Can unipolar and bipolar pediatric major depression be differentiated from each other? A systematic review of cross-sectional studies examining differences in unipolar and bipolar depression

Uchida, Mai; Serra, Giulia; Zayas, Lázaro V.; Kenworthy, Tara; Faraone, Stephen V.; Biederman, Joseph

doi:10.1016/j.jad.2015.01.037

Cited by 35 publications

(27 citation statements)

References 28 publications

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“…Looking at sleep disturbances, the finding of middle insomnia and decreased need for sleep are in line with ample evidence that sleep disturbances are associated with BD, also prior to onset . The association of suicidal ideation and BD onset has been studied before, but findings are inconsistent . In adolescents with BD, prevalence of suicidal ideation has been estimated at 58% and suicide attempts at 20%–25%.…”

Section: Discussionmentioning

confidence: 63%

Baseline dimensional psychopathology and future mood disorder onset: findings from the Dutch Bipolar Offspring Study

Mesman

Nolen

Keijsers

et al. 2017

Acta Psychiatr Scand

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Section: Discussionmentioning

confidence: 63%

Baseline dimensional psychopathology and future mood disorder onset: findings from the Dutch Bipolar Offspring Study

Mesman

Nolen

Keijsers

et al. 2017

Acta Psychiatr Scand

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“…A significant minority of children or youth with MDD will eventually go on to develop BD, with an average rate of 28% being reported 572, 573. Risk factors for switch to mania following a depressive episode include a family history of mood disorders, emotional and behavioural dysregulation, subthreshold manic symptoms, cyclothymia, atypical depression and psychosis 572.…”

Section: Specific Populationsmentioning

confidence: 99%

“…Risk factors for switch to mania following a depressive episode include a family history of mood disorders, emotional and behavioural dysregulation, subthreshold manic symptoms, cyclothymia, atypical depression and psychosis 572. A recent meta‐analysis suggested that the most potent predictors were family history, an earlier age of onset and the presence of psychotic symptoms 574.…”

Section: Specific Populationsmentioning

confidence: 99%

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

et al. 2018

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The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published treatment guidelines for bipolar disorder in 2005, along with international commentaries and subsequent updates in 2007, 2009, and 2013. The last two updates were published in collaboration with the International Society for Bipolar Disorders (ISBD). These 2018 CANMAT and ISBD Bipolar Treatment Guidelines represent the significant advances in the field since the last full edition was published in 2005, including updates to diagnosis and management as well as new research into pharmacological and psychological treatments. These advances have been translated into clear and easy to use recommendations for first, second, and third‐ line treatments, with consideration given to levels of evidence for efficacy, clinical support based on experience, and consensus ratings of safety, tolerability, and treatment‐emergent switch risk. New to these guidelines, hierarchical rankings were created for first and second‐ line treatments recommended for acute mania, acute depression, and maintenance treatment in bipolar I disorder. Created by considering the impact of each treatment across all phases of illness, this hierarchy will further assist clinicians in making evidence‐based treatment decisions. Lithium, quetiapine, divalproex, asenapine, aripiprazole, paliperidone, risperidone, and cariprazine alone or in combination are recommended as first‐line treatments for acute mania. First‐line options for bipolar I depression include quetiapine, lurasidone plus lithium or divalproex, lithium, lamotrigine, lurasidone, or adjunctive lamotrigine. While medications that have been shown to be effective for the acute phase should generally be continued for the maintenance phase in bipolar I disorder, there are some exceptions (such as with antidepressants); and available data suggest that lithium, quetiapine, divalproex, lamotrigine, asenapine, and aripiprazole monotherapy or combination treatments should be considered first‐line for those initiating or switching treatment during the maintenance phase. In addition to addressing issues in bipolar I disorder, these guidelines also provide an overview of, and recommendations for, clinical management of bipolar II disorder, as well as advice on specific populations, such as women at various stages of the reproductive cycle, children and adolescents, and older adults. There are also discussions on the impact of specific psychiatric and medical comorbidities such as substance use, anxiety, and metabolic disorders. Finally, an overview of issues related to safety and monitoring is provided. The CANMAT and ISBD groups hope that these guidelines become a valuable tool for practitioners across the globe.

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“…Second, the introduction of the concept of MDD with DSM-III in 1980 involved lumping a broad range of depressive conditions into a single group after excluding mania or hypomania. Distinctions between depressive phases of BD and MDD were not addressed initially, but their symptomatic, longitudinal, epidemiological, and therapeutic differences are increasingly recognized [2,8,9,10,11,12]. Third, blurring the distinction between unipolar and bipolar depression is encouraged by renewed consideration of elements of hypomania in many depressive illnesses [13,14,15], as noted a century ago [2,3].…”

Section: Conceptualizations About Mood Disordersmentioning

confidence: 99%

Morbidity in Depressive Disorders

Baldessarini

Forte

Selle

et al. 2017

Psychother Psychosom

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Can unipolar and bipolar pediatric major depression be differentiated from each other? A systematic review of cross-sectional studies examining differences in unipolar and bipolar depression

Cited by 35 publications

References 28 publications

Baseline dimensional psychopathology and future mood disorder onset: findings from the Dutch Bipolar Offspring Study

Baseline dimensional psychopathology and future mood disorder onset: findings from the Dutch Bipolar Offspring Study

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

Morbidity in Depressive Disorders

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