Cancer Chemopreventive Potential of Epidermal Growth Factor Receptor Inhibitors from Natural Products

Bach, Duc-Hiep; Kim, Donghwa; Lee, Sang Kook

doi:10.1007/978-3-030-39855-2_14

Cited by 1 publication

(1 citation statement)

References 98 publications

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“…[66][67][68][69][70] Dichloromethane and methyl alcohol extracts of Seriphidium herba-alba have been proposed as cancer chemopreventive agents against human breast cancer and hepatocellular carcinoma cells. 71 Artesunate, curcumin, resveratrol, magnolol, and fucoxanthin, have been proposed to control the epidermal growth factor receptor (EGFR) 72 and thus work as chemopreventive agents.…”

Section: Direct Chemopreventive Agentsmentioning

confidence: 99%

Natural Products as Cancer Chemo Preventive Agents: Where We Stand

Boretti¹

2022

Natural Product Communications

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This work briefly reviews cancer chemoprevention. This is a very challenging field, as products with a high level of toxicity such as chemotherapeutic agents may be proposed and accepted only under life-threatening conditions. Cancer chemoprevention is otherwise limited to completely safe substances, preferably having neither toxic nor side effects, administered in relatively low amounts. Phases of clinical trials, therapeutic end-points, and biomarkers of chemoprevention are difficult to be defined. The clinical trials needed to prove the efficacy of chemopreventive agents must be very long and extremely widespread to achieve significance, with many variables difficult to control, and therefore subjected to many confounding factors. This makes them almost impossible. It is, therefore, no surprise, if the progress of chemoprevention has been so far very limited. There are only a few examples of direct use of chemopreventive agents, under investigation, but with anything but established protocols, in addition to indirect uses such as general supplementation with antioxidant, anti-inflammatory, and immune-supportive agents. Cancer chemoprevention remains a potentially very rewarding approach, certainly worth further study, but extremely difficult to pursue, in need of different methodological approaches to producing valuable chemopreventive compounds of clear dosages and benefits.

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Section: Direct Chemopreventive Agentsmentioning

confidence: 99%

Natural Products as Cancer Chemo Preventive Agents: Where We Stand

Boretti¹

2022

Natural Product Communications

View full text Add to dashboard Cite

show abstract

Cancer Chemopreventive Potential of Epidermal Growth Factor Receptor Inhibitors from Natural Products

Cited by 1 publication

References 98 publications

Natural Products as Cancer Chemo Preventive Agents: Where We Stand

Natural Products as Cancer Chemo Preventive Agents: Where We Stand

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