Can training induce inflammatory control in asthma, or is it symptom control only?

Pitzner-Fabricius, Anders; Toennesen, Louise Lindhardt; Backer, Vibeke

doi:10.1097/mcp.0000000000000648

Cited by 7 publications

(11 citation statements)

References 38 publications

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“…Intensity of physical activity undertaken by asthma patients has been shown to be positively correlated with peak expiratory flow [22]. Although causation could not be determined in this cross-sectional study, it raises the question as to whether those with less severe disease are able to undertake more activity or whether those who undertake more activity are able to modulate their disease burden, as supported by findings in a recent review [23]. Obesity and musculoskeletal problems are conditions that are common in asthma and exacerbated by oral steroid therapy.…”

Section: Introductionmentioning

confidence: 70%

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Patient perceived barriers to exercise and their clinical associations in difficult asthma

Freeman

Hill

Newell

et al. 2020

asthma res and pract

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Background: Exercise is recommended in guidelines for asthma management and has beneficial effects on symptom control, inflammation and lung function in patients with sub-optimally controlled asthma. Despite this, physical activity levels in patients with difficult asthma are often impaired. Understanding the barriers to exercise in people with difficult asthma is crucial for increasing their activity, and in implementing successful, disease modifying, and holistic approaches to improve their health. Methods: 62 Patients within the WATCH Difficult Asthma Cohort (Southampton, UK) completed an Exercise Therapy Burden Questionnaire (ETBQ). The results were analyzed with contemporaneous asthma-related data to determine relationships between perceived exercise barriers and asthma and comorbidity characteristics Results: Patients were reflective of a difficult asthma cohort, 66% were female, and 63% were atopic. They had a high BMI (median [inter-quartile range]) of 29.3 [25.5-36.2], age of 53.5 [38.75, 65.25], impaired spirometry with FEV1 73% predicted [59.5, 86.6%] and FEV/FVC ratio of 72 [56.5, 78.0] and poor symptom control, as defined by an Asthma Control Questionnaire (ACQ6) result of 2.4 [1.28, 3.2]. A high perceived barriers to exercise score was significantly correlated with increased asthma symptoms (r = 0.452, p < 0.0001), anxiety (r = 0.375, p = 0.005) and depression (r = 0.363, p = 0.008), poor quality of life (r = 0.345, p = 0.015) and number of rescue oral steroid courses in the past 12 months (r = 0.257, p = 0.048). Lung function, blood eosinophil count, FeNO, Njimegen and SNOT22 scores, BMI and hospitalisations in the previous year were not related to exercise perceptions. Conclusion: In difficult asthma, perceived barriers to exercise are related to symptom burden and psychological morbidity. Therefore, exercise interventions combined with psychological input such as CBT to restructure thought processes around these perceived barriers may be useful in facilitating adoption of exercise.

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Section: Introductionmentioning

confidence: 70%

“…Therefore, our results which show that a higher barrier to exercise correlates with a lower QoL score are not unexpected. Exercise is, however, known to improve health related QoL in asthma [4,23] and therefore interventions to address this paradox need investigating.…”

Section: Perceived Symptom Burden Impacts Perceived Barriers To Exercisementioning

confidence: 99%

Patient perceived barriers to exercise and their clinical associations in difficult asthma

Freeman

Hill

Newell

et al. 2020

asthma res and pract

View full text Add to dashboard Cite

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“…In part, improvement in QOL may be due to an increase in asthma free days (the days being free of asthma symptoms)8 or related to a reduction of the feeling of dyspnoea 5 8. Recently, evidence has emerged proposing that improved inflammatory control through a reduction in systemic low-grade inflammation, particularly in association with weight loss in this cohort may be in-part contributing to the improvement in asthma symptoms with physical activity 9…”

Section: Physical Activity and Asthmamentioning

confidence: 94%

Moving more: physical activity and its positive effects on long term conditions in children and young people

