Cancer Chemoprevention by Polyphenols and Their Potential Application as Nanomedicine

Tabrez, Shams; Priyadarshini, Medha; Urooj, Maryam; Shakil, Shazi; Ashraf, Ghulam Md; Khan, Mohd Shahnawaz; Kamal, Mohammad Amjad; Alam, Qamre; Jabir, Nasimudeen R.; Abuzenadah, Adel M.; Chaudhary, Adeel; Damanhouri, Ghazi A.

doi:10.1080/10590501.2013.763577

Cited by 61 publications

(54 citation statements)

References 186 publications

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“…Additionally, the mean BMI of breast cancer patients was 25.0 kg/m 2 , which was equal to the level of obese people. These results were consistent with other studies .…”

Section: Discussionsupporting

confidence: 94%

Low BMI is correlated with increased TGF‐β and IL‐10 mRNA levels in the peripheral blood of breast cancer patients

et al. 2018

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Transforming growth factor-β (TGF-β), interleukin-10 (IL-10), and forkhead box P3 (Foxp3) have important roles in breast cancer development. Previous studies confirmed a correlation between these immune molecules and tumor characteristics, but their association with nutritional status in breast cancer is largely unknown. We aimed to investigate the association between body mass index (BMI), hemoglobin, total protein, albumin, globulin (GLB), albumin/GLB ratio (AGR), pre-albumin, prognostic nutritional index, and TGF-β, IL-10, and Foxp3 mRNA expression in patients with breast cancer. Quantitative real-time PCR was used to detect the mRNA expression of TGF-β, IL-10, and Foxp3 in the peripheral blood of 107 patients with breast cancer and 21 healthy controls. We found that TGF-β mRNA levels were 2.6-fold, 3.2-fold, and 2.3-fold higher in patients with low BMI (<23), low AGR, and high GLB, respectively, than in their counterparts (P < 0.05). In addition, IL-10 mRNA expression levels in patients with normal BMI (<23) were 2.8-fold and 3.5-fold higher than in those who were overweight (23≤ BMI <25) and obese (BMI ≥ 25), respectively (P < 0.05). In addition, TGF-β, IL-10, and Foxp3 mRNA levels were significantly higher in patients with breast cancer than in healthy controls (P < 0.05). In summary, our results suggest that nutritional status, especially BMI, may strongly affect systematic immune function in patients with breast cancer. © 2018 IUBMB Life, 70(3):237-245, 2018.

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“…Additionally, the mean BMI of breast cancer patients was 25.0 kg/m 2 , which was equal to the level of obese people. These results were consistent with other studies .…”

Section: Discussionsupporting

confidence: 94%

Low BMI is correlated with increased TGF‐β and IL‐10 mRNA levels in the peripheral blood of breast cancer patients

et al. 2018

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“…Table I shows that the preliminary phytochemical analysis of H-PIRE revealed a high content of phenols, flavonoids and proanthocyanidins, which are biologically active phytochemical compounds found in many medicinal herbal extracts. Secondary metabolites such as polyphenols and flavonoids interact with proteins and are useful for inhibiting multidrug resistance (25), suppressing tumor angiogenesis and preventing inflammation (26). Thus, the phytochemical composition of H-PIRE was consistent with the reported medicinal properties of P. indica.…”

Section: Resultssupporting

confidence: 67%

Hexane fraction of Pluchea indica root extract inhibits proliferation and induces autophagy in human glioblastoma cells

et al. 2017

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Abstract. Pluchea indica (L.) Less. is a perennial plant known for its versatile uses in traditional medicine. Previous findings have shown that the extracts of Pluchea indica possess significant anti-inflammatory, anti-ulcer and anti-tuberculosis activity. The aim of this study was to demonstrate the anticancer activity of the hexane fraction of P. indica root extract (H-PIRE) in human glioblastoma cells using flow cytometric and western blot analysis. The results shoewd that, H-PIRE suppressed the growth of glioblastoma cells in a dose-dependent manner. H-PIRE treatment markedly decreased the population of cells in S and G2/M phases. The significant upregulation of acidic vesicular organelle (AVO) was detected during H-PIRE treatment. The expression levels of microtubule-associated light chain 3-II (LC3-II) protein, phosphorylated JNK and phosphorylated p38 were significantly increased, confirming the occurrence of autophagy during the process. Finally, the combination treatment of H-PIRE and LY294002, a pan PI3K inhibitor, further decreased cell viability, suggesting an additive anticancer effect. Taken together, our results suggest that H-PIRE suppresses the proliferation of glioblastoma cells by inducing cell cycle arrest and autophagy.

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“…Encapsulating polyphenols in nanoparticles could enhance their biodistribution, solubility, and stability in the human body, while reducing their intense metabolism. Moreover, conjugating nanoparticles containing a specific polyphenol with an appropriate anticancer drug may improve internalization of these natural compounds into cancer cells, leading to improved anticancer activity [164]. Several studies have reported that nanotechnology enhanced ability of CUR to counteract the growth of various tumors.…”

Section: Nanotechnology and Polyphenolsmentioning

confidence: 99%

“…In this regard, several preclinical studies reported that the encapsulation of polyphenols in small nanoparticles enhanced their bioavailability and antitumor activity [152,153,154,155,156,164]. …”

Section: Perspective and Conclusionmentioning

confidence: 99%

In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment

Fantini

Benvenuto

Masuelli

et al. 2015

IJMS

280

236

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Carcinogenesis is a multistep process triggered by genetic alterations that activate different signal transduction pathways and cause the progressive transformation of a normal cell into a cancer cell. Polyphenols, compounds ubiquitously expressed in plants, have anti-inflammatory, antimicrobial, antiviral, anticancer, and immunomodulatory properties, all of which are beneficial to human health. Due to their ability to modulate the activity of multiple targets involved in carcinogenesis through direct interaction or modulation of gene expression, polyphenols can be employed to inhibit the growth of cancer cells. However, the main problem related to the use of polyphenols as anticancer agents is their poor bioavailability, which might hinder the in vivo effects of the single compound. In fact, polyphenols have a poor absorption and biodistribution, but also a fast metabolism and excretion in the human body. The poor bioavailability of a polyphenol will affect the effective dose delivered to cancer cells. One way to counteract this drawback could be combination treatment with different polyphenols or with polyphenols and other anti-cancer drugs, which can lead to more effective antitumor effects than treatment using only one of the compounds. This report reviews current knowledge on the anticancer effects of combinations of polyphenols or polyphenols and anticancer drugs, with a focus on their ability to modulate multiple signaling transduction pathways involved in cancer.

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Cancer Chemoprevention by Polyphenols and Their Potential Application as Nanomedicine

Cited by 61 publications

References 186 publications

Low BMI is correlated with increased TGF‐β and IL‐10 mRNA levels in the peripheral blood of breast cancer patients

Low BMI is correlated with increased TGF‐β and IL‐10 mRNA levels in the peripheral blood of breast cancer patients

Hexane fraction of Pluchea indica root extract inhibits proliferation and induces autophagy in human glioblastoma cells

In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment

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