Can voxel based morphometry, manual segmentation and automated segmentation equally detect hippocampal volume differences in acute depression?

Bergouignan, Loretxu; Chupin, Marie; Czechowska, Yvonne; Kinkingnéhun, Serge; Lemogne, Cédric; Bastard, Guillaume Le; Lepage, Martín; Garnero, Line; Colliot, Olivier; Fossati, Philippe

doi:10.1016/j.neuroimage.2008.11.006

Cited by 250 publications

(183 citation statements)

References 56 publications

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“…FSL-FIRST was shown to provide precise segmentations with high reliability for the hippocampus and has successfully been utilized in MDD studies (Lai and Wu, 2011;Nugent et al, 2012), and using FSL-FIRST allowed displaying not only overall volume information, but also localized differences in shape. Furthermore, we aimed to obtain gray matter information of the hippocampus by the use of VBM, as it represents one of most commonly used instruments in morphometric studies and is highly sensitive for detecting morphometric changes in depression (Bergouignan et al, 2009) and maltreatment alike (Chaney et al, 2014;Dannlowski et al, 2012). Both methods yielded widely identical results.…”

Section: Discussionmentioning

confidence: 99%

“…Although automated segmentation uses pre-defined anatomical landmarks to delineate the hippocampus boundaries in order to obtain volume and shape information, voxel-based morphometry focusses on gray matter structure after segmentation of gray matter across the entire brain and normalization to a template, allowing voxel-wise statistics on the determined gray matter values. Both procedures are highly reliable and sensitive methods for hippocampus morphometry in neuropsychiatric disorders, including MDD (Bergouignan et al, 2009;Lai and Wu, 2011).…”

Section: Image Acquisitionmentioning

confidence: 99%

See 1 more Smart Citation

Hippocampal Atrophy in Major Depression: a Function of Childhood Maltreatment Rather than Diagnosis?

Opel

Redlich

Zwanzger

et al. 2014

Neuropsychopharmacol

169

104

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Reduced hippocampal volumes are probably the most frequently reported structural neuroimaging finding associated with major depressive disorder (MDD). However, it remains unclear whether altered hippocampal structure represents a risk factor for or a consequence of MDD. Reduced hippocampal volumes were consistently reported in subjects affected by childhood maltreatment. As the prevalence of childhood maltreatment is highly elevated in MDD populations, previous morphometric findings regarding hippocampal atrophy in MDD therefore might have been confounded by maltreatment experiences. The aim of this study was to differentiate the impact of childhood maltreatment from the influence of MDD diagnosis on hippocampal morphometry. Depressed patients (85) as well as 85 age-and sex-matched healthy controls underwent structural MRI. The Childhood Trauma Questionnaire was administered to estimate experiences of childhood maltreatment. Hippocampal volume and surface structure was examined by the use of two independent methods, automated segmentation (FSL-FIRST) and voxel-based morphometry (VBM8). In line with existing studies, MDD patients showed reduced hippocampal volumes, and childhood maltreatment was consistently associated with hippocampal volume loss in both, patients and healthy controls. However, no analysis revealed significant morphological differences between patients and controls if maltreatment experience was regressed out. Our results suggest that hippocampal alterations in MDD patients may at least partly be traced back to higher occurrence of early-life adverse experiences. Regarding the strong morphometric impact of childhood maltreatment and its distinctly elevated prevalence in MDD populations, this study provides an alternative explanation for frequently observed limbic structural abnormalities in depressed patients.

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Section: Discussionmentioning

confidence: 99%

Section: Image Acquisitionmentioning

confidence: 99%

Hippocampal Atrophy in Major Depression: a Function of Childhood Maltreatment Rather than Diagnosis?

