Can we apply biomarkers in the management of non-steroidal anti-inflammatory drug exacerbated respiratory disease?
Hyo-In Rhyou,
Young-Hee Nam,
Hae-Sim Park
Abstract:Non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD) is characterized by adult-onset asthma, chronic rhinosinusitis with nasal polyps (CRSwNPs), and aspirin/NSAID hypersensitivity, presenting recurrent asthma exacerbation and poor clinical outcomes. Patients with NERD have heterogeneous clinical phenotypes/endotypes, and the management of NERD remains challenging. Dysregulation of arachidonic acid (AA) metabolism and persistent eosinophilic airway inflammation are the major patho… Show more
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