Can we cure airway hyperresponsiveness with a gym membership?

Chapman, David G.; Berend, Norbert; King, Gregory G.; Salome, Cheryl M.

doi:10.1152/japplphysiol.00582.2010

Cited by 2 publications

(4 citation statements)

References 19 publications

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“…Our hypothesis was confirmed by the finding that a short course of training significantly reduced the airway response to Mch in the absence of deep inspirations in healthy subjects (27). A replicative study on asthmatics population was therefore strongly advocated (5).…”

supporting

confidence: 58%

“…In conclusion, we have found that a 10-wk course of exercise training results in ϳ50% attenuation of AHR in the absence of deep inspirations in untreated mild asthmatics. As stated by Chapman et al (5), reducing airway responsiveness with such a short exercise program provides the potential to dramatically affect the progression of asymptomatic AHR to asthma.…”

Section: Discussionmentioning

confidence: 99%

“…A body of evidence suggests that exercise may positively influence AHR to various extents (9,26,29), suggesting a possible therapeutic role of exercise in asthmatic patients (5). The current prospective "proof of concept" study was designed to test the hypothesis that a short course of intensive physical training may reduce AHR in mild asthma.…”

mentioning

confidence: 99%

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Effects of exercise training on airway closure in asthmatics

Scichilone

Morici

Zangla

et al. 2012

Journal of Applied Physiology

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We previously reported that responsiveness to methacholine (Mch) in the absence of deep inspiration (DI) decreased in healthy subjects after a short course of exercise training. We assessed whether a similar beneficial effect of exercise on airway responsiveness could occur in asthmatics. Nine patients (male/female: 3/6; mean age ± SD: 24 ± 2 yr) with mild untreated asthma [forced expiratory volume in 1 s (FEV(1)): 100 ± 7.4% pred; FEV(1)/vital capacity (VC): 90 ± 6.5%] underwent a series of single-dose Mch bronchoprovocations in the absence of DI in the course of a 10-wk training rowing program (6 h/wk of submaximal and maximal exercise), at baseline (week 0), and at week 5 and 10. The single-dose Mch was established as the dose able to induce ≥ 15% reduction in inspiratory vital capacity (IVC) and was administered to each subject at every challenge occasion. Five asthmatics (male/female: 1/4; mean age ± SD: 26 ± 3 yr) with similar baseline lung function (FEV(1): 102 ± 7.0% predicted; FEV(1)/VC: 83 ± 6.0%; P = 0.57 and P = 0.06, respectively) not participating in the exercise training program served as controls. In the trained group, the Mch-induced reduction in IVC from baseline was 22 ± 10% at week 0, 13 ± 11% at week 5 (P = 0.03), and 11 ± 8% at week 10 (P = 0.028). The Mch-induced reduction in FEV(1) did not change with exercise (P = 0.69). The reduction in responsiveness induced by exercise was of the same magnitude of that previously obtained in healthy subjects (50% with respect to pretraining). Conversely, Mch-induced reduction in IVC in controls remained unchanged after 10 wk (%reduction IVC at baseline: 21 ± 20%; after 10 wk: 29 ± 14%; P = 0.28). This study indicates that a short course of physical training is capable of reducing airway responsiveness in mild asthmatics.

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supporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

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Effects of exercise training on airway closure in asthmatics

Scichilone

Morici

Zangla

et al. 2012

Journal of Applied Physiology

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“…In addition, given the potential to affect the progression of asymptomatic bronchial reactivity to asthma, we could conclude as stated in the editorial from Chapman and colleagues in 2010: "the next time a physician hands an asthmatic patient a prescription and exclaims "take two at a time", the response may be -"do you mean pills or stairs?" (Chapman et al, 2010).…”

Section: Results Of Methacholine Tests In the Absence Of Deep Breathsmentioning

confidence: 99%