Opel

Redlich

Zwanzger

et al. 2014

Neuropsychopharmacol

169

104

View full text Add to dashboard Cite

show abstract

“…Similar approaches have been used successfully in previous studies (see for example (Davatzikos et al, 2001). The DARTEL approach for defining ROIs has recently been shown comparable to manual ROI-based analyses for detecting hippocampal volume differences (Bergouignan et al, 2009;Yassa and Stark, 2009). An exploratory voxel-wise analysis surveying the whole cerebrum was conducted to address the possibility that the hippocampal alterations we observed were accompanied by effects elsewhere that were not the focus of the study.…”

Section: Discussionmentioning

confidence: 99%

Hippocampal volume changes in healthy subjects at risk of unipolar depression

Baaré

Vinberg

Knudsen

et al. 2010

Journal of Psychiatric Research

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a b s t r a c tUnipolar depression is moderately heritable. It is unclear whether structural brain changes associated with unipolar depression are present in healthy persons at risk of the disorder. Here we investigated whether a genetic predisposition to unipolar depression is associated with structural brain changes. A priori, hippocampal volume reductions were hypothesized. Using a high-risk study design, magnetic resonance imaging brain scans were obtained from 59 healthy high-risk subjects having a co-twin with unipolar depression, and 53 healthy low-risk subjects without a first-degree family history of major psychiatric disorder. High-risk twins had smaller hippocampal volumes than low-risk twins (p < 0.04). The finding was most pronounced in DZ twins. Groups did not differ on global brain tissue volumes or regional tissue volumes assessed in exploratory voxel-wise whole cerebrum analyses. In conclusion, hippocampal volume reduction may index a predisposition to develop depression and thus may be predictive of future onset of the disorder. Further studies are needed to elucidate the role of (shared) environmental and genetic factors.

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“…Standard VBM analysis however may not be as sensitive to subtle changes in brain morphometry as other methods (Bergouignan et al, 2009;Scanlon et al, 2011). In the current study, using surface based analysis, we localised the largest decrease to the head of the caudate bilaterally, progressing posteriorly along the superior aspect.…”

Section: Sub-cortical Findingsmentioning

confidence: 99%

Cortical thinning and caudate abnormalities in first episode psychosis and their association with clinical outcome

Scanlon

Anderson‐Schmidt

Kilmartin

et al. 2014

Schizophrenia Research

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First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may identify subtle structural changes not appreciated by a measure of volume alone. In this study we adopt complementary methods of assessing the structural integrity of grey matter in FEP patients and assess whether these relate to patient clinical and functional outcome at 3 year follow-up. 1.5 Tesla T1-weighted Magnetic Resonance (MR) images were acquired for 46 patients experiencing their first episode of psychosis and 46 healthy controls. Cerebral cortical thickness and local gyrification index (LGI) were investigated using FreeSurfer software. Volume and shape of the hippocampus, caudate and lateral ventricles were assessed using manual tracing and spherical harmonics applied for shape description. A cluster of cortical thinning was identified in FEP compared to controls; this was located in the right superior temporal gyrus, sulcus, extended into the middle temporal gyrus (lateral temporal cortex -LTC). Bilateral caudate volumes were significantly lower in FEP relative to controls and the right caudate also displayed regions of shape deflation in the FEP group. No significant structural abnormalities were identified in cortical LGI or hippocampal or lateral ventricle volume/shape. Neither LTC nor caudate abnormalities were related to change in symptom severity or global functioning 3 years later. LTC and caudate abnormalities are present at the first episode of psychosis but do not appear to directly affect clinical or functional outcome.

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Can voxel based morphometry, manual segmentation and automated segmentation equally detect hippocampal volume differences in acute depression?

Cited by 250 publications

References 56 publications

Hippocampal Atrophy in Major Depression: a Function of Childhood Maltreatment Rather than Diagnosis?

Hippocampal Atrophy in Major Depression: a Function of Childhood Maltreatment Rather than Diagnosis?

Hippocampal volume changes in healthy subjects at risk of unipolar depression

Cortical thinning and caudate abnormalities in first episode psychosis and their association with clinical outcome

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