Cancer biomarker determination by resonance energy transfer using functional fluorescent nanoprobes

Das, Pradip; Sedighi, Abootaleb; Krull, Ulrich J.

doi:10.1016/j.aca.2018.07.060

Cited by 44 publications

(31 citation statements)

References 170 publications

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“…The Bossmann group has continuously developed their patented technology for ultra-sensitive protease detection since 2007 [27][28][29] . These fluorescence-based optical nanobiosensors are composed of waterdispersible dopamine-coated Fe/Fe 3 O 4 core/shell nanoparticles and an attached Fluorescence resonance energy transfer pair [30] [tetrakis (4-carboxyphenyl) porphyrin (TCPP) and cyanine 5.5]. Both the central nanoparticle and cyanine 5.5 are able to quench photoexcited TCPP, which is attached via a proteasecleavable consensus sequence [4] .…”

Section: Optical Nanobiosensors For Protease Detectionmentioning

confidence: 99%

Early detection of non-small cell lung cancer in liquid biopsies by ultrasensitive protease activity analysis

Udukala¹,

Wendel²,

Wang³

et al. 2020

JCMT

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Aim: A significant fraction of mortalities from non-small cell lung cancer could be prevented, if the cancer would be diagnosed earlier. Nanobiosensors for the ultrasensitive detection of active proteases in serum were designed to detect a significant protease activity signature of non-small cell lung cancer (stage I and higher). Methods: We determined the activity of nine protease biomarkers in the sera of non-small cell lung cancer patients and compared them with the protease activities of a control group of healthy human subjects using optical nanobiosensors. They consist of a central Fe/Fe 3 O 4 core/shell nanoparticle with an attached Fluorescence resonance energy transfer-pair [tetrakis-carboxyphenyl porphyrin (TCPP) and cyanine 5.5]. TCPP is attached to the central nanoparticle via a protease-cleavable tether, whereas cyanine 5.5 is tethered permanently to the dopamine-layer surrounding the nanoparticle. Results: Based on the activity pattern of urokinase plasminogen activator, matrix metalloproteinases 1, 2, 3, 7, 9, and 13, and cathepsins B and L as well, non-small cell lung cancer could be detected at stage I by means of a liquid biopsy.

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Section: Optical Nanobiosensors For Protease Detectionmentioning

confidence: 99%

Early detection of non-small cell lung cancer in liquid biopsies by ultrasensitive protease activity analysis

Udukala¹,

Wendel²,

Wang³

et al. 2020

JCMT

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“…In addition, there are some electrochemical biosensors that can be used to detect biomarkers for disease diagnosis [108]. Cyclooxygenase-2 (COX-2) is an important enzyme in pain biomarkers, inflammation, and cancer cell proliferation.…”

Section: Non-enzyme Electrochemical Sensorsmentioning

confidence: 99%

Electrochemical Sensors Fabricated by Electrospinning Technology: An Overview

Chen

Chou

Liu

et al. 2019

Sensors

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Nanofibers or nanofibrous membranes prepared by electrospinning possess many attractive properties, including excellent mechanical properties, high specific surface area and high porosity, making them attractive for sensor application, especially for the electrochemical sensors. Many nanomaterials are used as additives to improve the conductivity, sensitivity and selectivity of sensors. Based on the different modifiers of electrode materials, electrochemical sensors can be divided into enzyme sensors and non-enzyme sensors. In this review, we summarize the recent progress of the electrochemical sensors fabricated by electrospinning, including hydrogen peroxide (H2O2) sensors, glucose sensors and other sensors. In addition, the sensing mechanisms of various electrochemical sensors are introduced in detail. Finally, future research directions of electrochemical sensors based on electrospinning and the challenges faced by large-scale applications of electrospun electrochemical sensors are presented.

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“…8 The possibility of increasing and controlling the FRET efficiency is promising for the development of many photonic applications, specically for biomedical research. In this regard, one of the most powerful photonic nanotools are oligonucleotide-based molecular beacons, which are used in biosensing and specic gene identication, [10][11][12][13][14][15] RNA imaging, 14,[16][17][18] revealing nucleic acid mutations, 19 monitoring gene expression 20 and protein-protein interactions, 21 nanomedicine, 14,22 cell-surface glycosylation imaging, 23 etc. All these applications are based on the same principle: a specically designed molecular beacon is a circled oligonucleotide, with the donor and acceptor dye molecules conjugated to its ends and located in close vicinity to each other; hence, a strong donor-to-acceptor FRET occurs (Fig.…”

Section: Introductionmentioning

confidence: 99%

Polariton-assisted manipulation of energy relaxation pathways: donor–acceptor role reversal in a tuneable microcavity

et al. 2021

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Cancer biomarker determination by resonance energy transfer using functional fluorescent nanoprobes

Cited by 44 publications

References 170 publications

Early detection of non-small cell lung cancer in liquid biopsies by ultrasensitive protease activity analysis

Early detection of non-small cell lung cancer in liquid biopsies by ultrasensitive protease activity analysis

Electrochemical Sensors Fabricated by Electrospinning Technology: An Overview

Polariton-assisted manipulation of energy relaxation pathways: donor–acceptor role reversal in a tuneable microcavity

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