Can Vascular Headaches Be Triggered by the Autonomic Nervous System?

Aubineau, P.; Mathiau, P.

doi:10.1007/978-1-4612-0303-2_34

Cited by 2 publications

(4 citation statements)

References 33 publications

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“…Hence, ir cannot be excluded that this drug had also acted as MAO-A inhibitor under the present experimental conditions. The lack of MAO-B activity related to nerve fibers in major cerebral arteries has been used as evidence against the existence of a serotonergic innervation impinging on them (2). However, the presence of MAO-B does not rule out that of MAO-A.…”

Section: Discussionmentioning

confidence: 99%

“…According to these results MAO-A should be located in sympathetic fibers and MAO-B in Schwann cells. The absence of MAO-B activity related to nerve fibers in major cerebral arteries has been used asa ground to deny that they may receive serotonergic innervation (2). However, it should be taking into account that those data were produced by assaying MAO activity with an external substrate different from 5-HT which does not rule out the existence of MAO degrading 5-HT in brain base arterles.…”

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confidence: 99%

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MAO activity in serotonergic endings of rat major cerebral arteries

Pablo

Ajubita

Criado

et al. 2004

J. Physiol. Biochem.

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The present work studies the existence of monoamine oxidase (MAO) activity in serotonergic endings present in rat major cerebral arteries. Enzymatic activity was appraised in vivo by serotonin (5-HT) accumulation or 5-hydroxyindole acetic acid (5-HIAA) disappearance with time after systemic administration of MAO inhibitors. Pargyline (75 mg/Kg, ip) brought about significant 5-HT increase and 5-HIAA decrease in major cerebral arteries 30 and 60 min after its administration. Clorgyline (75 mg/Kg, ip) also induced 5-HT enhancement and 5-HIAA decline in these arteries 30 and 60 min after its injection. However, treatment with deprenyl (75 mg/Kg, ip) only evoked a significant 5-HT increase at 60 min. When either clorgyline (5 mg/Kg, ip) or deprenyl (5 mg/Kg, ip) were administered 5-HT and 5-HIAA levels remained unaffected. Two weeks after performing electrolytical lesion of dorsal raphe nucleus and 60 min after clorgyline (75 mg/Kg, ip) injection 5-HT and 5-HIAA levels appeared significantly reduced in cerebral arteries and striatum when compared to sham-lesioned controls. These results suggest that MAO-A isoform acting on endogenous 5-HT is present in rat major cerebral arteries and is located in nerve endings of fibers arising from dorsal raphe nucleus.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

MAO activity in serotonergic endings of rat major cerebral arteries

Pablo

Ajubita

Criado

et al. 2004

J. Physiol. Biochem.

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“…For example, cerebrovascular nerves exert a trophic influence on the arteries, especially during development (23). Furthermore, these nerves are ascribed a role in vascular pain syndromes (24,25).…”

Section: Figure 1 Classification Of Cerebrovascular Nerves the Intrmentioning

confidence: 99%

“…Also, the explanation of the symptoms of clinical syndromes that are linked with the cavernous sinus, e.g. cluster headache (25,37), will have a more solid basis.…”

Section: The Cavernous Sinus and Pathways For Cerebrovascular Nervesmentioning

confidence: 99%

Pathways and nerve densities in cerebrovascular innervation

Bleys

Groen

1995

Biomedical Reviews

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• // is gradually becoming clear that cerebrovascular nerves contribute to the control of the cerebral circulation although the knowledge of the functional mechanisms is far from complete. However, many aspects of the morphologic substrate have been identified. The basal cerebral arteries receive sympathetic, parasympathetic and sensory innervation, utilizing the superior cervical and stellate, the pterygopalatine and otic, and the trigeminal ganglia, respectively, as the main peripheral sources. Many of the neural pathways to the cerebral arteries have been elucidated. Those to the supratentorial arterial tree are distributed via the cavernous sinus and surrounding regions. Not only the "classical" neurotransmitters, but also many neuropeptides are found in cerebrovascular nerves. This will lead to new insights since the concepts of cotransmission and neuromodulation have been established now. In the arterial wall, a multilayered organization of nerves has been recognized, consisting ofparavascular nerve bundles of passage, a superficial plexus and a terminal plexus located at the adventitial-medial border. Human basal cerebral arteries display a topographical heterogeneity of densities of terminal nerve plexuses. Highest nerve densities are found in arterial segments forming the circle of Willis, in the efferent part of the posterior cerebral artery and in the anterior choroidal artery. Nerve density appears to be determined by locality rather than vascular diameter. Furthermore, local decreases in nerve density are observed with ageing and disease in animals and humans. • The existence of nerves around and in the walls of cerebral arteries has been known for a long time. Already in 1664 Sir Thomas Willis described in humans minute nerves on the arteries of the circle now bearing his name (1). However, there has been a controversy about their role (2), which was often considered of little importance. Cerebrovascular innervation has received more attention over the last few decades and the development of techniques such as immunohistochemistry and antero-and retrograde neuronal tracing led to a rapid increase of knowledge in this field. Nerves in the walls of the major cerebral arteries have been demonstrated in many species, including human (3), monkey (4), rabbit (5), rat (6), mouse (5), cat (7), dog (8), bullfrog (9) and bat (10). These perivascular nerves have been classified as sympathetic, parasympathetic and sensory, each group characterized by particular neurotransmitters (11). The aforementioned subpopulations of nerves constitute the so-called extrinsic system of cerebrovascular innervation which utilizes peripheral sources, i.e. sympathetic, parasympathetic and sensory ganglia (Fig. 1). There are also reports on an intrinsic system consisting of direct connections between central origins, like locus coeruleus and nucleus tractus solitarii, and intraparenchymal arteries (12,13). Knowledge of the function of cerebrovascular nerves is still far from complete. It is generally assumed that they play some r...

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Can Vascular Headaches Be Triggered by the Autonomic Nervous System?

Cited by 2 publications

References 33 publications

MAO activity in serotonergic endings of rat major cerebral arteries

MAO activity in serotonergic endings of rat major cerebral arteries

Pathways and nerve densities in cerebrovascular innervation

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