Cancer burden with ageing population in urban regions in China: projection on cancer registry data from World Health Organization

Tsoi, Kelvin K.; Hirai, Hoyee W.; Chan, Felix C.H.; Griffiths, Siân; Sung, Joseph J.Y.

doi:10.1093/bmb/ldw050

Cited by 36 publications

(36 citation statements)

References 16 publications

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“…Presently, frequent occurrences of cancers have also become critical public health problems 52 . Biotherapies, such as bacillus Calmette-Guerin (BCG) therapy, have been used for treatment of certain cancers, and brought attractive efficacy, however, new alternative drugs are urgently needed 53 .…”

Section: Discussionmentioning

confidence: 99%

Production and delivery of Helicobacter pylori NapA in Lactococcus lactis and its protective efficacy and immune modulatory activity

Peng

Zhang

Wang

et al. 2018

Sci Rep

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Helicobacter pylori neutrophil-activating protein A subunit (NapA) has been identified as a virulence factor, a protective antigen and a potent immunomodulator. NapA shows unique application potentials for anti-H. pylori vaccines and treatment strategies of certain allergic diseases and carcinomas. However, appropriate production and utilization modes of NapA still remain uncertain to date. This work has established a novel efficient production and utilization mode of NapA by using L. lactis as an expression host and delivery vector, and demonstrated immune protective efficacy and immune modulatory activity of the engineered L. lactis by oral vaccination of mice. It was observed for the first time that H. pylori NapA promotes both polarized Th17 and Th1 responses, which may greatly affect the clinical application of NapA. This report offers a promising anti-H. pylori oral vaccine candidate and a potent mucosal immune modulatory agent. Meanwhile, it uncovers a way to produce and deliver the oral vaccine and immunomodulator by fermentation of food like milk, which might have striking effects on control of H. pylori infection, gastrointestinal cancers, and Th2 bias allergic diseases, including many food allergies.

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Section: Discussionmentioning

confidence: 99%

Production and delivery of Helicobacter pylori NapA in Lactococcus lactis and its protective efficacy and immune modulatory activity

Peng

Zhang

Wang

et al. 2018

Sci Rep

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“…In China, CRC incidence and mortality rates were estimated to be 27.1 and 13.1 per 100,000 people in 2014 . Recent data have revealed an increasing trend of CRC incidence in China, especially in large urban centers . In Guangzhou, from 2000 to 2011, the CRC incidence increased from 23.4 to 37.5 per 100,000 males and from 20.9 to 30.5 per 100,000 females …”

Section: Introductionmentioning

confidence: 99%

“…3 Recent data have revealed an increasing trend of CRC incidence in China, especially in large urban centers. 4,5 In Guangzhou, from 2000 to 2011, the CRC incidence increased from 23.4 to 37.5 per 100,000 males and from 20.9 to 30.5 per 100,000 females. 6 Early screening has been shown to significantly reduce CRC incidence and mortality, 7 and nationwide CRC screening programs have been implemented in many developed countries.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of a short message service intervention to motivate people with positive results in preliminary colorectal cancer screening to undergo colonoscopy: A randomized controlled trial

Liang

Zhou

et al. 2019

Cancer

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Background Colonoscopy adherence among populations at high risk for colorectal cancer (CRC) is crucial for the early diagnosis and treatment of CRC, but the adherence rate has been found to be poor. A short message service (SMS) is effective in promoting cancer screening, but its effectiveness in promoting colonoscopy among populations at high risk for CRC has not been well studied. Methods In this randomized controlled trial conducted in Guangzhou, China, participants who had tested positive during preliminary CRC screening (a high‐risk factor questionnaire and/or an immunochemical fecal occult blood test) but had not undergone colonoscopy were randomized into low‐frequency (monthly) intervention, high‐frequency (biweekly) intervention, and control groups. The 2 intervention groups received behavioral theory–based SMS for 6 months. Data were obtained from the CRC screening database. The outcome was undergoing a colonoscopy examination. Results For the 1362 participants, the rates of colonoscopy adherence were 5.2%, 6.0%, and 10.5% at month 3 and 7.1%, 9.6%, and 13.7% at month 6 in the control, low‐frequency intervention, and high‐frequency intervention groups, respectively. After adjustments for potential confounders, the high‐frequency intervention group was approximately twice as likely as the control group to undergo colonoscopy (adjusted hazard ratio, 1.99; 95% confidence interval, 1.32‐3.01), whereas the difference between the low‐frequency intervention and control groups was not statistically significant. The cost of SMS to increase colonoscopy uptake by 1 in the high‐frequency intervention group was US $2.7. Conclusions Text messages sent biweekly for 6 months to patients with positive preliminary screening results could increase colonoscopy adherence. SMS could be a prioritized intervention for promoting colonoscopy in large community‐based populations.

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“…96 Thus, currently, gastric cancer is becoming known as a disease of the elderly population in Japan. Since the aged population has been increasing and H. pylori eradication has spread in other East Asian countries, 97,98 this point in time would constitute the "transitional phase" for gastric cancer to become a disease of old age in these countries. Also, in esophageal cancer, age peaks have risen to 70-74 years in 2014, as compared with 60-64 years in 1990.…”

Section: Aging Of Patients With Upper Gi Neoplasia In East Asian Counmentioning

confidence: 99%

Management following endoscopic resection in elderly patients with early‐stage upper gastrointestinal neoplasia

Hatta

Gotoda

Koike

et al. 2020

Digestive Endoscopy

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With the ongoing increase in the aging population in Japan, the number of elderly patients among the total population with upper gastrointestinal (GI) neoplasia has also been increasing. As elderly patients present unique age‐related variations in their physical condition, the therapeutic approach for upper GI neoplasia should be differentiated between elderly and nonelderly patients. According to the existing guidelines, additional treatment is the standard therapy in patients who undergo endoscopic resection (ER) with a possible risk of lymph node metastasis (LNM) for upper GI neoplasia. However, due to the relatively low rate of LNM, applying additional treatment in all elderly patients may be excessive. Although additional treatment has the advantage of reducing cancer‐specific mortality, its disadvantages include deteriorated quality of life, complications, and mortality in surgery. In patients with early gastric cancer, we propose treatment decisions be made using a risk‐scoring system for LNM and upon considering the physical condition of the patient after ER with curability C‐2. In those with superficial esophageal squamous cell carcinoma with a possible risk of LNM after ER, selective chemoradiotherapy may be a less‐invasive treatment option, although the present standard treatment is esophagectomy. When considering the treatment decision, achieving a “cure” of the tumor has been regarded as critical. However, as the main cause of mortality in elderly patients with ER for upper GI neoplasia is noncancer‐related death, both achieving a “cure” and also a good level of “care” is important in the management of elderly patients.

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Cancer burden with ageing population in urban regions in China: projection on cancer registry data from World Health Organization

Cited by 36 publications

References 16 publications

Production and delivery of Helicobacter pylori NapA in Lactococcus lactis and its protective efficacy and immune modulatory activity

Production and delivery of Helicobacter pylori NapA in Lactococcus lactis and its protective efficacy and immune modulatory activity

Effectiveness of a short message service intervention to motivate people with positive results in preliminary colorectal cancer screening to undergo colonoscopy: A randomized controlled trial

Management following endoscopic resection in elderly patients with early‐stage upper gastrointestinal neoplasia

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