Cancer cachexia syndrome: Reflecting on 20 years of providing cancer cachexia care as the leader of an interdisciplinary team in an Australian cancer center

Martin, Peter

doi:10.1016/j.apjon.2022.04.009

Cited by 1 publication

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cancer-associated adipocytes have been found to promote lipid accumulation ( 35 ). In the case of malignant melanoma, the tumor secreted an inhibitor of adipose LPL termed melanoma cachexia factor, which caused the inhibition of extracellular lipolysis ( 36 ). Activation of the transmembrane channel for exogenous free fatty acid uptake (CD36) and LPL (a key enzyme for extracellular lipolysis) confirmed the disposition of extracellular lipid stores and lipolysis in cells.…”

Section: Discussionmentioning

confidence: 99%

Overcharged lipid metabolism in mechanisms of antitumor by Tremella fuciformis‑derived polysaccharide

Pan

2022

Int J Oncol

View full text Add to dashboard Cite

Tremella fuciformis-derived polysaccharide (TFP) is a natural macromolecular compound that is well known for whitening skin, as well as for its ability to regulate lipids and immunity. However, its mechanism of action is not clear. In the present study, B16 cells treated with TFP were inoculated subcutaneously in the right flank of C57BL/6 mice to explore the effect of TFP on melanoma in vivo. Western blotting, immunohistochemistry, immunofluorescence staining and transcription analysis of tumors were utilized to assess the expression of key molecules in production of melanin, lipid metabolism and immunity. It was found that TFP promoted B16 cell apoptosis and induced G 2 /M cell cycle arrest, which was associated with activation of cell cycle-related pathways. TFP induced the expression of glucose transporter type 4 and CD36, thus resulting in an increase in the uptake of lipids, which markedly suppressed sterol regulatory element-binding transcription factor 1 and phosphorylated-AMP-activated protein kinase expression; increased the number of lipids in the cell membrane, endoplasmic reticulum and nucleus; and induced the RNA expression of molecules related to lipid metabolism, as revealed by RNA-sequencing in vivo. Increased lipid binding, upregulated lipid storage, and elevated triglyceride and lipid catabolism resulted in disruption of cell volume homeostasis and activated innate immune response, thus inhibiting melanoma development and progression. These data revealed a novel molecular mechanism involved in the antitumor effect of TFP via lipid metabolism.

show abstract

Section: Discussionmentioning

confidence: 99%

Overcharged lipid metabolism in mechanisms of antitumor by Tremella fuciformis‑derived polysaccharide

Pan

2022

Int J Oncol

View full text Add to dashboard Cite

show abstract

Cancer cachexia syndrome: Reflecting on 20 years of providing cancer cachexia care as the leader of an interdisciplinary team in an Australian cancer center

Cited by 1 publication

References 25 publications

Overcharged lipid metabolism in mechanisms of antitumor by Tremella fuciformis‑derived polysaccharide

Overcharged lipid metabolism in mechanisms of antitumor by Tremella fuciformis‑derived polysaccharide

Contact Info

Product

Resources

About