Can we predict the response to epidermal growth factor receptor targeted therapy?

Abstract

Epidermal growth factor receptor (EGFR) targeted therapy interferes with a molecular pathway that significantly regulates tumor growth, progression, and survival. Several clinical trials on EGFR targeted therapy revealed objective responses, and also improved survival in patients with different solid tumors. However, considerable differences in therapeutic efficacy were recognized across patient populations that might rely on specific character

Eyelashes trichomegaly: An unusual side effect of gefitinib therapy

“…While other common toxicities such as diarrhea or transaminitis may require dose modification or even treatment interruption in severe cases, cutaneous toxicities rarely require and treatment modification. Correlation of occurrence of skin rash with treatment response has been well documented[ 10 ] but whether such hypothesis will prove true with the occurrence of trichomegaly is still not proven. This untoward side effect is usually incidentally diagnosed and patient is asymptomatic with this.…”