Can Vitamin D be a potential treatment for Type 2 diabetes mellitus

Meerza, Dilnasheen; Naseem, Imrana; Ahmed, Jamal Uddin

doi:10.1016/j.dsx.2010.09.001

Cited by 8 publications

(7 citation statements)

References 54 publications

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“…Further, a relationship between vit D and type 2 diabetes and inflammation has been suggested [138]; however, further studies will need to be undertaken and to evaluate in detail the roles and the effect of vit D deficiency, sufficiency and high-dose replacement within the CKD population.…”

Section: Vitamin Dmentioning

confidence: 99%

Exploring metabolic dysfunction in chronic kidney disease

Slee

2012

Nutr Metab (Lond)

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Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and end-stage renal disease (ESRD) is a serious medical condition associated with increased morbidity, mortality, and in particular cardiovascular disease (CVD) risk. CKD is associated with multiple physiological and metabolic disturbances, including hypertension, dyslipidemia and the anorexia-cachexia syndrome which are linked to poor outcomes. Specific hormonal, inflammatory, and nutritional-metabolic factors may play key roles in CKD development and pathogenesis. These include raised proinflammatory cytokines, such as interleukin-1 and −6, tumor necrosis factor, altered hepatic acute phase proteins, including reduced albumin, increased C-reactive protein, and perturbations in normal anabolic hormone responses with reduced growth hormone-insulin-like growth factor-1 axis activity. Others include hyperactivation of the renin-angiotensin aldosterone system (RAAS), with angiotensin II and aldosterone implicated in hypertension and the promotion of insulin resistance, and subsequent pharmacological blockade shown to improve blood pressure, metabolic control and offer reno-protective effects. Abnormal adipocytokine levels including leptin and adiponectin may further promote the insulin resistant, and proinflammatory state in CKD. Ghrelin may be also implicated and controversial studies suggest activities may be reduced in human CKD, and may provide a rationale for administration of acyl-ghrelin. Poor vitamin D status has also been associated with patient outcome and CVD risk and may indicate a role for supplementation. Glucocorticoid activities traditionally known for their involvement in the pathogenesis of a number of disease states are increased and may be implicated in CKD-associated hypertension, insulin resistance, diabetes risk and cachexia, both directly and indirectly through effects on other systems including activation of the mineralcorticoid receptor. Insight into the multiple factors altered in CKD may provide useful information on disease pathogenesis, clinical assessment and treatment rationale such as potential pharmacological, nutritional and exercise therapies.

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Section: Vitamin Dmentioning

confidence: 99%

Exploring metabolic dysfunction in chronic kidney disease

Slee

2012

Nutr Metab (Lond)

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“…Vitamin D 3 (VD 3 ) is produced photochemically in the skin from 7‐dehydrocholesterol, which is produced in relatively large quantities in the skin of most vertebrate animals, including human beings. It is synthesized in the skin after exposure to ultraviolet B light and also by intake of a wide variety of foods . VD 3 appears to be involved in the amelioration of glycaemic conditions in diabetic rats induced with streptozotocin (STZ) and in the improvement of cognition through synaptic plasticity and by increasing choline acetyltransferase activity, whose function is to synthesize acetylcholine (ACh).…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin D₃on behavioural and biochemical parameters in diabetes type 1‐induced rats

Calgaroto

Thomé

Costa

et al. 2014

Cell Biochemistry & Function

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Diabetes is associated with long-term complications in the brain and reduced cognitive ability. Vitamin D3 (VD3 ) appears to be involved in the amelioration of hyperglycaemia in streptozotocin (STZ)-induced diabetic rats. Our aim was to analyse the potential of VD3 in avoiding brain damage through evaluation of acetylcholinesterase (AChE), Na(+) K(+) -adenosine triphosphatase (ATPase) and delta aminolevulinate dehydratase (δ-ALA-D) activities and thiobarbituric acid reactive substance (TBARS) levels from cerebral cortex, as well as memory in STZ-induced diabetic rats. Animals were divided into eight groups (n = 5): control/saline, control/metformin (Metf), control/VD3 , control/Metf + VD3 , diabetic/saline, diabetic/Metf, diabetic/VD3 and diabetic/Metf + VD3 . Thirty days after treatment, animals were submitted to contextual fear-conditioning and open-field behavioural tests, after which they were sacrificed and the cerebral cortex was dissected. Our results demonstrate a significant memory deficit, an increase in AChE activity and TBARS levels and a decrease in δ-ALA-D and Na(+) K(+) -ATPase activities in diabetic rats when compared with the controls. Treatment of diabetic rats with Metf and VD3 prevented the increase in AChE activity when compared with the diabetic/saline group. In treated diabetic rats, the decrease in Na(+) K(+) -ATPase was reverted when compared with non-treated rats, but the increase in δ-ALA-D activity was not. VD3 prevented diabetes-induced TBARS level and improved memory. Our results show that VD3 can avoid cognitive deficit through prevention of changes in important enzymes such as Na(+) K(+) -ATPase and AChE in cerebral cortex in type 1 diabetic rats.

