Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue?

Byers, Robert M.; El‐Naggar, Adel K.; Lee, Ya Yen; Rao, None Dr. B. Tata; Fornage, Bruno D.; Terry, Nicholas H. A.; Sample, Dory; Hankins, Patti; Smith, Terry L.; Wolf, Pat

doi:10.1002/(sici)1097-0347(199803)20:2<138::aid-hed7>3.0.co;2-3

Cited by 276 publications

(208 citation statements)

References 14 publications

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“…Occult metastasis to neck in our cases was 13.5 % in contrast to conventional SCC cases which shows minimum of 30 % occult metastasis even in early cases [8][9][10].…”

Section: Discussioncontrasting

confidence: 63%

“…VC is associated with recurrence after repeated excision but seldom leads to death unless it dedifferentiates into much poor grade on recurrence. 5 year disease free survival of entire cohort of 101 patients of verrucous carcinoma in study by Rohan R Walvekar et al [14] was 77.6 %, whereas; among conventional SCC, stage I and stage II cancers correspond to similar prognosis [8][9][10].…”

Section: Discussionmentioning

confidence: 97%

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Oral Hybrid Verrucous Carcinoma: A Clinical Study

Gokavarapu

Tantravahi

Gundimeda

et al. 2014

Indian J Surg Oncol

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Hybrid Verrucous Carcinoma is an uncommon tumour wherein Verrucous Carcinoma (VC) is coexisting with conventional Squamous Cell Carcinoma (SCC) within same maternal field. The heterogeneous nature, infrequency of occurrence and the difficulties associated with diagnosis and management of this tumor is discussed through a retrospective study. Patients of primary hybrid VC treated from Jan 2010 to May 2013 at a tertiary institute were analyzed on multivariate cox regression model. During the above mentioned period; 37 patients of hybrid VC were reported; 18(48.6 %) were male and 19(51.3 %) were female. Age ranged between 33 years to 78 years. Median follow up period was 32 months. T stage status and Stage grouping was not statistically significant for mortality (p value: 0.338). In the multivariate cox-regression model, the presence of second primary oral cancer was significantly associated with mortality, adjusted HR; 23.10 (95 % CI: 1.73, 307.65) (p=0.017). Tumour staging is often unreliable in predicting prognosis of hybrid VC, occurrence of second primary oral cancer and recurrence appears to be significant factors effecting prognosis.

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“…Occult metastasis to neck in our cases was 13.5 % in contrast to conventional SCC cases which shows minimum of 30 % occult metastasis even in early cases [8][9][10].…”

Section: Discussioncontrasting

confidence: 63%

Section: Discussionmentioning

confidence: 97%

Oral Hybrid Verrucous Carcinoma: A Clinical Study

Gokavarapu

Tantravahi

Gundimeda

et al. 2014

Indian J Surg Oncol

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“…Researchers have demonstrated that clinical N0 necks have shown occult metastases in about 30% or higher, depending on the size, site of primary tumor and the histological diagnostic methods [21,118]. The great challenge that is being faced by the head and neck oncologists and surgeons is the correct identification of the subset of head and neck cancer patients, of which oral carcinoma constitutes about 30% [90], without micro metastases to the cervical lymph nodes.…”

Section: Justification Of the Studymentioning

confidence: 99%

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

et al. 2011

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“…Byers et al and Sparano et al in their studies described the correlation between increasing tumor size and lymph node metastasis [15,16].…”

Section: Discussionmentioning

confidence: 95%

“…Shear et al in nearly 900 patients found grade and size as predictive factors of lymph node metastasis [14]. Byers et al found that an increasing tumor grade predicted lymph node metastasis (odd ratio2.40) [15]. Sparano et al and Lim et al also showed positive correlation between grade of the tumor and lymph node metastasis [16,17].…”

Section: Discussionmentioning

confidence: 98%

Cervical node metastasis in T1 squamous cell carcinoma of oral tongue- pattern and the predictive factors

Vishak

Rohan

2014

Indian J Surg Oncol

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Background The squamous cell carcinoma (SCC) of the oral tongue is a common cancer in India. Elective lymphadenectomy is generally performed in all patients with T2-T4 tumors. In this study we have tried to analyze the pattern and risk factors associated with lymph node metastasis in T1 tongue cancers. Methods A retrospective review of the records of 57 patients undergoing surgery for treatment of T1 sqamous cell carcinoma of oral tongue was carried out. The clinicopatological features of the tumor, pattern of nodal metastasis and the risk factors associated with lymph node metastasis were studied. Results Totally 57 patients with T1 tumor underwent excision of the primary and modified neck dissection (MND). Lymph node metastasis was found in 36.8 % of the patients. Level I to Level II was the commonest site of metastasis. Skip metastasis at level III and IV was found in 8.5 % of the patients and isolated skip metastasis at level IV in 1.5 % of the patients. The risk factors associated with the lymph node metastasis on univariete analysis were; higher grade, tumor size >1 cm and tumor thickness >3 mm. On multivariate analysis only the tumor thickness was found to be a risk factor for the lymph node metastasis (hazard ratio of 21.59). Conclusions T1 sqamous cell carcinoma of tongue is associated with a high incidence of lymph node metastasis. Elective neck dissection should be considered in all patients with tumors more than 3 mm in thickness

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Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue?

Cited by 276 publications

References 14 publications

Oral Hybrid Verrucous Carcinoma: A Clinical Study

Oral Hybrid Verrucous Carcinoma: A Clinical Study

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

Cervical node metastasis in T1 squamous cell carcinoma of oral tongue- pattern and the predictive factors

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