Cancer cachexia

Tisdale, M. J.

doi:10.1038/bjc.1991.80

Cited by 69 publications

(44 citation statements)

References 39 publications

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“…Normally, the concentration of circulating TNF-· is undetectable by conventional bioassays. In patients with cancers, TNF-· appears to be overproduced and involved in metabolic disorder associated with cancers [1]. This notion is consistent with the observation that TNF-· impairs nutrient metabolism in vitro and in vivo in laboratory animals [2][3][4].…”

Section: Introductionsupporting

confidence: 77%

Resection of pancreatic cancer normalizes the preoperative increase of tumor necrosis factor alpha gene expression

Ariapart¹,

Bergstedt‐Lindqvist²,

Harmelen

et al. 2002

Pancreatology

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Section: Introductionsupporting

confidence: 77%

Resection of pancreatic cancer normalizes the preoperative increase of tumor necrosis factor alpha gene expression

Ariapart¹,

Bergstedt‐Lindqvist²,

Harmelen

et al. 2002

Pancreatology

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“…Furthermore, catabolic factors are associated with the existence of cancer cachexia. Apart from necrosis factors associated with reduction in food and water intake, other catabolic factors, produced by the tumour itself, are present in the circulation of patients with cancer cachexia [1,11]. Proinflammatory cytokines are thought to play an important role in cachexia.…”

Section: Discussionmentioning

confidence: 99%

Peroneal nerve neuropathy in cancer patients: a paraneoplastic syndrome?

Koehler¹,

Buscher

Rozeman³

et al. 1997

Journal of Neurology

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The occurrence of PN seems to be higher in patients with cancer than in people without cancer. Cancer was found in patients with PN more often, particularly in elderly men, than would be expected from the occurrence in the total population. PN in patients with cancer is supposed to be due to a combination of metabolic and mechanical factors. The findings justify a prospective study of the relation between PN and cancer.

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“…Cancer cachexia is a complexed pathological state characterized by progressive weight loss, anorexia, asthenia, anemia, and altered metabolic blood parameters, e.g. hypertriglyceridemia and hypoglycemia (12)(13)(14). Weight loss results from catabolism of host body compartments, particularly muscle and adipose tissue.…”

mentioning

confidence: 99%

Molecular Cloning of a Gene Encoding a New Type of Metalloproteinase-disintegrin Family Protein with Thrombospondin Motifs as an Inflammation Associated Gene

Kuno¹,

Kanada

Nakashima

et al. 1997

Journal of Biological Chemistry

458

320

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A cellular disintegrin and metalloproteinase (ADAM) is a new family of genes with structural homology to the snake venom metalloproteinases and disintegrins. We screened genes which were selectively expressed in the cachexigenic colon 26 adenocarcinoma subline in vivo. It was found that one novel cDNA clone, identified as a cachexigenic tumor selective gene, encodes a cysteinerich protein which shows a sequence similarity to that of both the snake venom metalloproteinases and thrombospondins. We named this cDNA clone A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-1). ADAMTS1 consists of six domains, 1) a proand 2) a metalloproteinase, 3) a disintegrin-like, 4) a thrombospondin (TSP) homologous domain containing TSP type I motif, 5) a spacer region, and 6) COOH-terminal TSP submotifs. Unlike other ADAMs, ADAMTS-1 does not possess a transmembrane domain and is a putative secretory protein. Therefore, ADAMTS-1 is a new type of ADAM family protein with TSP type I motifs. We demonstrated that the TSP homologous domain containing the TSP type I motif of ADAMTS-1 is functional for binding to heparin. ADAMTS-1 mRNA could be induced by stimulating colon 26 cells with an inflammatory cytokine, interleukin-1, in vitro. Moreover, intravenous administration of lipopolysaccharide in mice selectively induced ADAMTS-1 mRNA in kidney and heart. These data suggest that ADAM-TS-1 may be a gene whose expression is associated with various inflammatory processes as well as development of cancer cachexia.

show abstract

Cancer cachexia

Cited by 69 publications

References 39 publications

Resection of pancreatic cancer normalizes the preoperative increase of tumor necrosis factor alpha gene expression

Resection of pancreatic cancer normalizes the preoperative increase of tumor necrosis factor alpha gene expression

Peroneal nerve neuropathy in cancer patients: a paraneoplastic syndrome?

Molecular Cloning of a Gene Encoding a New Type of Metalloproteinase-disintegrin Family Protein with Thrombospondin Motifs as an Inflammation Associated Gene

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