Motivated by recent lattice QCD studies, we explore the effects of interactions on strangeness fluctuations in strongly interacting matter at finite temperature. We focus on S-wave Kπ scattering and discuss the role of the K * 0 (800) and K * (1430) resonances within the S-matrix formulation of thermodynamics. Using the empirical Kπ phase shifts as input, we find that the Kπ S-wave interactions provide part of the missing contribution to the strangeness susceptibility. Moreover, it is shown that the simplified treatment of the interactions in this channel, employed in the hadron resonance gas approach, leads to a systematic overestimate of the strangeness fluctuations. In particular, the HRG results for the strangeness and mixed strangeness-baryon number susceptibilities (χ SS and χ BS ) are clearly below those of the lattice, while the results for the thermodynamic pressure and the baryon number susceptibility are in good agreement.This motivates the search for hitherto unknown strange hadrons, which could reduce or eliminate this discrepancy. In the PDG database, there are around twenty unconfirmed states with a mass below 2.0 GeV. Although these are not established resonances, the interactions in the corresponding scattering channels may yield important contribution to thermodynamic quantities.More generally, a possible origin of the discrepancy is interaction strength in channels carrying net strangeness that so far have not been accounted for. Given the corresponding empirical scattering phase shifts, both confirmed and unconfirmed resonances as well as nonresonant interactions can be handled in a unified, modelindependent way, using the S-matrix approach of Ref. [3].The strange scalar channel, with the unconfirmed K * 0 (800) resonance, a.k.a. κ, is a prime candidate. Since the corresponding phase shifts for S-wave Kπ scattering are fairly well determined, this channel is well suited for the S-matrix approach. In addition, the counterpart of κ in the scalar-isoscalar channel, the f 0 (500), a.k.a. σ, though considered to be established [4], is unlike a typical resonance. Since the ππ S-wave phase shifts are known with reasonable accuracy, also this channel is a prime candidate for the S-matrix approach to thermodynamics. In this study we focus on the strange scalar channel and its contribution to strangeness susceptibilities.With the relatively low mass of the interaction strength in the κ channel, it potentially has a large impact on the thermodynamics, in particular on χ SS , owing to the moderate suppression by the Boltzmann factor. In Fig. 1, we illustrate the effect of the κ resonance on pressure and strangeness fluctuation within the HRG approach. For the PDG particle spectrum, we use only confirmed baryons (i.e. three and four star resonances) and established mesons. The contribution of κ to the thermodynamics is approximated by that of an ideal gas of zero-width mesons with mass m κ = 0.682 GeV and degeneracy four. Indeed, the inclusion of this single state improves the HRG result on χ SS dramatica...