Cancer Chemotherapy by Arterial Infusion

Benson, Jerrel W.

doi:10.1001/archsurg.1963.01310130127017

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Methods O F Arterial Infusion Chemotherapy1

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1964

1972

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Cited by 19 publications

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“…Methods of infusing Methotrexate for tumors of the head and neck as referred to in this report arc previously published [2]. In brief, Methotrexate, in the dose of 50 mg/24 h was administered in a liter of dextrose or saline solution containing Heparin, 2,000 units, by continuous infusion via electrical pump.…”

Section: Methods O F Arterial Infusion Chemotherapymentioning

confidence: 99%

Regional Chemotherapy and Local Cryotherapy for Cancer

Benson

1972

Oncology

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The rationale for freezing carcinoma adjunctively with chemotherapy is synthesized from published data on tumor cytokinetics, regional chemotherapy, cryopathology, and the microvascular hemodynamics of proliferating tumors. Acute cryolesions in the dog’s tongue, arterially infused with methylene blue solution demonstrated early central ischemia, increasing porosity of marginal circulation and extravascular trapping of dye for 5 h. The dog intestine tolerated transmural cryonecrosis without perforation. 27 patients with cancer of the oral cavity received Methotrexate arterial infusion with cryosurgery without complications since May 1969. Bleeding with later surgery occurred in 2 patients, and a possible relationship to cryosurgery is discussed.

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Section: Methods O F Arterial Infusion Chemotherapymentioning

confidence: 99%