Canalicular Obliteration From Toxic Epidermal Necrolysis

Leahey, Alan B.; Wulc, Allan E.; Day, Douglas; Uberti-Benz, Marie; Katowitz, James A.

doi:10.1016/s0002-9394(14)76267-1

Cited by 4 publications

(6 citation statements)

References 3 publications

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“…vitamin A essential for epithelial growth and differentiation); (2) intense in flammation in the acute stage which may alter the ocular surface epithelia [7,9], Conjunctival kysts could sometimes ap pear [8,10].…”

Section: Discussionmentioning

confidence: 99%

“…Conjunctival and palpebral scarring is re sponsible for the loss of the eyelashes, syncchiae, symblepharon, entropion, trichiasis or distichiasis [8,10,11]. Recurrent keratitis can result from the mechanical action of the eyelashes on the cornea [11].…”

Section: Discussionmentioning

confidence: 99%

“…The Sicca syndrome is responsible for a major disruption in corneal hydration [14] with recurrent punctate keratopathy [2,12] and then ulcerations [3,6,10] with an inflam matory response in the anterior chamber. The underlying stroma, sometimes severely thinned [3], could undergo further lysis with descemetocelc and then spontaneous perfor ation [5], This is precisely what occurred with our patient.…”

Section: Discussionmentioning

confidence: 99%

“…Repetitive corneal ulcerations heal slowly. Corneal scars with interstitial vas cularization finally developed resulting in a severe visual impairment [2,5,8,10,12].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to a sicca syndrome, patients could present permanently watery eyes due to cicatricial obliterations of tear points [2,8,10,11]. The severest, but extremely rare, compli cation of TEN is the 'marble eye'.…”

Section: Discussionmentioning

confidence: 99%

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Long-Term Corneal Involvement following Drug-Induced Toxic Epidermal Necrolysis (Lyell’s Disease)

1993

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Toxic epidermal necrolysis is a mucocutaneous disease that also causes important ocular sequelae. Conjunctival retraction, scars and sicca syndrome with severe corneal lesions are the principal ocular complications, sometimes resulting in a major handicap for the patient. We report a case where long-term sequelae ended in corneal perforation requiring a keratoplasty more than 20 years after the initial attack.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Repetitive corneal ulcerations heal slowly. Corneal scars with interstitial vas cularization finally developed resulting in a severe visual impairment [2,5,8,10,12].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Long-Term Corneal Involvement following Drug-Induced Toxic Epidermal Necrolysis (Lyell’s Disease)

1993

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Nasolacrimal duct obstruction after toxic epidermal necrolysis

Burduk¹,

Seredyka-Burduk²,

Kaźmierczak³

et al. 2012

Otolaryngologia Polska

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Toxic epidermal necrolysis also known as Lyell's syndrome is acute dermatomyositis as an adverse drug reactions. It is characterized by erosions of skin over 30% of total body surface area and is associated with significant mortality of 25%-50% of cases. The conjunctival mucosa involvement could result in cornea erosion and ulceration. Other ocular complications are: purulent conjunctivitis with pseudomembrane formation, entropion, symblefaron and synechiae with nasolacrimal duct obstruction or punctual stenosis. The authors present a very rare complication of nasolacrimal duct obstruction after toxic epidermal necrolysis in young girl. The endoscopic dacricystorhinostomy with one lacrimal point intubation was performed. Early ophthalmic assessment and frequent follow-up could be helpful to avoid metaplasia of epithelium, vascular neoplasia in conjunctiva and cornea. This will protect from dysfunction of tears secretion causing nasolacrimal duct or lacrimal point obliteration. If there is a permanent epiphora the endoscopic dacriocystorhinostomy, with silicone tube intubation could be the method of choice. A satisfactory results are also obtained after opening a passage of only one occluded lacrimal point.

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Clinical manifestations and outcomes in 17 cases of Stevens–Johnson syndrome and toxic epidermal necrolysis

1999

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The clinical features and outcomes of 17 patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) were retrospectively reviewed. There were 11 males and six females with an average age of 61.5 years. Ten patients with SJS (seven males, three females) and seven patients with TEN (four males, three females) were identified. Antibiotics, mainly beta-lactams, were the most common cause of SJS/TEN in this series. The mean skin loss in TEN was 45.7% total body surface area in contrast to the lesser skin loss (< 10%) observed in three patients with SJS. Complications included septicaemia, pneumonia and multi-organ failure, mainly in the TEN group. Two patients died from TEN-related complications and one patient with SJS died from unrelated causes. Ocular involvement and skin pigmentary changes represented the most significant long-term sequelae.

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Canalicular Obliteration From Toxic Epidermal Necrolysis

Cited by 4 publications

References 3 publications

Long-Term Corneal Involvement following Drug-Induced Toxic Epidermal Necrolysis (Lyell’s Disease)

Long-Term Corneal Involvement following Drug-Induced Toxic Epidermal Necrolysis (Lyell’s Disease)

Nasolacrimal duct obstruction after toxic epidermal necrolysis

Clinical manifestations and outcomes in 17 cases of Stevens–Johnson syndrome and toxic epidermal necrolysis

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