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“…However, the present study showed no association between serum vitamin D levels and dietary intake of vitamin D. This result is expected because there are limited foods that naturally contain vitamin D, and almost all foods have less than 400 IU of vitamin D per 100 g edible portion. The best sources of vitamin D are oily fish, cod liver oil, beef liver and egg yolk (31). Alternatively, during sunlight exposure, ultraviolet (UV) photons are absorbed by the epidermal and dermal cells and produce vitamin D3 from its pre-vitamin (32).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Trends of Vitamin D Deficiency among Iranian Adults: A Longitudinal Study from 2001-2013

Khosravi-Boroujeni

Sarrafzadegan

Sadeghi³

et al. 2017

J Nutr Sci Vitaminol

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Summary Vitamin D deficiency/insufficiency is currently considered to be a re-emerging public health problem globally. This study was designed to determine the prevalence of vitamin D deficiency and insufficiency and to investigate its trend from 2001 to 2013 in a longitudinal study of Iranian adults. This study was part of a population-based, longitudinal ongoing study of Iranian healthy adults aged 35 y and older at baseline. Serum vitamin D level was assessed in a sub-sample of 370 subjects, who were apparently healthy at the time of recruitment in 2001 and were free from MetS, in three phases (2001, 2007 and 2013) during the 12-y study period. Adjusted prevalence and trend of vitamin D deficiency were calculated. Mean serum vitamin D levels increased over the time of the study (52.12, 54.27 and 62.28 nmol/L, respectively) and the prevalence of vitamin D deficiency decreased Vitamin D has long been recognized for its role in the regulation of calcium and phosphorus homeostasis and bone health (4). Moreover, there is also an increasing body of evidence that has found an association between vitamin D deficiency and other health problems (5). For example, the risk of all-cause and cardiovascular mortality was reported higher in people with a lower level of serum 25(OH)D (6-8). Although the optimal serum level of 25(OH)D in humans is not fully recognised, several expert groups have considered levels of less than 25 nmol/L to be a 'deficiency' and 25-50 nmol/L to be an 'insufficiency' (9, 10).Due to the potential health problems related to vitamin D deficiency and its increasing prevalence, vitamin D deficiency/insufficiency is currently recognized as a reemerging public health problem at the global level (11). It is estimated that more than one billion people are vitamin D deficient/insufficient (12). For example, the prevalence of vitamin D deficiency was 36% in young adults in the United States (13), while studies in Australia have also reported a high prevalence of vitamin D deficiency (33% and 40% in men and women respectively), despite the high levels of sunshine (14). However, the situation seems to be worse in Middle-Eastern countries, despite the sunny climate throughout the year (15). The prevalence of vitamin D deficiency/insufficiency in adults was reported as 61.4% and 87.8% in Kuwait and Saudi Arabia respectively (16,17). Although there is no national level data on vitamin D deficiency in Iran, several small scale studies reported a prevalence of 44.2% to 72.3% in adults (18,19). Further, there are few longitudinal studies which have investigated the trends in the prevalence of vitamin D deficiency (20). Given the importance of adequate 25(OH)D levels and chronic disease prevention, this study aimed to determine the current prevalence of vitamin D deficiency and insufficiency,

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Can Vitamin D be a potential treatment for Type 2 diabetes mellitus

Cited by 8 publications

References 54 publications

Exploring metabolic dysfunction in chronic kidney disease

Exploring metabolic dysfunction in chronic kidney disease

Effect of vitamin D₃on behavioural and biochemical parameters in diabetes type 1‐induced rats

Prevalence and Trends of Vitamin D Deficiency among Iranian Adults: A Longitudinal Study from 2001-2013

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Can Vitamin D be a potential treatment for Type 2 diabetes mellitus

Cited by 8 publications

References 54 publications

Exploring metabolic dysfunction in chronic kidney disease

Exploring metabolic dysfunction in chronic kidney disease

Effect of vitamin D3on behavioural and biochemical parameters in diabetes type 1‐induced rats

Prevalence and Trends of Vitamin D Deficiency among Iranian Adults: A Longitudinal Study from 2001-2013

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Effect of vitamin D₃on behavioural and biochemical parameters in diabetes type 1‐induced rats