2019
DOI: 10.1016/j.colsurfb.2018.12.038
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Cancer cell membrane-cloaked mesoporous silica nanoparticles with a pH-sensitive gatekeeper for cancer treatment

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Cited by 97 publications
(59 citation statements)
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“…Parodi et al (2013) have shown that coating nanoporous silicon particles with a cell membrane which is purified from leukocytes can prevent the nano-carrier from clearance by phagocytes, and the characteristics of this hybrid particle allow the drug to have extended time period in circulation, leading to increased accumulation in the tumor. Similarly, some studies have utilized cancer cell membrane-cloaked mesoporous silica NPs for cancer treatment, which improves the stability and targeting ability of nano-carriers (Liu et al, 2019). Moreover, the development of dual-membrane coated NPs can further enhance the function of NPs.…”
Section: Hybrid Npsmentioning
confidence: 99%
“…Parodi et al (2013) have shown that coating nanoporous silicon particles with a cell membrane which is purified from leukocytes can prevent the nano-carrier from clearance by phagocytes, and the characteristics of this hybrid particle allow the drug to have extended time period in circulation, leading to increased accumulation in the tumor. Similarly, some studies have utilized cancer cell membrane-cloaked mesoporous silica NPs for cancer treatment, which improves the stability and targeting ability of nano-carriers (Liu et al, 2019). Moreover, the development of dual-membrane coated NPs can further enhance the function of NPs.…”
Section: Hybrid Npsmentioning
confidence: 99%
“…In comparison to free DOX, MSN/DOX@CaCO3@CM NPs exhibited increased cell uptake and induced higher rates of apoptotic death in prostate cancer cells. In vivo experiments demonstrated that the NPs had remarkable antitumor effects and suppressed tumor growth [56]. Overall, this study demonstrated that coupling the increased localization of CCNPs in tumor microenvironments with pH-stimulated release of chemotherapeutic drugs is a potent strategy to enhance therapeutic ratios.…”
Section: Drug Deliverymentioning
confidence: 71%
“…This will facilitate proper orientation of the membrane around the NP owing to electrostatic repulsion between the NP surface and negative extracellular membrane components [27]. To date, the types of synthetic NPs that have been wrapped with cell-derived membranes for cancer therapies include nanocrystals [54], nanocages [42], mineral-based or mesoporous silica [35,49,[55][56][57][58], polymeric cores [30,40,45,[59][60][61][62][63][64], organic and inorganic metal frameworks [44,51,[65][66][67], protein cores [68,69], and gold-based or magnetic nanoparticles [70][71][72] (Figure 4, Table 1). Poly(lactic-co-glycolic) acid (PLGA) is one of the most widely used NP cores due to its biodegradability, FDA approval, and ability to encapsulate many products [17][18][19].…”
Section: Selection Of Nanoparticle Corementioning
confidence: 99%
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