Cancer and Trypanosoma cruzi: Tumor induction or protection?

Franco, Pablo Igor Ribeiro; Neto, José Rodrigues do Carmo; Miguel, Marina Pacheco; Machado, Juliana Reis; Celes, Mara Rúbia Nunes

doi:10.1016/j.biochi.2022.10.019

Cited by 2 publications

(1 citation statement)

References 77 publications

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“…Trypanosoma has a strong pathogenicity, and the persistent inflammation caused by its long-term infection can lead to accelerated cell death and regeneration, increased DNA damage and oncogene expression probability, thereby promoting the occurrence of cancer. Its correlation with gastrointestinal, gynecological, and hematological system tumors has been partially confirmed (Ribeiro Franco et al, 2023). Therefore, the toxic attenuation treatment of Trypanosoma is essential for its application in anti-tumor therapy, but unfortunately, there is still insufficient research on toxicity attenuation of T. cruzi, and the side effects or harm of its strains and components on the host cannot be effectively controlled.…”

Section: Anti-tumor Ability Of T Cruzi Componentsmentioning

confidence: 99%

A novel enemy of cancer: recent investigations into protozoan anti-tumor properties

Zheng,

Lu,

Zhou

et al. 2024

Front. Cell. Infect. Microbiol.

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Cancer remains a significant global health issue, despite advances in screening and treatment. While existing tumor treatment protocols such as surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy have proven effective in enhancing the prognosis for some patients, these treatments do not benefit all patients. Consequently, certain types of cancer continue to exhibit a relatively low 5-year survival rate. Therefore, the pursuit of novel tumor intervention strategies may help improve the current effectiveness of tumor treatment. Over the past few decades, numerous species of protozoa and their components have exhibited anti-tumor potential via immune and non-immune mechanisms. This discovery introduces a new research direction for the development of new and effective cancer treatments. Through in vitro experiments and studies involving tumor-bearing mice, the anti-tumor ability of Toxoplasma gondii, Plasmodium, Trypanosoma cruzi, and other protozoa have unveiled diverse mechanisms by which protozoa combat cancer, demonstrating encouraging prospects for their application. In this review, we summarize the anti-tumor ability and anti-tumor mechanisms of various protozoa and explore the potential for their clinical development and application.

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Section: Anti-tumor Ability Of T Cruzi Componentsmentioning

confidence: 99%

A novel enemy of cancer: recent investigations into protozoan anti-tumor properties

Zheng,

Lu,

Zhou

et al. 2024

Front. Cell. Infect. Microbiol.

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How tapeworms interact with cancers: a mini-review

Schreiber,

Vajs,

Horák

2024

PeerJ

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Cancer is one of the leading causes of death, with an estimated 19.3 million new cases and 10 million deaths worldwide in 2020 alone. Approximately 2.2 million cancer cases are attributed to infectious diseases, according to the World Health Organization (WHO). Despite the apparent involvement of some parasitic helminths (especially trematodes) in cancer induction, there are also records of the potential suppressive effects of helminth infections on cancer. Tapeworms such as Echinococcus granulosus, Taenia crassiceps, and more seem to have the potential to suppress malignant cell development, although in a few cases the evidence might be contradictory. Our review aims to summarize known epidemiological data on the cancer-helminth co-occurrence in the human population and the interactions of tapeworms with cancers, i.e., proven or hypothetical effects of tapeworms and their products on cancer cells in vivo (i.e., in experimental animals) or in vitro. The prospect of bioactive tapeworm molecules helping reduce the growth and metastasis of cancer is within the realm of future possibility, although extensive research is yet required due to certain concerns.

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Cancer and Trypanosoma cruzi: Tumor induction or protection?

Cited by 2 publications

References 77 publications

A novel enemy of cancer: recent investigations into protozoan anti-tumor properties

A novel enemy of cancer: recent investigations into protozoan anti-tumor properties

How tapeworms interact with cancers: a mini-review

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