Cancer and Clotting — Trousseau's Warning

Silverstein, Roy L.; Nachman, Ralph L.

doi:10.1056/nejm199210153271611

Cited by 50 publications

(17 citation statements)

References 10 publications

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“…However, the cancers with the increased relative risks in association with venous thrombosis -ovary, prostate, liver, biliary and pancreas -do not prominently share these lifestyle risk factors. On balance, it is most likely that the second cancer was occult and caused the venous thrombosis, conceivably through changes in the clotting pathway (Silverstein and Nachman, 1992;Zacharski et al, 1992). Our study has both strengths and limitations.…”

Section: Discussionmentioning

confidence: 97%

The risk of a second cancer after hospitalisation for venous thromboembolism

et al. 2005

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Although venous thromboembolism (VTE) is common in patients with cancer, it is not known if it is associated with risk of a second malignancy. Using the Danish Cancer Registry and National Registry of Patients, we studied a population-based cohort of 6285 patients with cancer who had an episode of VTE. The risk of a second cancer was compared with that among 30 713 cancer patients without VTE, matched for age, sex, cancer site and year of diagnosis. Overall, the relative risk for a second cancer diagnosis was 1.3 (95% confidence interval (CI) 1.1 -1.4). However, the excess risk varied with the time from the initial cancer diagnosis to the thrombotic event. If the thrombotic episode occurred within the first year, the relative risk for a second cancer was 1.0 (95% CI 0.9 -1.3), but if the VTE occurred more than 1 year after the initial cancer, the overall relative risk for a second cancer was 1.4 (95% CI 1.2 -1.7), with strong associations for cancers of the digestive organs, ovary and prostate. The association between VTE and subsequent incident cancer extends to patients who already have had a cancer diagnosis.

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Section: Discussionmentioning

confidence: 97%

The risk of a second cancer after hospitalisation for venous thromboembolism

et al. 2005

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“…in the absence of obvious risk factors for thrombosis. 100 Several studies have indicated an association between venous thromboembolism and underlying neoplasms, 18,37,69,74,82 but some authors have not found such an association. 41,76 However all previous studies are based on limited material, so their results are not generally applicable.…”

Section: Venous T Hromboembolism As F Irst Manifestation Of C Ancermentioning

confidence: 99%

Coagulation and cancer: Implications for diagnosis and management

Loreto

Martinis

Corsi

et al. 2000

Pathol. Oncol. Res.

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“…9,20,21 Immobilization or local factors such as tumor compression and venous infiltration are important in the pathogenesis of DVT. However, these factors usually indicate locally advanced or disseminated disease that can be difficult to cure.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10][11] The risk of cancer in patients with idiopathic DVT is approximately 10-20%, compared with 6% or less in patients with a wellknown risk factor for DVT. 6,8,9 DVT is classified as idiopathic if no well-known risk factors such as malignancy, surgery, immobilization, or clotting disorders are present. Although some practitioners recommend extensive screening to detect occult malignancy in patients with DVT, [3][4][5][6][7][8][9][10] others propose using only routine clinical examinations, laboratory tests, and chest radiography.…”

mentioning

confidence: 99%