Cancer and Autoimmune Diseases

Giat, Eitan; Ehrenfeld, Michael; Shoenfeld, Yehuda

doi:10.1016/b978-0-12-814307-0.00041-4

Cited by 18 publications

(24 citation statements)

References 103 publications

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“…RA and SLE, are proven to affect patients' risk of cancer. 22 In our LS cohort, an expected increase in mortality due to vulvar cancer was observed. On the contrary, the mortality due to cancers of lung, breast, and cervix were somewhat reduced.…”

Section: Accepted Articlementioning

confidence: 70%

Incidence of lichen sclerosus and subsequent causes of death: a nationwide Finnish register study

Halonen

Jakobsson

Heikinheimo

et al. 2020

BJOG

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Section: Accepted Articlementioning

confidence: 70%

Incidence of lichen sclerosus and subsequent causes of death: a nationwide Finnish register study

Halonen

Jakobsson

Heikinheimo

et al. 2020

BJOG

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“…In patients with autoimmune diseases like pSS, malignancy is one important factor to consider in determining the prognosis of each disease 4,7,33 . We found that the risks of NHL and multiple myeloma increased in patients with pSS.…”

Section: Discussionmentioning

confidence: 86%

“…In previous studies, an increased risk of malignancy in primary SS (pSS) has been reported, most notably, as non-Hodgkin's lymphoma (NHL). 4,[7][8][9][10] However, in a recent systematic review, the increased risk of thyroid cancer in addition to NHL was reported. 11 Some studies included in this meta-analysis revealed a high incidence of several organ-specific malignancies such as thyroid, breast, lung, oral cavity, and stomach cancers in pSS patients;…”

mentioning

confidence: 99%

Risk of malignancy in Korean patients with primary Sjögren's syndrome

Kang

Kim

et al. 2020

Int J of Rheum Dis

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Objectives To evaluate the risks of overall and site‐specific malignancies in Korean patients with primary Sjögren's syndrome (pSS). Methods Using the Korean nationwide healthcare claims database, we constructed a retrospective cohort for prevalent pSS aged over 50 years. After enrollment between January 2012 and December 2014, patients were followed until the development of any malignancy, or until December 2015. Crude incidence rates of malignancies of pSS patients were calculated, and their standardized incidence ratios (SIRs) for malignancies were calculated compared to those in knee osteoarthritis (OA) patients. Results A total of 6,359 pSS and 5,476,302 knee OA patients were included in this study. During follow‐up (19,474 person‐years [PYs]), 310 cases of solid malignancy (158.8/10,000 PYs) and 47 cases of hematologic malignancies (23.5/10,000 PYs) were observed in pSS patients. The risks of overall (SIR 1.30, 95% CI 1.16‐1.43), solid (SIR 1.16, 95% CI 1.03‐1.29), and hematologic malignancies (SIR 4.80, 95% CI 3.43‐6.17) were increased in pSS patients. There was an elevated risk of site‐specific malignancy in non‐Hodgkin's lymphoma (NHL, SIR 6.45, 95% CI 4.05‐8.83), multiple myeloma (SIR 4.88, 95% CI 2.00‐7.76), and oropharynx (SIR 4.16, 95% CI 1.90‐6.42). The risk of lung cancer was increased only in male pSS patients (2.50, 95% CI 1.02‐3.99), while the risk of thyroid cancer was increased in female patients (1.44, 95% CI 1.04, 1.84). Conclusion In patients with pSS over age 50, the risk of solid cancers such as oropharynx, thyroid, and lung cancers is also increased in addition to NHL.

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“…There is increasing awareness of the association between malignant and autoimmune diseases in clinical practice. 6 Cancer may increase the risk of some autoimmune diseases, and patients with autoimmune diseases may be at a higher risk for cancer. 7,8 The mechanism underlying the bidirectional relationship between cancer and autoimmune diseases has yet to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Lung adenocarcinoma and sequential antineutrophil cytoplasmic antibody-associated vasculitis: a case report

Zhang

Miao

et al. 2021

J Int Med Res

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The relationship between antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and lung cancer remains unclear. A 66-year-old man presented with pulmonary nodules. Histological examination of a specimen from computed tomography-guided percutaneous transthoracic biopsy revealed adenocarcinoma. The patient was treated using cryoablation and systemic chemotherapy. Sixteen months later, the patient presented with fever, nasal inflammation, recurrent lung lesions, elevated serum creatinine levels, and high levels of ANCA. Histological examination of a specimen from ultrasound-guided percutaneous renal biopsy revealed pauci-immune necrotizing crescentic glomerulonephritis. The patient responded to treatment, but granulomatosis with polyangiitis recurred and he later died. This case highlights the possibility of sequential AAV with lung cancer. Although this is relatively rare, further research is needed to better understand the association or pathophysiological link between lung cancer and AAV.

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Cancer and Autoimmune Diseases

Cited by 18 publications

References 103 publications

Incidence of lichen sclerosus and subsequent causes of death: a nationwide Finnish register study

Incidence of lichen sclerosus and subsequent causes of death: a nationwide Finnish register study

Risk of malignancy in Korean patients with primary Sjögren's syndrome

Lung adenocarcinoma and sequential antineutrophil cytoplasmic antibody-associated vasculitis: a case report

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