2020

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While the benefits of regular participation in physical activity in children and young people are clear, misconceptions have developed about the possible negative effects and potential complications of exercise on long-term conditions such as epilepsy, asthma and diabetes. Over the last decade evidence has emerged supporting the positive impact that physical activity has on long-term conditions. Previous concerns were raised about the risks of hypoglycaemia in children with type 1 diabetes mellitus (T1DM) thus limiting participation in sports. Importantly, physical activity improves the metabolic profile, bone mineral density, cardiorespiratory fitness and insulin sensitivity while lowering mortality risk in children with T1DM. Children with asthma were prevented from doing exercise due to concerns about precipitating an acute asthmatic episode. To the contrary, physical activity interventions have consistently shown an increase in cardiovascular fitness, physical capacity, asthma-free days and quality of life in childhood asthmatics. Children with epilepsy are often excluded from sports due to concerns relating to increased seizure frequency, yet evidence suggests that this is not the case. The evidence supporting physical activity in childhood survivors of cancer is growing but still primarily confined to patients with acute lymphoblastic leukaemia. Participation in sports and physical activity also reduces mental health problems developing in adolescence. While further research is required to investigate benefits of physical activity on specific aspects of long-term conditions in children, in general this group should be advised to increase participation in sports and exercise as a means of improving long-term physical and mental health.

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“…Many studies show that walking, dancing, jogging, cycling, as well as static and dynamic gymnastics improve the course of the disease, improve the rates of external respiration, anxiety and depression at any stage of the disease [79, 80, 81 , 82, 83]. The following sports have a particularly positive effect on asthma control: football, basketball, swimming [84], and in patients with "night" asthma aerobic exercise reduces the frequency of nocturnal symptoms in both adults and children [85], increases aerobic endurance [ 86], but do not affect the activity of airway inflammation [87,88]. However, a year later there was no significant difference in VO2 and ACQ (asthma control questionnaire) [89].…”

Section: Elimination Of Allergensmentioning

confidence: 99%

“…Russell M. et.al. [91] believe that less intense exercise gives a more positive result in bronchial asthma, while others -medium and high-intensity exercise give a worse result [88]. A long-term (12 years) study proved that the duration of daily physical activity (> 240 min) визиває щорічно менше зниження FEV 1 та FVC, чим у пацієнтів, фізична активність яких була < 240 minutes per day [92].…”

Section: Elimination Of Allergensunclassified

Non-drug treatments and rehabilitation of patients with bronchial asthma

Mytskan

Ostapiak

Mytskan

2020

HSR

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The aim is to analyze the effectiveness of non-drug methods of treatment and rehabilitation of children and adults with bronchial asthma.Methods. To realize the purpose of the study, a system-functional analysis of special literature and materials of the Internet was used.Results. The standard approach to antiasthmatic therapy does not always lead to a controlled course. Reducing the impact of allergens both in the home and in the workplace is an effective measure to control the disease. Phytotherapy and reflexology are widely and effectively used. Diet therapy is ineffective, the use of vitamin D in the treatment and rehabilitation of patients with bronchial asthma is encouraging. The vaccine does not increase the risk of the disease, but it is not effective for prevention. Increasing physical activity is the most effective method of rehabilitating patients. Evidence from recent studies suggests that interventions aimed at eliminating a single allergen may be effective in reducing allergen levels and asthma incidence, and this approach deserves further study. Currently, a comprehensive multifaceted study of acupuncture, which will be able to provide reliable clinical evidence of the effectiveness of acupuncture for the treatment and prevention of asthma. At the same time, there is a need for comprehensive research in the field of phytotherapy and training of respiratory muscles.Conclusion. Non-drug methods of prevention and rehabilitation are widely used (as additional) in bronchial asthma. Despite many years of use of phytotherapy, acupuncture, breathing exercises in the treatment and rehabilitation of asthma, so far there are no clear recommendations for their use: indications, dosage, duration, frequency and the lack of standardization makes it difficult to use them.

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Can training induce inflammatory control in asthma, or is it symptom control only?

Cited by 7 publications

References 38 publications

Patient perceived barriers to exercise and their clinical associations in difficult asthma

Patient perceived barriers to exercise and their clinical associations in difficult asthma

Moving more: physical activity and its positive effects on long term conditions in children and young people

Non-drug treatments and rehabilitation of patients with bronchial asthma

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