Canabis-induced Moto-cognitive Dysfunction in Wistar Rats: Ameliorative Efficacy of Nigella Sativa

Abstract

A literature search of related articles was carried out in electronic data sources. Initially, 276 randomised controlled trials related to the title were collected, after which 44 were selected using the keywords. Overlapping articles, articles with a study duration of less than six months, and studies involving young participants were removed from the list. The remaining 20 articles were checked for entitlement using the PEDro scale. A total of nine eligible articles with 1486 participants were analysed. Seven trials used dual-energy x-ray absorptiometry (DXA) to measure bone mineral density (BMD). The six trials published from 2005 to 2013 found a significant increase in BMD. In the remaining one trial, there was no significant increase in BMD. One study published in 2013 reported a significant increase in BMD measured with peripheral qualitative computed tomography, whereas another trial published in 2014 stated that there was a reduction in calcaneal bone density measured by peripheral qualitative ultrasound. From these findings it can be concluded that the whole body vibration machine is a good adjunctive therapy for the prevention and management of osteoporosis in postmenopausal women. However, further investigations are necessary before the same can be recommended for elderly men.

Melatonin salvages lead‐induced neuro‐cognitive shutdown, anxiety, and depressive‐like symptoms via oxido‐inflammatory and cholinergic mechanisms

“…The fixed brain tissues were cleaned in xylene and processed to obtain paraffin wax embedded in paraffin, refrigerated and sectioned into 5‐μm sections of the hippocampal blocks using arotary microtome (MK 1110), and stained with H and E for general cytoarchitecture following the standard protocol for histology (Imam et al., 2016). Thereafter, stained slides were mounted, and histological evaluation was conducted to observe and analyze the degree of neuromorphological distortions in the hippocampal regions of CA1, CA3, and dentate gyrus of rats treated with lead and/or melatonin using a light microscope (Nikon, Tokyo, Japan) at 400× magnification with an in‐built camera attached to a monitor to produce photomicrographs.…”

Chlorpyrifos- and Dichlorvos-Induced Oxidative and Neurogenic Damage Elicits Neuro-Cognitive Deficits and Increases Anxiety-Like Behavior in Wild-Type Rats

“…For analysis, the trial was performed in a well-illuminated wooden box divided into 4 × 4 squares. It has been reported that avoidance of central squares with preference towards the perimeter areas provides an indication of elevated anxiety levels in the rats [30,31,32].…”