Can Tumor-Infiltrating Lymphocytes (TILs) Be a Predictive Factor for Lymph Nodes Status in Both Early Stage and Locally Advanced Breast Cancer?

Caziuc, Alexandra; Schlanger, Diana; Amarinei, Giorgiana; Dindelegan, George

doi:10.3390/jcm8040545

Cited by 20 publications

(18 citation statements)

References 48 publications

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“…Our hypothesis was that the TIL density may be a predictor of SLNM. The correlation between TILs and lymph node metastasis has been reported in gastric cancer, melanoma, and breast cancer [31][32][33]. A study on breast cancer examined 76 patients who underwent surgery first and 96 patients who underwent preoperative chemotherapy, and it reported that there was a correlation between TILs and lymph node metastasis in both groups.…”

Section: Discussionmentioning

confidence: 94%

Prediction of lymph node metastasis by tumor-infiltrating lymphocytes in T1 breast cancer

et al. 2020

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Background: Lymph node metastasis is more likely in early-stage breast cancer with lower tumor-infiltrating lymphocyte (TIL) density. Therefore, we investigated the correlation between TILs and lymph node metastasis in cT1 breast cancer patients undergoing surgery and the usefulness of TILs in predicting sentinel lymph node metastasis (SLNM) in cT1N0M0 breast cancer. Methods: We investigated 332 breast cancer patients who underwent surgery as the first-line treatment after preoperative diagnosis of cT1. A positive diagnosis of SLNM as an indication for axillary clearance was defined as macrometastasis in the sentinel lymph node (SLN) (macrometastasis: tumor diameter > 2 mm). Semi-quantitative evaluation of lymphocytes infiltrating the peritumoral stroma as TILs in primary tumor biopsy specimens prior to treatment was conducted. Results: For SLN biopsy (SLNB), a median of 2 (range, 1-8) SLNs were pathologically evaluated. Sixty cases (19.4%) of SLNM (macrometastasis: 46, micrometastasis: 16) were observed. Metastasis was significantly greater in breast cancers with tumor diameter > 10 mm than in those with diameter ≤ 10 mm (p = 0.016). Metastasis was significantly associated with lymphatic invasion (p < 0.001). These two clinicopathological factors correlated with SLNM even in patients diagnosed with cN0 (tumor size; p = 0.017, lymphatic invasion; p = 0.002). Multivariate analysis for SLNM predictors revealed lymphatic invasion (p = 0.008, odds ratio [OR] = 2.522) and TILs (p < 0.001, OR = 0.137) as independent factors. Conclusions: Our results suggest a correlation between lymph node metastasis and tumor immune-microenvironment in cT1 breast cancer. TIL density may be a predictor of SLNM in breast cancer without lymph node metastasis on preoperative imaging.

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Section: Discussionmentioning

confidence: 94%

Prediction of lymph node metastasis by tumor-infiltrating lymphocytes in T1 breast cancer

et al. 2020

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“…Our hypothesis was that the TIL density may be a predictor of SLNM. The correlation between TILs and lymph node metastasis has been reported in gastric cancer, melanoma, and breast cancer [31][32][33]. A study on breast cancer examined 76 patients who underwent surgery rst and 96 patients who underwent preoperative chemotherapy, and it reported that there was a correlation between TILs and lymph node metastasis in both groups.…”

Section: Discussionmentioning

confidence: 93%

Prediction of lymph node metastasis by tumor-infiltrating lymphocytes in T1 breast cancer

