Canadian Consensus for Treatment of BRAF V600E Mutated Pediatric and AYA Gliomas
Craig Erker,
Magimairajan Issai Vanan,
Valérie Larouche
et al.
Abstract:Background: The treatment of BRAF V600E gliomas with BRAF inhibitors (BRAFis) and MEK inhibitors (MEKis) has been increasingly integrated into clinical practice for pediatric low-grade gliomas (PLGGs) and pediatric high-grade gliomas (HGGs). However, some questions remain unanswered, such as the best time to start targeted therapy, duration of treatment, and discontinuation of therapy. Given that no clinical trial has been able to address these critical questions, we developed a Canadian Consensus statement fo… Show more
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