Cancer-associated mutations in protein kinase C theta are loss-of-function
Stefanie J. Hodapp,
Nathan Gravel,
Natarajan Kannan
et al.
Abstract:The Ca2+-independent, but diacylglycerol-regulated, novel protein kinase C (PKC) theta (θ) is highly expressed in hematopoietic cells where it participates in immune signaling and platelet function. Mounting evidence suggests that PKCθ may be involved in cancer, particularly blood cancers, breast cancer, and gastrointestinal stromal tumors (GISTs), yet how to target this kinase (as an oncogene or as a tumor suppressor) has not been established. Here, we examine the effect of four cancer-associated mutations, R… Show more
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