Can we identify risk factors during pregnancy for thrombo-embolic events during the puerperium and later in life?

Waldman, Maor; Sergienko, Ruslan; Shoham‐Vardi, Ilana

doi:10.3109/14767058.2014.944155

Cited by 11 publications

(8 citation statements)

References 28 publications

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“…While pregnancy-associated VTE is well characterized, few studies have identified maternal age as a risk factor for VTE in pregnancy. [22][23][24] In the present study AMA was associated with a sixfold increased risk of VTE. The mechanism for this is not well understood but we speculate that the combined effect of pregnancy-induced hypercoagulability and age-associated endothelial damage may play a role in this observation.…”

Section: Discussionsupporting

confidence: 58%

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Risk factors and pregnancy outcome in women aged over 40 years at Korle‐Bu Teaching Hospital in Accra, Ghana

Oppong

Torto

Beyuo

2020

Intl J Gynecology & Obste

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Objective To examine the risk factors and pregnancy outcomes in women aged 40 years and older at the Korle‐Bu Teaching Hospital, Accra, Ghana. Methods A descriptive case–control study comparing women aged 40 years and older at the time of delivery with those between 20 and 34 who delivered at the Korle‐Bu Teaching Hospital between April 1, 2014 and March 31, 2015. Data were collected using interviewer‐administered questionnaires and supplemented with information from patients’ medical records. A multivariate logistic regression was used to estimate the odds ratio and the 95% confidence interval of various risk factors and complications associated with delivery in women aged 40 years or older. Statistical significance was set at P<0.05. Results There were 339 women in the study of which 113 were aged 40 years or older and 226 were aged between 20 and 34 years. Delivery at age 40 years or older was associated with grand multiparity, and unplanned and undesirable pregnancy. There was a higher incidence of gestational diabetes (7.1% vs 2.2%, P=0.036), cesarean delivery (70.1% vs 57.1%, P=0.018), and venous thromboembolism (VTE) (7.1% vs 1.3%, P=0.008) among women older than 40 years. VTE risk was increased sixfold in the women older than 40 years compared with the younger ones. Conclusion Women delivering after age 40 years had a higher incidence of gestational diabetes, cesarean delivery, and VTE compared with younger women. VTE risk increased sixfold in the older women.

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Section: Discussionsupporting

confidence: 58%

“…While pregnancy‐associated VTE is well characterized, few studies have identified maternal age as a risk factor for VTE in pregnancy . In the present study AMA was associated with a sixfold increased risk of VTE.…”

Section: Discussionsupporting

confidence: 47%

Risk factors and pregnancy outcome in women aged over 40 years at Korle‐Bu Teaching Hospital in Accra, Ghana

Oppong

Torto

Beyuo

2020

Intl J Gynecology & Obste

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“…The study concluded that maternal age, obesity, pregnancy-related hypertension, grand multiparity, cesarean delivery, stillbirth and peripartum hysterectomy are independent risk factors responsible for the development of VTE. [ 18 ] A study by Kloviate et al ., compared obese people with normal weighted people to assess the risk of DVT. The study observed that 10-year risk of DVT was high in 35% of the obese people and was only 18% in normal-weight individuals.…”

Section: Discussionmentioning

confidence: 99%

Deep venous thrombosis in a patient undergoing In-vitrofertilization with oocyte donation

et al. 2015

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Deep venous thrombosis (DVT) has been reported extensively following ovarian hyperstimulation syndrome during in-vitro fertilization (IVF). Pregnancy per se increases the risk of DVT due to a hypercoagulable state. The long-term use of hormone replacement therapy (HRT) is another critical factor associated with DVT in women. However, an association between the short-term use of HRT in oocyte donation (OD) cycles and DVT has not yet been reported. We present a case of 43-year-old woman who developed DVT after IVF-OD. DVT was diagnosed at 7 weeks of pregnancy and was managed with low-molecular-weight heparin. We suggest that even a short-term use of HRT should be considered a risk factor for DVT especially in the presence of additional risk factors such as obesity. The patient had an uneventful recovery and delivered three healthy though preterm babies.

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“…A history of stillbirth is associated with a 50% increased odds of composite CVD (OR 1.49 [95% ICI: 1.08–2.06]), 14 a 20% increased probability of CHD (HR 1.18 [95% CI: 1.03–1.37]) 40 and 25% increased probability of CKD (aHR 1.26 [95% CI: 1.09–1.45]) 29 . It confers an almost two‐fold higher probability of future dementia (HR 1.86 [95% CI: 1.28–2.71]) 41 and a 2.5‐fold probability of future VTE (HR 2.56 [95% CI: 1.09–6.05]) 42 . Whether there is a variation in risk depending on the underlying cause has not been explored.…”

Section: Stillbirthmentioning

confidence: 99%

Pregnancy complications and later life women's health

McNestry

Killeen

Crowley

et al. 2023

Acta Obstet Gynecol Scand

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There has been increasing recognition of the association between various pregnancy complications and development of chronic disease in later life. Pregnancy has come to be regarded as a physiological stress test, as the strain it places on a woman's body may reveal underlying predispositions to disease that would otherwise remain hidden for many years. Despite the increasing body of data, there is a lack of awareness among healthcare providers surrounding these risks. We performed a narrative literature review and have summarized the associations between the common pregnancy complications including gestational hypertension, pre-eclampsia, gestational diabetes, placental abruption, spontaneous preterm birth, stillbirth and miscarriage and subsequent development of chronic disease. Hypertensive disorders of pregnancy, spontaneous preterm birth, gestational diabetes, pregnancy loss and placental abruption are all associated with increased risk of various forms of cardiovascular disease.Gestational diabetes, pre-eclampsia, early miscarriage and recurrent miscarriage are associated with increased risk of diabetes mellitus. Pre-eclampsia, stillbirth and recurrent miscarriage are associated with increased risk of venous thromboembolism. Cardiovascular-related morbiditya OR 1.67 (95% ICI: 1.28-2.19) 14 Cerebrovascular morbidity OR 1.83 (95% ICI: 0.79-4.22) 14 Note: Statistics quoted as per reporting study. Abbreviation: OR, odds ratio. a Including coronary artery disease, myocardial infarction, coronary revascularization, peripheral arterial disease, transient ischemic attack, and stroke.

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Can we identify risk factors during pregnancy for thrombo-embolic events during the puerperium and later in life?

Abstract: Maternal age, grandmultiparity, pregnancy-related hypertension, CD, obesity, stillbirth and peripartum hysterectomy are independent risk factors for the development of VTE. CD and blood transfusion were predictive of early versus late VTE.

Cited by 11 publications

References 28 publications

Risk factors and pregnancy outcome in women aged over 40 years at Korle‐Bu Teaching Hospital in Accra, Ghana

Risk factors and pregnancy outcome in women aged over 40 years at Korle‐Bu Teaching Hospital in Accra, Ghana

Deep venous thrombosis in a patient undergoing In-vitrofertilization with oocyte donation

Pregnancy complications and later life women's health

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