Cancer and Coronavirus Disease (COVID-19): Comorbidity, Mechanical Ventilation, and Death Risk

Jarahzadeh, Mohammad Hossein; Asadian, Fatemeh; Farbod, Meraj; Meibodi, Bahare; Abbasi, Hajar; Jafari, Mohammadali; Raee-Ezzabadi, Ali; Bahrami, Reza; Neámatzadeh, Hossein

doi:10.1007/s12029-020-00529-2

Cited by 13 publications

(14 citation statements)

References 39 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Coronavirus disease 2019 (COVID-19) caused by 2019 novel coronavirus (2019-nCoV) has caused significant mortality and has been declared as a global pandemic by the World Health Organization [1][2][3][4][5]. COVID-19 is a major public health concern and one of the leading cause of mortality in most countries [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Proportion and mortality of Iranian diabetes mellitus, chronic kidney disease, hypertension and cardiovascular disease patients with COVID-19: a meta-analysis

Mirjalili

Dastgheib

Shaker

et al. 2021

J Diabetes Metab Disord

Self Cite

View full text Add to dashboard Cite

Background Currently, the number of patients with SARS-COV-2 infection has increased rapidly in Iran, but the risk and mortality of SARS-COV-2 infection in Iranian patients with diabetes mellitus (DM), chronic kidney disease (CKD), hypertension and cardiovascular diseases (CVDs) still not clear. The aim of this meta-analysis was to estimate the proportion and mortality of SARS-COV-2 in these patients. Methods A comprehensive literature search was carried out in PubMed, Web of Sciences, Cochrane Library, EMBASE, CNKI, SciELO, and other databases to identify all relevant studies published up to 10 January, 2020. The proportion and mortality in the patients were assessed by odd ratio (OR) and the corresponding 95 % confidence interval (95 % CI). Results A total of ten case-series including 11,755 cases with SARS-COV-2 infection and 942 deaths were selected. Among them, there were total of 791 DM patients with 186 deaths, 225 CKD patients with 45 deaths, 790 hypertension cases with 86 deaths, and 471 CVDs cases with 60 deaths. Pooled data revealed that the proportion of SARS-COV-2 infection in the patients with hypertension, DM, CVDs and CKD were 21.1 %, 16.3 %, 14.0 % and 5.0 %, respectively. Moreover, the SARS-COV-2 infection were associated with an increased risk of mortality in DM (OR = 0.549, CI 95 % 0.448-0.671, p ≤ 0.001) and CKD (OR = 0.552, 95 % CI 0.367-0.829, p = 0.004) patients, but not hypertension and CVDs. There was no publication bias. Conclusions Our pooled data showed that the proportion of SARS-COV-2 infection was the highest in the Iranian patients with hypertension (21.1 %) followed by DM (16.3 %), CVDs (14.0 %) and CKD (5.0 %). Moreover, DM and CKD in patients with SARS-COV-2 infection were associated with a 0.549 and 0.552-fold increase in mortality, respectively. Clinicians in Iran should be aware of these findings, to identifying patients at higher risk and inform interventions to reduce the risk of death. Moreover, well-designed, large-scale and multicenter studies are needed to improve and validate our findings.

show abstract

Section: Introductionmentioning

confidence: 99%

Proportion and mortality of Iranian diabetes mellitus, chronic kidney disease, hypertension and cardiovascular disease patients with COVID-19: a meta-analysis

Mirjalili

Dastgheib

Shaker

et al. 2021

J Diabetes Metab Disord

Self Cite

View full text Add to dashboard Cite

show abstract

“…Till date, a few studies have explored cancer patients afflicted with COVID-19 [2]. One publication reports 12 cohort studies on cancer patients who tested positive for COVID-19 [1]. Among various other criteria followed here, one important factor was inclusion of clinical studies which reported COVID-19 characteristics including intensive care unit (ICU) admission and mortality.…”

Section: Cancer In Covid-19 Patientsmentioning

confidence: 99%

“…Triaging or prioritizing treatment to patients has become a necessity during the COVID-19 due to limited resources, which significantly affects cancer patients [1,3]. Guidelines are being provided regarding COVID-19's effect on cancers of head and neck, urological tract, breast, and ovaries.…”

Section: Cancer In Covid-19 Patientsmentioning

confidence: 99%

“…One of the major diseases which compromise the immune system of patients is cancer. Although, other non-malignant diseases are reported as common comorbidities for COVID-19, but cancer is strongly implicated with morbidity and mortality in COVID-19 patients [1]. Since cancer patients are immune-compromised, comorbidities like cancers are a major hindrance to COVID-19 treatment because SARS-CoV02 infection highly disrupts the immune system.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cancer and COVID-19: At Perilous Crossroads

Sen¹

2021

COR

View full text Add to dashboard Cite

Cancer has been reported in several COVID-19 patients with varying outcomes. Clinical oncology and COVID-19 treatment are both severely challenged in those patients. Although, cancer was not considered among COVID-19 comorbidities, recent observations bring significant focus to cancer’s role in COVID-19 associated morbidity and mortality. Although the investigations in this direction are less in number, but the results show extremely interesting insights which can better inform the future diagnosis, treatment, and understanding of the pathophysiologies in cancers and COVID-19 in patients. Significant research, therapeutic developments, and treatment procedures need to be invested in this direction. Therefore, some of the current studies exploring this field have been presented in this mini-review.

show abstract

“…It has been reported that the prognosis of the disease is poor in the case of associated comorbidity such as diabetes, 2 hypertension, 3 and malignancy. 4 Oral squamous cell carcinoma (OSCC) is ranked as the 6 th most common malignant worldwide. 5 Although the disease is multifactorial in etiology, tobacco and alcohol have been proposed as the major risk factors.…”

mentioning

confidence: 99%

Oral squamous cell carcinoma, a potential risk factor for SARS-CoV-2 infection and COVID-19 associated complications

Raj¹,

Balaji²,

Varadarajan³

et al. 2020

JOOO

View full text Add to dashboard Cite

Cancer and Coronavirus Disease (COVID-19): Comorbidity, Mechanical Ventilation, and Death Risk

Cited by 13 publications

References 39 publications

Proportion and mortality of Iranian diabetes mellitus, chronic kidney disease, hypertension and cardiovascular disease patients with COVID-19: a meta-analysis

Proportion and mortality of Iranian diabetes mellitus, chronic kidney disease, hypertension and cardiovascular disease patients with COVID-19: a meta-analysis

Cancer and COVID-19: At Perilous Crossroads

Oral squamous cell carcinoma, a potential risk factor for SARS-CoV-2 infection and COVID-19 associated complications

Contact Info

Product

Resources

About