Can we use platelet-to-lymphocyte ratio (PLR) to differentiate JAK2-unmutated erythrocytosis from polycythemia vera?

Krečak, Ivan; Lucijanić, Marko

doi:10.1016/j.ejim.2022.09.023

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Recently, there has been growing interest in the diagnostic utility of blood count parameters in patients with erythrocytosis. Some studies have reported that potential of indices such as neutrophil/lymphocyte ratio and platelet/lymphocyte ratio, demonstrating significantly higher values in PV patients compared to those with secondary erythrocytosis [ 29 , 30 ]. We analyzed the differences of these indices between patients with and without reportable mutations.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Approaches to Investigate JAK2-Unmutated Erythrocytosis Based on a Single Tertiary Center Experience

Lee,

Seo,

Kim

et al. 2024

Mol Diagn Ther

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Introduction Erythrocytosis is attributed to various clinical and molecular factors. Many cases of JAK2 -unmutated erythrocytosis remain undiagnosed. We investigated the characteristics and causes of JAK2 -unmutated erythrocytosis. Methods We assessed the clinical and laboratory results of patients with erythrocytosis without JAK2 mutations and performed targeted next-generation sequencing (NGS) panels for somatic and germline mutations. Results In total, 117 patients with JAK2 -unmutated erythrocytosis were included. The median hemoglobin and hematocrit levels were 17.9 g/dL and 53.4%, respectively. Erythropoietin levels were not below the reference range. Thrombotic events were reported in 17 patients (14.5%). Among JAK2 -unmutated patients, 44 had undergone targeted panel sequencing consisting of myeloid neoplasm-related genes, and 16 had one or more reportable variants in ASXL1 (5/44), TET2 , CALR , FLT3 , and SH2B3 (2/44). Additional testing for germline causes revealed eight variants in seven genes in eight patients, including NF1 , BPGM , EPAS1 , PIEZO1 , RHAG , SH2B3 , and VHL genes. One NF1 pathogenic, one BPGM likely pathogenic, and six variants of undetermined significance were detected. Conclusion Somatic and germline mutations were identified in 36.4% and 33.3 % of the JAK2 -unmutated group; most variants had unknown clinical significance. Not all genetic causes have been identified; comprehensive diagnostic approaches are crucial for identifying the cause of erythrocytosis.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Approaches to Investigate JAK2-Unmutated Erythrocytosis Based on a Single Tertiary Center Experience

Lee,

Seo,

Kim

et al. 2024

Mol Diagn Ther

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“…In fact, the EPO levels may be normal in approximately one-third of patients with PV. In particular, obese patients, smokers, and those with chronic obstructive pulmonary disease are at high risk of false negative results [22].…”

Section: Discussionmentioning

confidence: 99%

The Systemic Inflammation Index: A New Candidate Minor Criterion in the Diagnosis of Polycythemia Vera

Gulturk,

Kapucu

2024

JPM

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Aim: To investigate inflammation indices and erythropoietin levels for their potential role in distinguishing polycythemia vera from secondary polycythemia and to compare different parameter combinations in terms of the diagnostic accuracy. Methods: This retrospective cohort was created from patients assessed for polycythemia from January 2020 to December 2023. Polycythemia vera diagnosis was made according to the 2016 World Health Organization criteria (n = 145). Those who did not fulfill the criteria were defined as having secondary polycythemia (n = 84). Results: The neutrophil lymphocyte ratio, platelet lymphocyte ratio and systemic immune-inflammation index were significantly higher in the polycythemia vera group (p < 0.001 for all). Erythropoietin had the highest area under the curve in the analysis to distinguish groups, followed by the systemic immune-inflammation index. The platelet lymphocyte ratio (≥135) had the highest specificity to detect polycythemia vera, followed closely by the systemic immune-inflammation index. The sensitivity for polycythemia vera detection was highest with the erythropoietin and systemic immune-inflammation index combination, followed by erythropoietin and the neutrophil lymphocyte ratio. All the single and combinatory variables exhibited significant performance in predicting polycythemia vera after adjusting for age and sex. However, the erythropoietin and systemic immune-inflammation index combination had the highest odds ratio, followed by erythropoietin alone. Conclusion: These are promising findings supporting the usability of these biomarkers, especially the systemic immune-inflammation index, as minor criteria in the diagnosis of polycythemia vera. It is especially crucial to note that using erythropoietin in combination with these markers may improve diagnostic accuracy.

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Systemic Inflammation Index: A New Candidate Minor Criterion in the Diagnosis of <em>Polycythemia vera</em>

Gulturk,

Kapucu

2024

Preprint

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Aim: To investigate inflammation indices and erythropoietin (EPO) levels for their potential role in distinguishing polycythemia vera (PV) from secondary polycythemia (SP), and to compare different parameter combinations in terms of diagnostic accuracy. Methods: This retrospective cohort was created from patients assessed for polycythemia from January 2020 to December 2023. PV diagnosis was made according to the 2016 WHO criteria (n=145). Those who did not fulfill the criteria were defined as having SP (n=84). Results: NLR, PLR and SII were significantly higher in the PV group (p

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Can we use platelet-to-lymphocyte ratio (PLR) to differentiate JAK2-unmutated erythrocytosis from polycythemia vera?

Cited by 3 publications

References 10 publications

Diagnostic Approaches to Investigate JAK2-Unmutated Erythrocytosis Based on a Single Tertiary Center Experience

Diagnostic Approaches to Investigate JAK2-Unmutated Erythrocytosis Based on a Single Tertiary Center Experience

The Systemic Inflammation Index: A New Candidate Minor Criterion in the Diagnosis of Polycythemia Vera

Systemic Inflammation Index: A New Candidate Minor Criterion in the Diagnosis of <em>Polycythemia vera</em>

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