Cancer chemoprevention research with selenium in the post-SELECT era: Promises and challenges

Lü, Junxuan; Zhang, Jinhui; Jiang, Cheng; Deng, Yibin; Özten, Nur; Bosland, Maarten C.

doi:10.1080/01635581.2016.1105267

Cited by 64 publications

(43 citation statements)

References 101 publications

(145 reference statements)

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“…No other bioselenocompounds induced the cell proliferation. MeSeCys is a promising agent in cancer prevention and treatment [19]. It is reported that S -methylcysteine (MeCys) exerts a chemopreventive effect [20].…”

Section: Discussionmentioning

confidence: 99%

Bioavailability Comparison of Nine Bioselenocompounds In Vitro and In Vivo

Takahashi

Suzuki

Ogra

2017

IJMS

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Selenium (Se) shows biologically ambivalent characteristics in animals. It is an essential element but becomes severely toxic when the amount ingested exceeds the adequate intake level. Its biological, nutritional, and toxicological effects are strongly dependent on its chemical form. In this study, we evaluated the toxicity and bioavailability of nine naturally occurring Se compounds, or the so-called bioselenocompounds, in vivo and in vitro. Selenite and selenocystine showed higher toxicity than the other bioselenocompounds in vitro. In an in vitro membrane permeability study using Caco-2 cells, selenomethionine and Se-methylselenocysteine were more efficiently transported than the other bioselenocompounds. The effect of bioselenocompounds on nutritional availability was quantitatively determined from the recovery of serum selenoproteins in Se-deficient rats by speciation analysis. In contrast to the in vitro study, there were no significant differences in the assimilation of Se into serum selenoproteins among the bioselenocompounds, including selenoamino acids, selenosugar, and inorganic Se species, such as selenite, selenate, and selenocyanate, except trimethylselenonium ion. These results indicate that animals can equally assimilate both inorganic and organic naturally occurring selenocompounds except trimethylselenonium ion, which is the urinary metabolite of excess Se. We confirmed that the bioselenocompounds except trimethylselenonium ion had equivalent nutritional availabilities.

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Section: Discussionmentioning

confidence: 99%

Bioavailability Comparison of Nine Bioselenocompounds In Vitro and In Vivo

Takahashi

Suzuki

Ogra

2017

IJMS

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“…Se can potentially help in switching the arachidonic acid pathway from pro-inflammatory expression to anti-inflammatory responses and reduce the risk of cancer (Lu et al, 2015), arthritis (Onal, Naziroglu, Colak, Bulut, & Flores-Arce, 2011), and other cardiovascular diseases (Bukkens et al, 2013). In recent past, our group has been reported the significant hyperaccumulation of Se in staple crops ranging from 20 to 123 µg/g in wheat, maize and rice matrices (Dhanjal, Sharma, & Nagaraja, 2016).…”

Section: Introductionmentioning

confidence: 99%

Selenium supplementation through Se-rich dietary matrices can upregulate the anti-inflammatory responses in lipopolysaccharide-stimulated murine macrophages

Dhanjal

Sharma

Prabhu

et al. 2017

Food and Agricultural Immunology

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The accessibility of selenium from naturally enriched sources such as cereals crops can potentially be used as selenium supplements to support nutritional requirements. Dietary selenium supplementation, as Se-rich wheat extracts, on RAW264.7 macrophage cells enhanced the antioxidant capacity via augmentation of cellular selenoprotein glutathione peroxidase 1 (GPx-1) expression in the absence or presence of lipopolysaccharide (LPS) treatment. Cells were supplemented with Se in the form of sodium selenite (SS), seleniferous wheat extract (SeW) and seleniferous wheat extract with rMETase treatment (SeW+rMET) at three different concentrations. Cells supplemented with SS and SeW+rMET showed increase in GPx-1 expression as compared to SeW treated cells. SeW+rMET, further, down-regulated the LPS-induced expression of cyclooxygenase-2, microsomal PGE synthase-1 and inducible nitric oxide synthase w.r.t. Se-deficient cells, while the expression of hematopoietic PGD synthase was upregulated. This demonstrates SeSup effectively modulates the expression inflammatory responses, indicating the potential benefits of dietary selenium supplementation.

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“…Intake and status of selenium in most European countries are relatively low as compared to the USA [10, 12]. This supports further exploration of the role of selenium for prostate cancer prevention in these populations with marginal selenium status [11]. Rather than initiating another large intervention trial, we advocate to first gain further insight into the mechanisms underlying the role of selenium in cancer biology and other health related outcomes.…”

Section: Introductionmentioning

confidence: 87%

A short-term intervention with selenium affects expression of genes implicated in the epithelial-to-mesenchymal transition in the prostate

et al. 2017

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In parallel with the inconsistency in observational studies and chemoprevention trials, the mechanisms by which selenium affects prostate cancer risk have not been elucidated. We conducted a randomized, placebo-controlled trial to examine the effects of a short-term intervention with selenium on gene expression in non-malignant prostate tissue. Twenty-three men received 300 μg selenium per day in the form of selenized yeast (n=12) or a placebo (n=11) during 5 weeks. Prostate biopsies collected from the transition zone before and after intervention were analysed for 15 participants (n=8 selenium, n=7 placebo). Pathway analyses revealed that the intervention with selenium was associated with down-regulated expression of genes involved in cellular migration, invasion, remodeling and immune responses. Specifically, expression of well-established epithelial markers, such as E-cadherin and epithelial cell adhesion molecule EPCAM, was up-regulated, while the mesenchymal markers vimentin and fibronectin were down-regulated after intervention with selenium. This implies an inhibitory effect of selenium on the epithelial-to-mesenchymal transition (EMT). Moreover, selenium was associated with down-regulated expression of genes involved in wound healing and inflammation; processes which are both related to EMT. In conclusion, our explorative data showed that selenium affected expression of genes implicated in EMT in the transition zone of the prostate.

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Cancer chemoprevention research with selenium in the post-SELECT era: Promises and challenges

Cited by 64 publications

References 101 publications

Bioavailability Comparison of Nine Bioselenocompounds In Vitro and In Vivo

Bioavailability Comparison of Nine Bioselenocompounds In Vitro and In Vivo

Selenium supplementation through Se-rich dietary matrices can upregulate the anti-inflammatory responses in lipopolysaccharide-stimulated murine macrophages

A short-term intervention with selenium affects expression of genes implicated in the epithelial-to-mesenchymal transition in the prostate

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