Can Topiramate Induce Pruritus? A Case Report and Review of Literature

Signorelli, Maria; Cinconze, M.; Nasca, Maria Rita; Marino, Mónica; Martinotti, Giovanni; Giannantonio, Massimo Di; Aguglia, Eugenio

doi:10.2174/1871527314666150225123827

Cited by 7 publications

(4 citation statements)

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“…7 However, medications that may benefit psychogenic pruritus can also cause drug-induced pruritus (see section 7.11), for example topiramate. 189,190 Input from clinical psychology and/or psychiatry should always be considered. The potential role of new psychological approaches that have proved effective in chronic pain is also promising in the management of chronic pruritus and merits further research including acceptance and commitment therapy and mindfulness-based stress reduction.…”

Section: Psychological and Emotional Factors In Pruritusmentioning

confidence: 99%

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

Millington¹,

Collins²,

Lovell³

et al. 2018

Br J Dermatol

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SummaryPruritus (or itch) is a common and distressing symptom of many skin diseases, systemic illnesses and psychological disorders. Itch is perhaps the commonest presenting symptom of skin disorders. In any two week period, 8 to 9% of the population suffer from significant pruritus. The focus of this guideline is not itchy rashes, but rather the situation where itch is present without rash. The guidelines also do not cover itch in children, in pregnancy, nor do they detail the science of the cause of itch. The study group consist mostly of dermatologists (skin specialists) from a number of hospitals in the U.K., but a number of other hospital doctors, a nurse and a general practitioner (GP) are also part of the team. There may be an underlying cause of pruritus, such as blood disorders, iron deficiency or excess, kidney problems, liver problems, cancer, infections, medications, behavioural factors, dry skin or any combination of these with old age. This can be significant in 20 to 30% of cases of itchy skin without rash. There remain a small number of individuals with itch and no apparent underlying cause or rash. It is always important to look for an underlying causative condition, as the most effective management of pruritus without rash depends on the treatment of any underlying disease. The management of itch appears to be very situation specific, even if the underlying cause cannot be treated. The management of true pruritus of unknown cause is different again.

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Section: Psychological and Emotional Factors In Pruritusmentioning

confidence: 99%

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

Millington¹,

Collins²,

Lovell³

et al. 2018

Br J Dermatol

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“…It should not be forgotten that drugs may sometimes be more frequently associated with pruritus than the systemic diseases for which they are used. For example, topiramate may improve psychogenic pruritus, which also induced drug-induced pruritus (15).…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting the Etiology of Intractable Pruritus in Hospitalized Patients Without Primary Skin Lesions

Akdoğan¹,

Uysal²,

Öktem³

et al. 2019

Istanbul Med J

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Amaç: Kaşıntı sık görülen bir belirti olup dermatolojik, sistemik, nörolojik, psikojenik, mikst ve bilinmeyen sebepleri vardır. Bu çalışmanın amacı sekonder deri lezyonları (SDL) ile prezente olan, dirençli kaşıntı nedeniyle hastanede yatan hastalarda kaşıntı etiyolojisini (KET) bulmak ve KET'i etkileyen faktörleri değerlendirmektedir. Yöntemler: Retrospektif olarak SDL olan 95 hasta (erkek/ kadın: 47/48) çalışmaya alındı. Demografik ve klinik özellikler, tanısal işlemler ve tedavi ajanları kaydedildi. KET dermatolojik ve dermatoloji dışı sebepler olarak tanımlandı. Bulgular: Çalışmamızda ortalama (aralık) yaş 61 (11-91) yıl ve hastalık süresi 2 (0,06-120) aydı. Kaşıntı %78 hastada dermatolojik, %22 hastada dermatoloji dışı sebeplerle ilişkili bulundu. Tek değişkenli analiz yaş, ortalama hastalık süresi, akut veya kronik seyir, 3 aydan uzun süre sürekli ilaç kullanımı, kaşıntıya yol açabilecek ilaç kullanımı, eşlik eden sistemik hastalık, polifarmasi, böbrek fonksiyon testleri ve uyku bozukluğu varlığı ile altta yatan dermatolojik sebebe bağlı kaşıntısı (DSK) olan ve olmayan hastalarda ilişki gösterdi (sırasıyla p=0,

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“…При психогенному свербежі часто застосовуються нейроактивні препарати, включаючи габапентин, антидепресанти, нейролептики в низькій дозі та міртазапін [7]. Однак медикаменти, які можуть спричинити психогенний свербіж, також можуть спричинити свербіж, викликаний наркотичними препаратами, наприклад, топірамат [108,109].…”

Section: психологічні та емоційні фактори свербежуunclassified

Itching as the onset of pain (part 2)

Kushnir

Dmytrenko

Katilov

et al. 2020

PMJUA

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Itching of the skin is a particularly unpleasant subjective sensation that causes the need to scratch. Physiological itching occurs in response to environmental irritants (friction, insect crawling, temperature changes, etc.) and disappears after elimination of the cause. Pathological itching is caused by changes in the skin or throughout the body and causes a strong need to get rid of itching by combing or any other method. Itching is a common symptom of local (dermatological) or general (systemic) disease. It can be limited (localized) or diffuse (generalized).One of the causes of itching is often noted endocrine diseases and metabolic disorders: hyper- and hypofunction of the thyroid gland, diabetes mellitus and hyperparathyroidism. In thyroid hyperfunction, generalized (inconstant and little-pronounced) itching of the skin is observed in the clinical picture only in 10 % of patients. It is accepted that itching of the skin in thyrotoxicosis syndrome is due to increased activity of kinin in combination with an increase in major metabolism and an increase in body and skin temperature (123).Itching caused by impaired bile secretion is characteristic of many diseases of the liver: primary biliary cirrhosis, sclerosing cholangitis, viral hepatitis caused by cholestasis medications and other causes of obstructive jaundice. It is in these cases that prurigo is usually generalized, but in some typical cases it is more pronounced on the feet and palms. With this pathology, itching is caused by obstruction of the biliary tract, however, and to this day, no close correlation has been found between serum bilirubin and the severity of itching.If it was previously thought that itching in pathology of the peripheral or central nervous system, such as multiple sclerosis, neuropathy, compression or irritation of nerves (e.g., paraesthetic dorsalgia, brachioradial itching) is also a significant symptom, then modern studies prove that in more cases, itching is not characteristic of most pathologies of the nervous system, so after a detailed anamnesis, examination and initial research, the patient should be referred to a related specialist, except in cases of about obvious postherpetic neuropathy, painless paresthesia, or brachioradial itching, which can often be guided in the provision of primary care.Instead, there are some psychological conditions and a number of psychiatric illnesses (obsessive-compulsive disorders, depression, and parasite illusions) that are most commonly diagnosed with the exclusion method. Neurotic squabbles are scattered on the body of the excorii, covered with scales that may occur in any area of the body that the patient may reach, but are often limited by limbs.

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Can Topiramate Induce Pruritus? A Case Report and Review of Literature

Cited by 7 publications

References 0 publications

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018

Factors Affecting the Etiology of Intractable Pruritus in Hospitalized Patients Without Primary Skin Lesions

Itching as the onset of pain (part 2)

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