Can urinary nerve growth factor and bladder wall thickness correlation in children have a potential role to predict the outcome of non-monosymptomatic nocturnal enuresis?

Telli, Onur; Samancı, Cesur; Sarıcı, Haşmet; Hasçiçek, Ahmet Metin; Kabar, Mucahit; Eroğlu, Muzaffer

doi:10.1016/j.jpurol.2015.03.018

Cited by 12 publications

(25 citation statements)

References 21 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, more cases need to be enrolled for more accurate evaluation of the usefulness of urinary NGF and BDNF. Second, MVV in the present study was lower than in a previous study, which reported that urinary levels of NGF were higher in children with NMNE, not with MNE . The functional bladder capacity is small in Japanese children compared with that in Western children .…”

Section: Discussioncontrasting

confidence: 84%

“…Second, MVV in the present study was lower than in a previous study, which reported that urinary levels of NGF were higher in children with NMNE, not with MNE. 8 The functional bladder capacity is small in Japanese children compared with that in Western children. 24 Additionally, in some of our patients with MNE, OAB, or dysfunctional voiding could be overlooked because of an inappropriate bladder diary or F I G U R E 2 Survival function estimates for night-time wetting show cure rates at the end of treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Responses were defined according to the ICCS standardization guidelines as follows: complete response (CR) as a 100% decrease, partial response (PR) as a 50% to 99% decrease, and nonresponse (NR) as a 0% to 49% decrease in the number of wet nights. The following baseline parameters were obtained: the maximum voided volume (MVV) determined using a voiding diary, first morning Age, y (IQR) 9 (8-11) 10 (8)(9)(10)(11)(12) .49 9 (7-11) 9 (8)(9)(10)(11) .74…”

Section: Patients and Data Collectionmentioning

confidence: 99%

“…Experimental and clinical evidence suggest a role for neurotrophic factors in the bladder and the micturition pathway in the pathology of MNE. In particular, recent studies have proposed urinary nerve growth factor (NGF) and brain‐derived neurotrophic factor (BDNF) as candidate diagnostic biomarkers for adult overactive bladder syndrome (OAB), and as potential biomarkers in children with OAB or NMNE . In this study, we measured urinary NGF and BDNF in children with MNE and healthy controls, and evaluated the relationships of these factors with MNE as candidate predictors for treatment outcomes.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Urinary nerve growth factor can predict therapeutic efficacy in children with monosymptomatic nocturnal enuresis

Morizawa

Aoki

Iemura

et al. 2019

Neurourology and Urodynamics

View full text Add to dashboard Cite

Aim To determine the urinary levels of nerve growth factor (NGF) and brain‐derived neurotrophic factor (BDNF) in children with monosymptomatic nocturnal enuresis (MNE) and evaluate whether these factors can be used as biomarkers for the treatment outcome. Methods NGF and BDNF levels were measured and compared in 38 children (28 boys and 10 girls) with MNE and 25 children (18 boys and 7 girls) with no urinary symptoms were assessed. The mean ages in the patient and control groups were 9 and 10 years, respectively (P = .49). The patients were treated with either alarm or desmopressin therapy. Results The urinary NGF/creatinine and BDNF/creatinine ratios were significantly higher in the patient group than in the control group (P = .0003 and P = .0095, respectively). NGF and BDNF levels showed a significant positive correlation (P = .0020, r = 0.40). With respect to the degree of response, 19 patients (50%) showed complete response (CR) or partial response (PR), and 19 patients (50%) showed nonresponse (NR). The urinary NGF/creatinine and BDNF/creatinine ratios were significantly higher in the NR group than in the CR and PR groups (P = .0003 and P = .0003, respectively). Conclusions Urinary NGF/creatinine and BDNF/creatinine ratios were significantly higher in children with MNE than in healthy controls. Urinary NGF/creatinine can be predictive factors of a poor treatment outcome in children with MNE.

show abstract

Section: Discussioncontrasting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Patients and Data Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Urinary nerve growth factor can predict therapeutic efficacy in children with monosymptomatic nocturnal enuresis

Morizawa

Aoki

Iemura

et al. 2019

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

“…Primary NE may be either monosymptomatic nocturnal enuresis (MNE) with normal daytime voiding patterns or non-monosymptomatic NE caused by overactive bladder and presented by daytime wetting, urinary frequency, urgency, hesitancy and interrupted stream with variable-sized wet patches, repeated lower urinary or genital pain, and awakening after wetting (Khedr et al 2015;Telli et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Primary monosymptomatic nocturnal enuresis: an etiological study

