Can urinary excretion rate of malondialdehyde, uric acid and protein predict the severity and impending death in perinatal asphyxia?

Banupriya, C.; Ratnakar,; Peroumal, Doureradjou; Mondal, Nivedita; Bhat, Vishnu; Koner, Bidhan Chandra

doi:10.1016/j.clinbiochem.2008.04.011

Cited by 29 publications

(24 citation statements)

References 30 publications

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“…13 Present study also supported by study done by Kumar et al which show that urinary UA/CR ratio was higher in the asphyxiated group compared to controls. 14 In study by Bahubali et al found that urinary UA/CR ratio was higher in the asphyxiated group compared to controls, they also reported a significant negative correlation between this ratio and the APGAR score.15 Similar results are given by studies done by Banupriya, Bhongir and Nariman S. 16,17,18 In present study also, we found a significant negative linear correlation between urinary UA/CR ratio and the APGAR score.…”

supporting

confidence: 80%

Study of urinary uric acid to creatinine ratio as a biochemical marker of perinatal asphyxia and its correlation with Apgar Score

Sreekrishna

Eregowda

Sharma

2018

Int J Contemp Pediatr

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Background: Perinatal asphyxia is a common neonatal problem and contributes significantly to neonatal morbidity and mortality. Every hour, 104 children die as a result of asphyxia. In India; between 250,000 to 350,000 infants die each year secondary to birth asphyxia and mostly within the first three days of life. The present study was performed to determine the Urinary Uric Acid to Creatinine Ratio in perinatal asphyxia and its correlation between APGAR score and urinary uric acid to creatinine ratio in perinatal asphyxia.Methods: A randomized case control hospital-based study was conducted on 50 asphyxiated and 50 normal newborn. Urinary uric acid and creatinine were estimated in spot urine within 24 hours after birth in both cases and controls. A ratio between the concentrations of uric acid to creatinine was estimated and comparison done between cases and controls.Results: Urinary uric acid to creatinine ratio can be used as an additional non-invasive, easy and early biochemical marker of birth asphyxia which biochemically supports the clinical diagnosis and the severity grading of asphyxia by APGAR score.Conclusions: Urinary uric acid to creatinine ratio can be used as an additional non-invasive, easy and early biochemical marker of birth asphyxia which biochemically supports the clinical diagnosis and the severity grading of asphyxia by APGAR score.

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supporting

confidence: 80%

Study of urinary uric acid to creatinine ratio as a biochemical marker of perinatal asphyxia and its correlation with Apgar Score

Sreekrishna

Eregowda

Sharma

2018

Int J Contemp Pediatr

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“…The results of the present study indicated that the mean UMDA:Cr ratio at birth, i.e., 2.62 ±0.29 μg/mg, was elevated significantly in newborns with perinatal asphyxia compared to that of the controls [1.63 ± 0.19 μg/mg]. These findings were in accordance with those of Banupriya et al (17), who found that the UMDA:Cr ratio in the study group was significantly higher than the UMDA:Cr ratio in the control group. Furthermore, the present study indicated that the mean UMDA:Cr ratio after 48 hr (3.70 ±0.52 μg/mg) was elevated significantly in newborns with perinatal asphyxia compared to that of the controls (1.96 ±0.15 μg/mg).…”

Section: Discussionsupporting

confidence: 93%

“…They also reported that the increase in UA levels indicated a purinic degradation during these first days of HIE. The results of the present study indicated that the mean UP:Cr ratio at birth was significantly elevated in newborns with perinatal asphyxia compared to the controls, and these findings were in accordance with those of Banupriya et al (17), who found that the UP:Cr ratio in the study group was significantly higher than it was in the control group. Also, the mean UP:Cr ratio after 48 hr was significantly elevated in newborns with perinatal asphyxia compared to the controls.…”

Section: Discussionsupporting

confidence: 93%

Serum and Urinary Malondialdehyde (MDA), Uric acid, and Protein as markers of perinatal asphyxia

Bana¹,

Maher²,

Gaber³

et al. 2016

Electron physician

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IntroductionPerinatal asphyxia (PA) is among the leading causes of neonatal morbidity and death in neonatal intensive care units (NICUs). The aims of this research were to determine the concentrations of malondialdehyde (MDA), urine MDA, uric acid, and protein in the cord blood of neonates with perinatal asphyxia and to determine their relationship with the severity of perinatal asphyxia.MethodsThis matched case-control study was conducted from October 2012 to March 2013. All of the cases and controls were selected from the Gynecology & Obstetrics Department and the NICUs, at Qous Central Hospital in Qena, Egypt. We allocated 20 full-term neonates who had perinatal asphyxia to the case group. Also, we selected 20 healthy neonates for the control group. The subjects were matched with respect to age and gender. At birth and 48 hours later, measurements were made of MDA in cord blood and urine, and uric acid, protein, and creatinine also were measured in both groups. The data were analyzed by SPSS, version 17, using the independent-samples t-test, ANOVA, Tukey’s test, and Spearman’s correlation coefficient.ResultsAt birth and 48 hr later, the newborns’ with PA had significantly higher levels of MDA in the cord blood, mean urinary uric acid/creatinine (UUA:Cr), protein/creatinine (UP:Cr), and MDA/creatinine ratio (UMDA:Cr) than the controls; their PA levels were correlated with the degree of hypoxic-ischemic encephalopathy (HIE). The babies who died due to PA had significantly higher levels of cord blood MDA, and they also had higher UUA:Cr, UP:Cr, and UMDA:Cr ratios than the babies who survived.ConclusionThe concentration of MDA in cord blood can be used as a diagnostic marker of oxidative stress in asphyxiated neonates. The ratios of the urinary excretion rates of uric acid, protein, and MDA to creatinine increased as the severity of perinatal asphyxia and associated brain damage increased.

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“…As the precursor of uric acid, abnormal level of xanthine in body has been found to be closely related to many diseases, including hyperuricemia, gout, xanthinuria, perinatal asphyxia and pre-eclampsia [2][3][4][5][6]. Meanwhile, xanthine is also an important biomarker in the food industries [7].…”

Section: Introductionmentioning

confidence: 99%

A colorimetric method for the determination of xanthine based on the aggregation of gold nanoparticles

Zhao

et al. 2014

Microchim Acta

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We describe a highly sensitive method for the determination of traces of xanthine based on the aggregation of citrate-stabilized gold nanoparticles (AuNPs). It is found that, under optimal conditions of pH, the imide group of xanthine is adsorbed on the surface of the AuNPs, thereby displacing citrate ions. This leads to an aggregation of the AuNPs via hydrogen-bond interactions. As a result, the color of the solution changes from red to blue which can be seen with bare eyes and also can be measured by spectrophotometry. The ratio of the absorbances at 630 nm and 520 nm is linearly related to the concentration of xanthine in the 125 nM to 6.0 μM range (r=0.9988), and the detection limit (3σ/slope) is 23 nM. The method is simple, feasible and fast.

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Can urinary excretion rate of malondialdehyde, uric acid and protein predict the severity and impending death in perinatal asphyxia?

Cited by 29 publications

References 30 publications

Study of urinary uric acid to creatinine ratio as a biochemical marker of perinatal asphyxia and its correlation with Apgar Score

Study of urinary uric acid to creatinine ratio as a biochemical marker of perinatal asphyxia and its correlation with Apgar Score

Serum and Urinary Malondialdehyde (MDA), Uric acid, and Protein as markers of perinatal asphyxia

A colorimetric method for the determination of xanthine based on the aggregation of gold nanoparticles

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