Cancer Cell Properties

Heinen, Christopher D.; Steigerwald, Kira; Goss, Kathleen H.; Groden, Joanna

doi:10.1016/b978-012656976-6/50159-1

Cell Physiology Source Book 2001

DOI: 10.1016/b978-012656976-6/50159-1

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Cancer Cell Properties

Christopher D. Heinen

Kira Steigerwald

Kathleen H. Goss

et al.

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2002

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“…We report a global gene expression pro®ling approach used to identify gene expression di erences within a panel of MIN and CIN cell lines (selected on the basis of Heinen et al, 1995). This utilized Gene Discovery Array (GDA) v1.3 ®lters (IncyteGenomics, USA) and SMART cDNA (Clontech, USA) to determine expression di erences between MIN (LS174T, SW48 and HCT116) and CIN (Caco2, SW480 and HT29) sporadic colorectal cancer cell lines.…”

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confidence: 99%

Gene expression differences between the microsatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by high-density cDNA array hybridization

et al. 2002

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Two distinct pathways of tumorigenesis exist in sporadic colorectal cancer. The microsatellite instability pathway (MIN), which is characterized by widespread microsatellite instability due to aberrant mismatch repair machinery, accounts for 15% of all sporadic colorectal cancers. The chromosomal instability (CIN) phenotype, which accounts for 85% of sporadic colorectal cancers, is characterized by gross chromosomal lesions but the underlying mechanism remains unclear. We have addressed di erences in gene expression between the MIN and CIN colorectal cancer phenotypes in vitro by the use of high density cDNA ®lters to compare gene expression patterns between MIN and CIN colorectal cancer cell-lines yielding a panel of 73 consistently di erentially expressed genes. Nine of these genes were subjected to con®rmatory analysis by independent methods, of which six were con®rmed as being di erentially expressed; PLK, RanBP2 and CCNA2 were overexpressed in CIN lines while BTF3, H2AZ and PTPD1 were overexpressed in MIN lines. These six genes are involved in diverse processes, such as maintenance of chromatin architecture, DNA-damage checkpoint and cell cycle regulation, which may contribute to the CIN and MIN phenotypes.

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Gene expression differences between the microsatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by high-density cDNA array hybridization

et al. 2002

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Cancer Cell Properties

Cited by 1 publication

References 70 publications

Gene expression differences between the microsatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by high-density cDNA array hybridization

Gene expression differences between the microsatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by high-density cDNA array hybridization

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