Bahnasy

El-Heneedy

El-Seidy

et al. 2018

Egypt J Neurol Psychiatry Neurosurg

View full text Add to dashboard Cite

Background: Nocturnal enuresis (NE) is a very common chronic pediatric problem with bad psychological consequences. Methods: Forty primary monosymptomatic nocturnal enuresis (MNE) children and 20 healthy controls were recruited in the study and subjected to history taking, neurological and urological examinations, and psychological assessment using the Arabic-translated and validated version of child behavior checklist, sleep architecture studying through onenight polysomnography (PSG), and vasopressin levels determination both diurnal and nocturnal. Results: Enuretic children had positive family history of NE in 42.5%, inverted vasopressin circadian rhythm in 52.5% and PSG changes in the form of increased N3 deep sleep % of total sleep time (TST), sleep stage transition index (SSTI), periodic limb movement index (PLMI), and snore index. Enuretic children PSG showed decreased deep sleep latency, N1% of TST, N2% of TST, and REM % of TST. The child behavior checklist showed higher anxious depressed symptoms, social problem, attention problems, and internalizing problems in enuretic children than control subjects. Conclusions: MNE is a heterogeneous disorder with multiple factors interplay in its pathogenesis. So, the management must be tailored patient by patient according to the dominating etiology.

show abstract

Urinary biomarkers in children with neurogenic and non‐neurogenic lower urinary tract dysfunction: A systematic review and meta‐analysis

Sekerci,

Yucel,

Tarcan

2024

Neurourology and Urodynamics

View full text Add to dashboard Cite

AimThe aim of this systematic review is to assess urinary biomarkers studied in children with neurogenic and non‐neurogenic lower urinary tract dysfunction (LUTD).Materials and MethodsThe systematic review was conducted in accordance with the PRISMA guidelines. The screening was performed on PUBMED without any publication date limitation. Only original articles were included. Parameters related to the following topics were obtained: study design, characteristics of participants, number of participants, age, control group, types of biomarkers, measurement technique in urine, subgroup analysis, urodynamic findings, and outcome. Dutch Cochrane Checklist (DCC) and level of evidence by EBRO platform were used for quality assessment. Meta‐analysis was performed with the Comprehensive Meta‐Analysis Version 4 program.ResultsA total of 494 studies were screened and 16 studies were included. 11 (68.75%) were conducted in children with non‐neurogenic LUTD and 5 (31.25%) neurogenic LUTD. Nerve growth factor (NGF) was evaluated in 12 studies, brain‐derived neurotrophic factor (BDNF) in 5, Tissue Inhibitor of Metalloproteinase‐2 (TIMP‐2) in 2, transforming growth factor beta‐1 (TGF Beta‐1) in 2, neutrophil gelatinase‐associated lipocalin (NGAL) in 1, and Aquaporin‐2 in 1. According to DCC, 10 (62.5%) articles were evaluated on 4 (37.5%) items and 4 articles on 5 items. The average score was 3.91+/−0.56. The level of evidence was found as B for 13 (81.25%) articles and C for 3 (18.75%). In meta‐analysis, urinary NGF levels in children with non‐neurogenic LUTS were significantly higher than in the healthy control group (Hedges's g = 1.867, standard error = 0.344, variance = 0.119, p = 0.0001).ConclusionUrinary biomarkers are promising for the future with their noninvasive features. However, prospective studies with larger sample sizes are needed to better understand the potential of urinary biomarkers to reflect urodynamic and clinical findings in children with LUTD.

show abstract

Can urinary nerve growth factor and bladder wall thickness correlation in children have a potential role to predict the outcome of non-monosymptomatic nocturnal enuresis?

Cited by 12 publications

References 21 publications

Urinary nerve growth factor can predict therapeutic efficacy in children with monosymptomatic nocturnal enuresis

Urinary nerve growth factor can predict therapeutic efficacy in children with monosymptomatic nocturnal enuresis

Primary monosymptomatic nocturnal enuresis: an etiological study

Urinary biomarkers in children with neurogenic and non‐neurogenic lower urinary tract dysfunction: A systematic review and meta‐analysis

Contact Info

Product

Resources

About