Cancer chemopreventive activity of serratane-type triterpenoids on two-stage mouse skin carcinogenesis

Glycyrrhizin exhibits potential chemopreventive activity on 12-O-tetradecanoyl phorbol-13-acetate-induced cutaneous oxidative stress and tumor promotion in swiss albino mice

“…Diets containing an abundance of fruits & vegetables are protective against a variety of diseases, particularly cardiovascular disease and cancer [21,22]. Triterpenoids, a major group of phytochemicals, have also been reported to have anticarcinogenic effects [23] although the mechanisms by which they display anticarcinogenic effects are not clear.…”

Cancer Chemopreventive Activity of Lupane‐ and Oleanane‐Type Triterpenoids from the Cones of Liquidamber styraciflua

“…In the search for biologically active constituents from natural sources, we previously reported some compounds showing significant anti-tumor promoting activities in an in vivo two-stage mouse-skin carcinogenesis assay using 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA): abiesenonic acid methyl ester, a chemical derivative of abieslactone isolated from the stem bark of Abies species (Pinaceae) [3], (11E)-15,16-bisnor-13-oxolabda-8(17),11-dien-19-oic acid [4] and (11Z,13E)-15-oxolabda-8(17),11,13-trien-19-oic acid [5], diterpenoids isolated from the stem bark of Thuja standishii (Cupressaceae; Japanese name: Kurobe), and 13a,14a-epoxy-3b-methoxyserratan-21b-ol and 21a-hydroxy-3b-methoxyserrat-14-en-29-al [6], serrat-14-en-3b,21b-diol [7], 13a,14a-epoxy-21a-methoxyserratan-3-one, and 21a-hydroxy-3b-methoxyserrat-14-en-30-al [8], and 3b-methoxyserrat-14-en-21b-ol [9] from the bark of Picea jezoensis (Sieb. et Zucc.)…”

Hybrids of 3α-methoxyserrat-14-en-21β-ol (PJ-1) and 3β-methoxyserrat-14-en-21β-ol (PJ-2) and various anti-oxidants as cancer chemopreventive agents

“…In our fervent search for biologically active constituents from natural sources, we previously reported several serratane-type triterpenoids that show significant anti-tumor promoting activities in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. These include 3a-methoxyserrat-14-en-21b-ol (1) [5], 13a,14a-epoxy-3b-methoxyserratan-21b-ol and 21a-hydroxy-3b-methoxyserrat-14-en-29-al [6], serrat-14-en-3b,21b-diol [7], and 14b,15b-epoxy-3b-methoxyserratan-21b-ol [8], which were isolated from the bark of Picea jezoensis (Sieb. et Zucc) Carr.…”