Can Vestibular Stimulation be Used to Treat Obesity?

McGeoch, Paul D.

doi:10.1002/bies.201800197

Cited by 8 publications

(2 citation statements)

References 72 publications

(181 reference statements)

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“…Collectively, the present results suggest that the vestibular system dysregulation influences body fat elevated by HSHFD in mice. Homeostasis is maintained in physiological and pathological states through the optimal use of energy regulated by various organs, such as the nervous system [31,32]. The vestibular system may be related to the centers that integrate multiple inputs for the regulation of a set-point for body fat.…”

Section: Discussionmentioning

confidence: 99%

Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice

Kawao¹,

Takafuji²,

Ishida³

et al. 2020

PLoS ONE

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The vestibular system controls balance, posture, blood pressure, and gaze. However, the roles of the vestibular system in energy and glucose metabolism remain unknown. We herein examined the roles of the vestibular system in obesity and impaired glucose metabolism using mice with vestibular lesions (VL) fed a high-sucrose/high-fat diet (HSHFD). VL was induced by surgery or arsenic. VL significantly suppressed body fat enhanced by HSHFD in mice. Glucose intolerance was improved by VL in mice fed HSHFD. VL blunted the levels of adipogenic factors and pro-inflammatory adipokines elevated by HSHFD in the epididymal white adipose tissue of mice. A β-blocker antagonized body fat and glucose intolerance enhanced by HSHFD in mice. The results of an RNA sequencing analysis showed that HSHFD induced alterations in genes, such as insulin-like growth factor-2 and glial fibrillary acidic protein, in the vestibular nuclei of mice through the vestibular system. In conclusion, we herein demonstrated that the dysregulation of the vestibular system influences an obese state and impaired glucose metabolism induced by HSHFD in mice. The vestibular system may contribute to the regulation of set points under excess energy conditions. OPEN ACCESS Citation: Kawao N, Takafuji Y, Ishida M, Okumoto K, Morita H, Muratani M, et al. (2020) Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice. PLoS ONE 15 (2): e0228685. https://doi.org/10.sympathetic nervous system in rodents [4,5]. Luxa et al. reported that labyrinthectomy increased myofiber remodeling in the soleus muscle of mice [6]. We recently revealed that gravity changes affect muscle and bone through the vestibular system in mice [7,8]. Collectively, these findings suggest that the vestibular system regulates the musculoskeletal system partly through the sympathetic nervous system. Dysfunctions in the vestibular system clinically cause dizziness, vertigo, and unsteadiness [9]. Long-term space flight impairs the vestibular system in astronauts who experience orthostatic intolerance and unsteadiness [3]. However, the roles of the vestibular system in metabolic homeostasis have not yet been elucidated in detail.Excess energy is stored in white adipose tissue (WAT) as lipids and causes obesity, a risk factor for diabetes [10]. Adipocytes differentiate from mesenchymal stem cells, and the activation of adipogenic differentiation is followed by enhanced levels of peroxisome proliferatoractivated receptor γ (PPARγ), aP2, long chain acyl-CoA synthetase (ACSL) 1, and lipoprotein lipase (LPL). In obesity, WAT releases pro-inflammatory adipokines, such as tumor necrosis factor (TNF)-α, plasminogen activator inhibitor (PAI)-1, and monocyte chemoattractant protein (MCP)-1, which impair glucose metabolism due to the induction of low-grade systemic inflammation [10]. Adiponectin and leptin released from adipose tissue exert pleiotropic effects in glucose metabolism [10]. Circulating adiponectin and leptin produced from WAT are negatively and positively r...

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Section: Discussionmentioning

confidence: 99%

Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice

Kawao¹,

Takafuji²,

Ishida³

et al. 2020

PLoS ONE

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“…6 Vestibular dysregulation was reported to influence obesity and vestibular stimulation was reported to alter the set point of fat. 7,8 Although there are multiple methods available to stimulate the vestibular system, optimal stimulation is required to avail maximum beneficial effects. Electrical vestibular stimulation is a simple and non-invasive method and can control the strength of the stimulation offered.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of 12 weeks of electrical vestibular nerve stimulation in the management of obesity: A pilot study

Sailesh

Bhise

Parapurath³

et al. 2022

Asian J Med Sci

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Background: It was hypothesized that electrical vestibular nerve stimulation (VeNs) was an effective therapy in the management of obesity. Aims and Objectives: The present pilot study was undertaken to observe the efficacy of 12-week electrical VeNs in the management of obesity. Materials and Methods: As this is a pilot study, a total of ten obese male and female participants were recruited after obtaining written, informed consent. After recording the baseline values, electrical VeNs was administered as an intervention for 12 weeks. The post-interventional assessment was done after 12 weeks. Results: There was a significant decrease in the serum cholesterol, VLDL, and HbA1C followed by the vestibular stimulation for 12 weeks. Although the body weight was decreased, it was not statistically significant. Conclusion: The present pilot study results support the positive impact of electrical VeNs in the management of obesity. Further, detailed studies with higher sample size were recommended to provide adequate scientific evidence to adopt electrical VeNs as an alternative therapy for the management of obesity.

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Changes in body composition in unilateral vestibular hypofunction: relationships between bioelectrical impedance analysis and neuro-otological parameters

Micarelli

Viziano

Granito³

et al. 2021

Eur Arch Otorhinolaryngol

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Can Vestibular Stimulation be Used to Treat Obesity?

Cited by 8 publications

References 72 publications

Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice

Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice

Effectiveness of 12 weeks of electrical vestibular nerve stimulation in the management of obesity: A pilot study

Changes in body composition in unilateral vestibular hypofunction: relationships between bioelectrical impedance analysis and neuro-otological parameters

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