Cancer and Inflammatory Bowel Disease: Bias, Epidemiology, Surveillance, and Treatment

Solomon, Michael J.; Schnitzler, Margaret

doi:10.1007/s002689900396

Cited by 49 publications

(21 citation statements)

References 69 publications

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“…A meta-analysis looking at the risk of colorectal cancer in patients with UC by decade of disease and defining the risk in pancolitis found a non-significant increase in risk over time [29]. An earlier paper by Solomon and Schnitzler [30]reviewing the same subject in patients with UC concluded that the cancer risk in such patients is increased, particularly if the disease is long-standing or extensive. The risk of cancer begins to increase after the first decade of life by 0.5–1.0% per year.…”

Section: Discussionmentioning

confidence: 99%

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Ulcerative Colitis in Kuwait: A Review of 90 Cases

et al. 2003

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Background: Chronic ulcerative colitis is a disease of unknown etiology. Its incidence is on the rise in various developing countries as has been reported in studies from South-East Asia and the Middle East. There seems to be significant differences in the pattern and the clinical course of this disease in our patient population. The aim of our study is to assess the incidence and the clinical course of the disease in Kuwait. Methods: This is a retrospective study of cases identified over a period of 14 years (1985–1999). Three hundred forty-six patients were identified to have chronic ulcerative colitis. Ninety patients were interviewed for this study. Results: Chronic ulcerative colitis is being identified with increasing frequency. Our local incidence was 2.8 per 100,000 persons per year. The disease was seen in both sexes with equal frequency. It peaks at the third decade of life, with no second peak observed in the sixth decade. The disease was of mild to moderate severity in 93% of the cases. The distribution of the disease in the colon showed pancolitis in 45%, left-sided colitis in 14%, proctosigmoiditis in 21% and proctitis in 20%. Arthritis and arthralgia were the most frequent extraintestinal manifestation seen in 31%. Perianal disease, although rare in ulcerative colitis, was seen in 8%. Of interest is the fact that over 14 years of follow-up, none of our patients developed high-grade dysplasia or colorectal cancer. Four patients required total colectomy mainly due to failure of medical therapy. Conclusions: Chronic ulcerative colitis is occurring with increasing frequency similar to that seen in Western countries. The disease observed in our patient population was of mild to moderate severity, with fewer complications than reported in Western countries. It peaks in the third decade with no second peak. None of our patients developed high-grade dysplasia or colorectal carcinoma.

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Section: Discussionmentioning

confidence: 99%

“…These new modalities will identify those with a high probability of developing colorectal cancer. As gastroenterologists involved in cancer screening in such patients, we have to keep in mind the limitations of colonoscopy in identifying all the early cases [30]. …”

Section: Discussionmentioning

confidence: 99%

Ulcerative Colitis in Kuwait: A Review of 90 Cases

et al. 2003

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“…Indeed, many chronic inflammatory diseases, such as ulcerative colitis, are associated with a high incidence of cancer (54). In addition, blood vessels surrounding human colorectal cancers overexpress NK-1 (55).…”

Section: Discussionmentioning

confidence: 99%

Epidermal Growth Factor Receptor Transactivation Mediates Substance P-induced Mitogenic Responses in U-373 MG Cells

Castagliuolo

Valenick

Liu

et al. 2000

Journal of Biological Chemistry

105

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Ligand-induced activation of G protein-coupled receptors is emerging as an important pathway leading to the activation of certain receptors with intrinsic tyrosine kinase activity, such as the epidermal growth factor receptor (EGFR). Substance P (SP) exerts many effects via activation of its G protein-coupled receptor (neurokinin-1, NK-1). SP participates in acute inflammation and activates key proteins involved in mitogenic pathways, such mitogen-activated protein kinases (MAPKs), stimulating DNA synthesis. We tested the hypothesis that SP-induced MAPK activation and DNA synthesis require activation of the EGFR. In U-373 MG cells, which express functional NK-1, SP induced tyrosine phosphorylation of several proteins including EGFR. SP induced formation of an activated EGFR complex containing the adapter proteins SHC and Grb2, but not c-Src. SP activated the MAPK pathway as shown by increased Erk2 kinase activity. SP induced Erk2 activation, and DNA synthesis was inhibited in cells transfected with a dominant negative EGFR plasmid lacking kinase activity, as well as in cells treated with a specific EGFR inhibitor. In addition, pertussis toxin, an inhibitor of G␣ protein subunits, prevented SP-induced EGFR transactivation and subsequent DNA synthesis. Our results implicate EGFR as an essential regulator in SP/NK-1-induced activation of the MAPK pathway and cell proliferation in U-373 MG cells, and these events are mediated by a pertussis toxin-sensitive G␣ protein. We suggest that this mechanism by which SP controls cell proliferation is an important pathway in tissue restoration and healing.

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“…An increased risk for adenocarcinoma in small bowel Crohn’s disease has been suggested [23, 24, 25, 26]. The possibility for the development of cancer in the afflicted segment with inflammatory tissue left in situ with strictureplasty has been discussed, and some authors suggested consideration of frozen sections intraoperatively in cases with suspect morphologic features [27, 28].…”

Section: Discussionmentioning

confidence: 99%

Quality of Life after Surgical Therapy of Small Bowel Stenosis in Crohn’s Disease

Bröering¹,

Eisenberger²,

Koch³

et al. 2001

Dig Surg

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Background: Improvement in quality of life is one of the important determinants in the treatment of Crohn’s disease. Since there is no cure with radical resection of inflamed bowel, strictureplasty has become a useful surgical technique in the treatment of small bowel obstruction. The scope of this study was to define the results of strictureplasty and resection in terms of quality of life, surgical recurrence and postoperative complications. Methods: The charts of 67 patients with Crohn’s disease of the small bowel were analyzed retrospectively. Patients were treated either by strictureplasty (group A) or resection (group B). Quality of life was evaluated in follow-up examinations using the Inflammatory Bowel Disease Questionnaire (IBDQ). Results: Postoperative morbidity was 14.8% after strictureplasty and 17% after resection (p = 0.8). 50% of the patients treated by strictureplasty and 37% treated by resection developed recurrent disease (p = 0.40). Quality-of-life measurement revealed no significant difference between patients treated by strictureplasty or resection. Conclusion: Results after strictureplasty are comparable to those after resection in terms of complications, recurrence and quality of life in the treatment of small bowel strictures in Crohn’s disease. In the long run there might be an advantage for strictureplasty because it prevents complications caused by resectional therapy such as short bowel syndrome.

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Cancer and Inflammatory Bowel Disease: Bias, Epidemiology, Surveillance, and Treatment

Cited by 49 publications

References 69 publications

Ulcerative Colitis in Kuwait: A Review of 90 Cases

Ulcerative Colitis in Kuwait: A Review of 90 Cases

Epidermal Growth Factor Receptor Transactivation Mediates Substance P-induced Mitogenic Responses in U-373 MG Cells

Quality of Life after Surgical Therapy of Small Bowel Stenosis in Crohn’s Disease

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