion activities. Occupational medicine physicians (OMPs) have the opportunity to carry out primary and secondary preventive activities focused on civilization diseases, especially cancer. The aim of this study was to evaluate the potential of OMPs in cancer prevention, including the analysis of factors determining the implementation of preventive measures, as part of standard healthcare for employees. Material and Methods: The study was conducted among 362 OMPs. The interviews were carried out by the computer assisted telephone interview (CATI) method. Results: Over 60% of the surveyed OMPs are ready to implement cancer preventive activities among employees. The doctors with the longest seniority in occupational health services are more likely to declare unwillingness to implement cancer preventive activities. Patient's consent, informing women about the program and adjusting the time of the medical visit are the most important conditions for introducing cancer prevention programs by OMPs. Neither seniority nor the number of examinations performed by a physician influenced the currently implemented cancer preventive activities as part of occupational health services (including the evaluation of cancer risk factors occurrence among employees). Conclusions: In Poland, OMPs are willing to implement cancer preventive activities among employees, but their current activity in this area is limited and needs development. The most specific actions should be addressed to doctors with the longest seniority in occupational health services, who are frequently unwilling to implement cancer preventive activities. Strengthening the preventive potential of Polish occupational health services requires a systemic approach to the scope and way of action of healthcare professionals. Int J Occup Med Environ Health. 2021;34(6)

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Section: Discussionmentioning

confidence: 99%

The role of occupational health services in cancer prevention – which factors determine the implementation of preventive measures?

Wiszniewska¹,

Marcinkiewicz²,

Lipińska‐Ojrzanowska³

et al. 2021

Int J Occup Med Environ Health

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“…This effort has resulted in articles published in prestigious journals, high representation at the most important oncology conferences, and recognition within the oncology community as one of the foremost collaborative groups in cancer research worldwide ( http://www.cecog.org ). 10 …”

Section: Cancer Research Worldwidementioning

confidence: 99%

Cancer clinical research in Latin America: current situation and opportunities. Expert opinion from the first ESMO workshop on clinical trials, Lima, 2015

et al. 2016

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Latin America and the Caribbean have not yet developed strong clinical cancer research programmes. In order to improve this situation two international cancer organisations, the Latin American Society of Clinical Oncology (SLACOM) and the European Society of Medical Oncology (ESMO) worked closely with the Peruvian Cooperative Oncology Group (GECOPERU) and organised a clinical cancer research workshop held in Lima, Peru, in October 2015. Many oncologists from different Latin American countries participated in this gathering. The opportunities for and strengths of clinical oncology research in Latin American and Caribbean countries were identified as the widespread use of the Spanish language, the high cancer burden, growing access to information, improving patient education, access to new drugs for research centres, regional networks and human resources. However, there are still many weaknesses and problems including the long timeline for regulatory approval, lack of economic investment, lack of training and lack of personnel participating in clinical research, lack of cancer registries, insufficient technology and insufficient supplies for the diagnosis and treatment of cancer, few cancer specialists, low general levels of education and the negative attitude of government authorities towards clinical research.

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Dynamic response of cancer under the influence of immunological activity and therapy

Vladar¹,

González

2004

Journal of Theoretical Biology

106

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The dynamical basis of tumoral growth has been controversial. Many models have been proposed to explain cancer development. The descriptions employ exponential, potential, logistic or Gompertzian growth laws. Some of these models are concerned with the interaction between cancer and the immunological system. Among other properties, these models are concerned with the microscopic behavior of tumors and the emergence of cancer. We propose a modification of a previous model by Stepanova, which describes the specific immunological response against cancer. The modification consists of the substitution of a Gompertian law for the exponential rate used for tumoral growth. This modification is motivated by the numerous works confirming that Gompertz's equation correctly describes solid tumor growth. The modified model predicts that near zero, tumors always tend to grow. Immunological contraposition never suffices to induce a complete regression of the tumor. Instead, a stable microscopic equilibrium between cancer and immunological activity can be attained. In other words, our model predicts that the theory of immune surveillance is plausible. A macroscopic equilibrium in which the system develops cancer is also possible. In this case, immunological activity is depleted. This is consistent with the phenomena of cancer tolerance. Both equilibrium points can coexist or can exist without the other. In all cases the fixed point at zero tumor size is unstable. Since immunity cannot induce a complete tumor regression, a therapy is required. We include constant-dose therapies and show that they are insufficient. Final levels of immunocompetent cells and tumoral cells are finite, thus post-treatment regrowth of the tumor is certain. We also evaluate late-intensification therapies which are successful. They induce an asymptotic regression to zero tumor size. Immune response is also suppressed by the therapy, and thus plays a negligible role in the remission. We conclude that treatment evaluation should be successful without taking into account immunological effects.

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Cancer clinical trials in Central and Eastern Europe: historical review

Cited by 7 publications

References 6 publications

The role of occupational health services in cancer prevention – which factors determine the implementation of preventive measures?

The role of occupational health services in cancer prevention – which factors determine the implementation of preventive measures?

Cancer clinical research in Latin America: current situation and opportunities. Expert opinion from the first ESMO workshop on clinical trials, Lima, 2015

Dynamic response of cancer under the influence of immunological activity and therapy

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