Cancer Cell Growth in the Near Infrared Region by Using Silica Coated Gold Nanorods

Abstract

Gold nanorods (AuNRs) have been considered as suitable materials for diverse biomedical applications in controlling cell behaviors. The nanoisland system with well-dispersed silica coated Au nanorods (Si-AuNRs) was used to demonstrate the enhanced cell growth of normal and cancer cells (MDA-MB-231 mammalian breast cancer cells) from the induced expressions of the heat shock proteins (HSPs). The over-expressions of HSP could help in protein folding in cell proliferations and growths of both the normal and cancer cells. In the current study, interesting mechanisms of cancer cell growth with Si-AuNRs than the conventional systems, such as incubator, would be presented. We believe that the growth of cancer cells in near infrared (NIR) region using Si-AuNRs induced the activities of HSPs, which could help the protein folding in cell growth and survival in comparison to the cells grown in the incubator only. The cell growth enhancing technology could be expanded in diverse applications in cell culture systems.

Recent Advances in Synergistic Effect of Nanoparticles and Its Biomedical Application

“…As shown in Figure 1 , synergistic multimodal cancer diagnostics and gene suppression are potential mechanisms for cancer apoptosis (c). Silica-coated Au nanorods showed promise for cancer applications in recent research [ 14 ].…”

“…As shown in Figure 1, synergistic multimodal cancer diagnostics and gene suppression are potential mechanisms for cancer apoptosis (c). Silica-coated Au nanorods showed promise for cancer applications in recent research [14]. The promise of nanotechnology goes beyond the applications in medicine and encompasses all aspects of human life.…”

Upper-critical solution temperature (UCST) polymer functionalized nanomedicine for controlled drug release and hypoxia alleviation in hepatocellular carcinoma therapy

“…Gold nanorods (AuNRs), as a kind of typical PTT reagent, have transverse surface plasmon resonance (TSPR) and longitudinal surface plasmon resonance (LSPR) [ 13 ]. By adjusting the aspect ratio of AuNRs, the plasmon resonance was red-shifted to the near infrared region, facilitating the PTT with deep tissue penetration [ 14 ]. In addition, compared with other shapes of gold nanomaterials, it not only has higher photothermal conversion efficiency, but also a larger photoacoustic absorption interface, resulting in stronger photoacoustic signals under the same excitation conditions.…”

Gold-Nanorod-Based Scaffolds for Wound-Healing Applications

“…3 Conversely, gold nanorods (GNRs) have attracted a great deal of interest because of their reproducible synthetic and surface functionalization routes, excellent optical properties, and biocompatibility. 4,5 It has been a great challenge to find an appropriate healing method for skin injury, generating advanced and new healing materials. Wounds are always caused by the mechanical attack of the anatomical structure and function of the epidermal tissue.…”

“…Gold nanoparticles (GNPs) have been utilized in broad areas, including chemical, biomedical, optoelectronics, and energy devices. , GNPs play essential roles in the biological domain because of their facile synthesis, biocompatibility, and low toxicity achieved effectively through surface passivation . Conversely, gold nanorods (GNRs) have attracted a great deal of interest because of their reproducible synthetic and surface functionalization routes, excellent optical properties, and biocompatibility. , …”