Cancer and Occupational Exposure to Pentachlorophenol and Tetrachlorophenol (Canada)

Abstract

Dermal exposure to pentachlorophenol was associated with non-Hodgkin's lymphoma, multiple myeloma, and kidney cancer, but not with other cancers of a priori interest.

Historical Long-term Exposure to Pentachlorophenol Causing Risk of Cancer - A Community Study

“…Most population-based studies conducted in developed countries used occupational workers as the study population to analysis the relationship between PCP exposure and cancers. The previous case-control studies and recent cohort studies were mainly concerning to lymphoma, and strong evidence had been provided to substantiate the association between exposure to PCP and Non-Hodgkin's lymphoma (Demers et al, 2006). In our study, we also detected the statistical significant SRRs for lymphoma as exposure grade elevated.…”

“…In the large cohort study of Demers et al, 2006, the sawmill workers exposed to PCP with 2-5 exposure years had an increased risk of liver cancer(RR=8. 47,).…”

“…Case reports and case-control studies of hematopoietic cancers published in the 1980s and 1990s indicated the risk of non-Hodgkin lymphoma, soft-tissue sarcoma and multiple myeloma in relation to pentachlorophenol exposure for (Greene et al, 1978;Bishop et al, 1981;Pearce et al, 1986;Smith et al, 1992;Hardell et al, 1994;Hardell et al, 1995;Kogevinas et al, 1995). In the 1990s and 2000s, four cohort studies reported the results between cancer risk and PCP exposure, and most of them reported weak or no risk of exposure to PCP, the authors infer the non-significant results might due to the less study population and healthy worker effects (Hertzman et al, 1997;Demers et al, 2006;Ramlow et al, 1996;Ruder et al, 2011). After it has been forbidden to use in many countries, a worldwide research suggests that in indoor air, bodies of water, and freshwater sediments around the world, PCP levels has declined over time (Zheng et al, 2011).…”

Bioremediation of PCP by Trichoderma and Cunninghamella Strains Isolated from Sawdust

“…PCP is also a possible carcinogen to human (IARC 1999). Dermal exposure to PCP by sawmill workers has been associated with the cases of nonHodgkin's lymphoma, multiple myeloma, kidney cancer and also with a number of physical and neuropsychological health effects in former sawmill workers that persisted long after PCP exposure had ceased (Demers et al 2006;McLean et al 2009). The highest reported usage of PCP is in the wood preserving and treatment industry, where PCP has been widely used to protect the utility poles, cross arms, construction lumber, fence post and many other wood related products from fungal rots, decay and staining by sapstain fungi (Tuomela et al 1999).…”

Follow-up study of cancer incidence after chlorophenol exposure in a community in southern Finland

“…It is noteworthy that dioxins do not penetrate skin easily (11). There was an exposure-response relationship for non-Hodgkin's lymphoma, multiple myeloma, and kidney cancer (10). There was a decreased risk of soft-tissue sarcoma, but the number of cases was low.…”