Cancer after repair of esophageal atresia: population-based long-term follow-up

Aspects of esophageal atresia in a population-based setting: incidence, mortality, and cancer risk

“…Moreover, metaplasia in EA patients over 30 years of age seems to be substantially higher, compared to younger EA patients [20]. In a cohort study from Finland, however, no cases of esophageal cancer or cancer of the respiratory tract were identified among 272 EA patients operated on between 1949 and 1978 [21]. Our results support the findings in this study, but there is a need for more research with very long follow-up of large cohorts of EA patients before an association between EA and risk of cancer can be ruled out or established.…”

A patient led, international study of long term outcomes of esophageal atresia: EAT 1

“…Schneider et al went on to endoscope a cohort of adult OA patients and concerningly found that 67% of patients had histological evidence of oesophagitis and 43% Barrett's oesophagus [19]. Several other studies report an increased risk of Barrett's [9,20] in OA and whilst a definitive increased risk of oesophageal cancer in OA patients has yet to be proven [8,21] the frequency of reflux symptoms in this patient group and histological metaplastic changes mean more attention needs to be paid to the consideration of surveillance endoscopy and use of anti-reflux medication in the adult aged OA population.…”

Repaired oesophageal atresia: respiratory morbidity and pulmonary function in adults

“…Findings concerning oesophageal morbidity and function [22], incidence of cancer [23], and natural history of spinal anomalies and scoliosis [24] among adults with repaired OA have already been published. GOR symptoms occurred in 34 of the study participants, and 85 had symptoms of dysphagia due to oesophageal dysmotility after repair of OA; these occurrences were significantly more frequent than among the general population-derived controls [22].…”