Takada

Kashiwagi

Asano

et al. 2020

Preprint

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Background: Lymph node metastasis is more likely in early-stage breast cancer with lower tumor-infiltrating lymphocyte (TIL) density. Therefore, we investigated the correlation between TILs and lymph node metastasis in cT1 breast cancer patients undergoing surgery and the usefulness of TILs in predicting sentinel lymph node metastasis (SLNM) in cT1N0M0 breast cancer.Methods: We investigated 332 breast cancer patients who underwent surgery as the first-line treatment after preoperative diagnosis of cT1. A positive diagnosis of SLNM as an indication for axillary clearance was defined as macrometastasis in the sentinel lymph node (SLN) (macrometastasis: tumor diameter >2 mm). Semi-quantitative evaluation of lymphocytes infiltrating the peritumoral stroma as TILs in primary tumor biopsy specimens prior to treatment was conducted.Results: For SLN biopsy (SLNB), a median of 2 (range, 1-8) SLNs were pathologically evaluated. Sixty cases (19.4%) of SLNM (macrometastasis: 46, micrometastasis: 16) were observed. Metastasis was significantly greater in breast cancers with tumor diameter >10 mm than in those with diameter 10 mm (p = 0.016). Metastasis was significantly associated with lymphatic invasion (p <0.001). These two clinicopathological factors correlated with SLNM even in patients diagnosed with cN0 (tumor size; p=0.017, lymphatic invasion; p=0.002). Multivariate analysis for SLNM predictors revealed lymphatic invasion (p=0.008, odds ratio [OR]=2.522) and TILs (p<0.001, OR=0.137) as independent factors.Conclusions: Our results suggest a correlation between lymph node metastasis and tumor immune-microenvironment in cT1 breast cancer. TIL density may be a predictor of SLNM in breast cancer without lymph node metastasis on preoperative imaging.

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“…Our hypothesis was that the TIL density may be a predictor of SLNM. The correlation between TILs and lymph node metastasis has been reported in gastric cancer, melanoma, and breast cancer [28][29][30]. A study on breast cancer examined 76 patients who underwent surgery first and 96 patients who underwent preoperative chemotherapy, and it reported that there was a correlation between TILs and lymph node metastasis in both groups.…”

Section: Discussionmentioning

confidence: 94%

Prediction of Lymph Node Metastasis by Tumor-Infiltrating Lymphocytes in T1 Breast Cancer

Takada

Kashiwagi

Asano

et al. 2020

Preprint

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Purpose:Lymph node metastasis is more likely in early-stage breast cancer with lower tumor-infiltrating lymphocyte (TIL) density. Therefore, we investigated the correlation between TILs and lymph node metastasis in cT1 breast cancer patients undergoing surgery and the usefulness of TILs in predicting sentinel lymph node metastasis (SLNM) in cT1N0M0 breast cancer.Methods:We investigated 332 breast cancer patients who underwent surgery as the first-line treatment after preoperative diagnosis of cT1. A positive diagnosis of SLNM as an indication for axillary clearance was defined as macrometastasis in the sentinel lymph node (SLN) (macrometastasis: tumor diameter > 2 mm). Semi-quantitative evaluation of lymphocytes infiltrating the peritumoral stroma as TILs in primary tumor biopsy specimens prior to treatment was conducted.Results:For SLN biopsy (SLNB), a median of 2 (range, 1–8) SLNs were pathologically evaluated. Sixty cases (19.4%) of SLNM (macrometastasis: 46, micrometastasis: 16) were observed. Metastasis was significantly greater in breast cancers with tumor diameter > 10 mm than in those with diameter \le 10 mm (p = 0.016). Metastasis was significantly associated with lymphatic invasion (p <0.001). These two clinicopathological factors correlated with SLNM even in patients diagnosed with cN0 (tumor size; p = 0.017, lymphatic invasion; p = 0.002). Multivariate analysis for SLNM predictors revealed lymphatic invasion (p = 0.008, odds ratio [OR]=2.522) and TILs (p < 0.001, OR = 0.137) as independent factors.Conclusions:Our results suggest a correlation between lymph node metastasis and tumor immune-microenvironment in cT1 breast cancer. TIL density may be a predictor of SLNM in breast cancer without lymph node metastasis on preoperative imaging.

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Can Tumor-Infiltrating Lymphocytes (TILs) Be a Predictive Factor for Lymph Nodes Status in Both Early Stage and Locally Advanced Breast Cancer?

Cited by 20 publications

References 48 publications

Prediction of lymph node metastasis by tumor-infiltrating lymphocytes in T1 breast cancer

Prediction of lymph node metastasis by tumor-infiltrating lymphocytes in T1 breast cancer

Prediction of lymph node metastasis by tumor-infiltrating lymphocytes in T1 breast cancer

Prediction of Lymph Node Metastasis by Tumor-Infiltrating Lymphocytes in T1 Breast Cancer

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